The DOI matches its Crossref record.
Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line.
Open accessAbstract
A novel basic heparin-binding monocyte chemotactic factor (MCF) was purified to homogeneity from the conditioned media of human myelomonocytic cell line THP-1 based on its in vitro monocyte chemotactic activity. The purified MCF was homogenous and estimated to be 15 kD on SDS-PAGE. Purified MCF stimulated normal human monocytes to be growth inhibitory in vitro at 2-3 d for several human tumor cell lines. This represents the first report of the identification and purification of a chemoattractant cytokine that also activates monocytes but is distinct from interferons and other known cytokines.
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Metadata
- Authors
- Matsushima, K., Larsen, C. G., DuBois, G. C., & Oppenheim, J. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-04-01
- Volume
- 169
- Issue
- 4
- Pages
- 1485-1490
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2161784528
- Cited by
- 756
- References
- 0
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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