Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists
Open accessAbstract
Considerable success has been made with many peptide antigen formulations, and peptide-based vaccines are emerging as the next generation of prophylactic and remedial immunotherapy. However, finding an optimal platform balancing all of the requirements for an effective, specific and safe immune response remains a major challenge for many infectious and chronic diseases. This review outlines how peptide immunogenicity is influenced by the way in which peptides are presented to the immune system, underscoring the need for multifunctional delivery systems that couple antigen and adjuvant into a single construct. Particular attention is given to the ability of Toll-like receptor agonists to act as adjuvants. A survey of recent approaches to developing peptide antigen delivery systems is given, many of which incorporate Toll-like receptor agonists into the design.
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- Authors
- Black, M., Trent, A., Tirrell, M., & Olive, C.
- Affiliations
- University of California, Santa Barbara (US)
- QIMR Berghofer Medical Research Institute (AU)
- Venue
- Expert Review of Vaccines
- Publisher
- Informa UK Limited
- Published
- 2010-02
- Volume
- 9
- Issue
- 2
- Pages
- 157-173
- ISSN
- 1476-0584 (ISSN-L)
- 1744-8395
- PMC
- PMC2837080
- OpenAlex
- W2097727405
- Cited by
- 203
- References
- 8
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 12 · 2021: 20 · 2020: 15 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 10 · 2012: 10
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Expert Review of Vaccines (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL080718, NIH U01 HL080718)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- peptide vaccine, TLR agonists, vaccine adjuvants, antigen delivery systems, peptide immunogenicity, antigen presentation, immunotherapy
- MeSH terms
- Adjuvants, Immunologic, Humans, Vaccination, Vaccines, Subunit, Toll-Like Receptors
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