The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The T Cell Receptor
Abstract
The primary structure of T cell receptor proteins and genes is well understood. Immunologists are now trying to understand the properties of these interesting molecules. Evidence suggests that T cell αβ receptors recognize a complex of an antigen-derived peptide bound to one of the cell-surface products of the major histocompatibility complex (MHC) genes. It is likely that αβ receptors and MHC proteins have coevolved to have some affinity for each other. During T cell development in the thymus, cells bearing self-reactive receptors are deleted by the mechanisms of tolerance, and cells are preferentially allowed to mature if they bear receptors that will be able to recognize antigen plus self-MHC after they have become full-fledged T cells. Some explanations for these phenomena have been tested, but no satisfactory theory can yet be proposed to account for them.
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Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
Heilig, J. S., & Tonegawa, S. (1986) · Nature · doi:10.1038/322836a0 · Cited by 448
T cell antigen receptors and the immunoglobulin supergene family
Hood, L. (1985) · Cell · doi:10.1016/0092-8674(85)90133-3 · Cited by 433
Cited by
T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
Evidence for a differential avidity model of T cell selection in the thymus
Ashton-Rickardt, P. G., Bandeira, A., Delaney, J. R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R. M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90505-3 · Cited by 668
Development and Selection of T Cells: Facts and Puzzles
Kisielow, P., & Von Boehmer, H. (1995) · Advances in Immunology · doi:10.1016/s0065-2776(08)60620-3 · Cited by 444
Bill, J., Kanagawa, O., Woodland, D. L., & Palmer, E. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.4.1405 · Cited by 323
Gargiulo, L., Lastraioli, S., Cerruti, G., Serra, M., Loiacono, F., Zupo, S., Luzzatto, L., & Notaro, R. (2007) · Blood · doi:10.1182/blood-2006-10-052381 · Cited by 56
Metadata
- Authors
- Marrack, P., & Kappler, J.
- Venue
- Science
- Published
- 1987-11-20
- Volume
- 238
- Issue
- 4830
- Pages
- 1073-1079
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098157239
- Cited by
- 551
- References
- 4
- FWCI
- 23.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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