The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.
Open accessAbstract
We have generated an mAb, RR3-15, that recognizes murine TCRs containing the V beta 11 domain. Using this antibody to stain peripheral T cells, we have demonstrated that V beta 11-bearing T cells are largely absent from strains of mice that express the class II MHC molecule, I-E. Studies with F1 mice demonstrate that this effect is dominant, consistent with tolerance. The clonal deletion of V beta 11-bearing T cells appears to occur intrathymically, as immature but not mature V beta 11+ T cells are present in the thymus of I-E-bearing mice. Examination of B6 x DBA/2 recombinant inbred strains demonstrates that the expression of I-E molecules is necessary for the clonal deletion of V beta 11-bearing T cells, but that other non-MHC genes control the clonal deletion process, as well. Paradoxically, only a small fraction of V beta 11+ T cell hybridomas are I-E reactive.
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Cites
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Cited by
An endogenous retrovirus mediating deletion of αβ T cells?
Woodland, D. L., Happ, M. P., Gollob, K. J., & Palmer, E. (1991) · Nature · doi:10.1038/349529a0 · Cited by 269
Self-citationBill, J., & Palmer, E. (1989) · Nature · doi:10.1038/341649a0 · Cited by 130
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Metadata
- Authors
- Bill, J., Kanagawa, O., Woodland, D. L., & Palmer, E.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-04-01
- Volume
- 169
- Issue
- 4
- Pages
- 1405-1419
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2070442757
- Cited by
- 323
- References
- 28
- FWCI
- 23.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bill, J., Kanagawa, O., Woodland, D. L., & Palmer, E. (1989). The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.169.4.1405
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
