Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice
Open accessAbstract
We have studied contributions to hematopoiesis of genetically distinct stem cell populations in allophenic mice. Chimeras were made by aggregating embryos of inbred strains known to differ with respect to stem cell population kinetics. One partner strain (DBA/2) has previously been shown to normally have a stem cell (CFU-S) population of which 24% are in S-phase of the cell cycle, whereas the homologous population of the other partner strain (C57BL/6) was characterized by having only 2.6% in cycle (7). Contributions of the chimeric stem cell population to mature blood cell pools were studied throughout the life of the mice and intrinsic differences in stem cell function and aging were reflected in dynamic patterns of blood cell composition. The DBA/2 stem cell population was eclipsed by stem cells of the C57BL/6 genotype and, after 1.5-3 yr, the hemato-lymphoid composition of 22 of 27 mice studied for this long had shifted by at least 25 percentage points toward the C57BL/6 genotype. 8 of the 27 had hematolymphoid populations solely of C57BL/6 origin. To test whether or not a population of stem cells with an inherently higher cycling rate (DBA/2) might have a competitive advantage during repopulation, we engrafted allophenic marrow into lethally irradiated (C57BL/6 x DBA/2)F1 recipients. DBA/2 hematopoiesis was predominant early, far outstripping its representation in the marrow graft. Perhaps as a consequence of inherently greater DBA/2 stem cell proliferation, the populations of developmentally more restricted precursor populations (CFU-E, BFU-E, CFU-GM, CFU-GEMM) showed an overwhelming DBA/2 bias in the first 2-3 mo after engraftment. However, as in the allophenic mice themselves during the aging process, the C57BL/6 genotypic representation was ascendant over the subsequent months. The shift toward C57BL/6 genotype was first documented in the marrow and spleen precursor cell populations and was subsequently reflected in the circulating, mature blood cells. Bone marrow-derived stromal cell cultures from engrafted mice were studied and genotypic analyses showed donor representation in stromal cell populations that reflected donor hematopoietic contributions in the same recipient. Results from these studies involving two in vivo settings (allophenic mice and engraftment by allophenic marrow) are consistent with the notion that a cell autonomous difference in stem cell proliferation confers on one population a competitive repopulating advantage, but at the expense of longevity.
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Aged HSCs transplanted into young mice are functionally worse than young HSCs.
“That aged HSC are functionally impaired compared with their young counterparts upon transplantation in young mice”
From Aging of hematopoietic stem cells (2018) · cites this paper as [11]
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Cites
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Developmental potential and dynamic behavior of hematopoietic stem cells
Lemischka, I. R., Raulet, D. H., & Mulligan, R. C. (1986) · Cell · doi:10.1016/0092-8674(86)90566-0 · Cited by 880 · see citing works
Dick, J. E., Magli, M. C., Huszar, D., Phillips, R. A., & Bernstein, A. (1985) · Cell · doi:10.1016/s0092-8674(85)80102-1 · Cited by 637 · see citing works
Clonal and systemic analysis of long-term hematopoiesis in the mouse.Preprint
Jordan, C. T., & Lemischka, I. R. (1990) · Genes & Development · doi:10.1101/gad.4.2.220 · Cited by 566 · see citing works
Habu, S., Fukui, H., Shimamura, K., Kasai, M., Nagai, Y., Okumura, K., & Tamaoki, N. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.1.34 · Cited by 426 · see citing works
Wolf, N. S., & Trentin, J. J. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.127.1.205 · Cited by 332 · see citing works
Host origin of marrow stromal cells following allogeneic bone marrow transplantation
Simmons, P. J., Przepiorka, D., Thomas, E. D., & Torok‐Storb, B. (1987) · Nature · doi:10.1038/328429a0 · Cited by 302 · see citing works
Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man
Keating, A., Singer, J. W., Killen, P. D., Striker, G. E., Salo, A. C., Sanders, J. E., Thomas, E. D., Thorning, D., & Fialkow, P. J. (1982) · Nature · doi:10.1038/298280a0 · Cited by 247 · see citing works
Biology and Genetics of Hybrid Resistance
Bennett, M. C. (1987) · Advances in immunology · doi:10.1016/s0065-2776(08)60034-6 · Cited by 181 · see citing works
"Intrinsic" Immunological Tolerance in Allophenic Mice
Mintz, B., & Silvers, W. K. (1967) · Science · doi:10.1126/science.158.3807.1484 · Cited by 110 · see citing works
Capel, B., Hawley, R. G., Covarrubias, L., Hawley, T. S., & Mintz, B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4564 · Cited by 107 · see citing works
Suttles, J., Schwarting, G. A., & Stout, R. D. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.5.1586 · Cited by 100 · see citing works
Micklem, H. S., Lennon, J. E., Jd, A., & Gray, R. A. (1987) · PubMed · Cited by 94 · see citing works
Allophenic mice of multi-embryo origin.
Mintz, B., & Daniel, J. C. (1971) · Cited by 87 · see citing works
Mintz, B., & Palm, J. E. (1969) · The Journal of Experimental Medicine · doi:10.1084/jem.129.5.1013 · Cited by 81 · see citing works
Zant, G. E. V., Eldridge, P. W., Behringer, R. R., & Dewey, M. J. (1983) · Cell · doi:10.1016/0092-8674(83)90096-x · Cited by 75 · see citing works
Russell, E. S. (1966) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 67 · see citing works
Perkins, S., & Fleischman, R. A. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113419 · Cited by 66 · see citing works
Large numbers of primitive stem cells are active simultaneously in aggregated embryo chimeric mice
Harrison, D., Lerner, C. P., Hoppe, P., Carlson, G., & Alling, D. W. (1987) · Blood · doi:10.1182/blood.v69.3.773.773 · Cited by 57 · see citing works
Generation of purified stromal cell cultures that support lymphoid and myeloid precursors
Dorshkind, K. A., Johnson, A., Collins, L., Keller, G. M., & Phillips, R. A. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90029-3 · Cited by 52 · see citing works
Cellular site and mode of Fv-2 gene action
Behringer, R. R. (1985) · Cell · doi:10.1016/0092-8674(85)90158-8 · Cited by 32 · see citing works
Stable genotypic composition of blood cells in allophenic mice derived from congenic strains
Behringer, R. R., Eldridge, P. W., & Dewey, M. J. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90138-6 · Cited by 26 · see citing works
Chimeric Drift in Allophenic Mice
Warner, C. M., McIvor, J. L., & Stephens, T. (1977) · Differentiation · doi:10.1111/j.1432-0436.1977.tb01513.x · Cited by 17 · see citing works
Nakano, T., Waki, N., Asai, H., & Kitamura, Y. (1989) · Blood · doi:10.1182/blood.v73.2.425.425 · Cited by 17 · see citing works
Chimeric drift in allophenic mice
Stephens, T., McIvor, J. L., & Warner, C. M. (1977) · Cellular Immunology · doi:10.1016/0008-8749(77)90169-1 · Cited by 14 · see citing works
Schaefer, C. A., & Dewey, M. J. (1989) · Genetics · doi:10.1093/genetics/121.2.353 · Cited by 8 · see citing works
Carlson, G. A., Marshall, S. T., & Kiesche, A. (1986) · Transplantation · doi:10.1097/00007890-198606000-00004 · Cited by 5 · see citing works
Large numbers of primitive stem cells are active simultaneously in aggregated embryo chimeric mice
Harrison, D., Lerner, C. P., Hoppe, P., et al. (1987) · Blood · doi:10.1182/blood.v69.3.773.bloodjournal693773 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 29 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629 · see citing works
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
Goodell, M. A., Brose, K., Paradis, G. A., Conner, A. N., & Mulligan, R. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1797 · Cited by 2,902 · see citing works
“Serial transplantation of either whole bone marrow or highly purified HSC results in a loss of multilineage reconstituting capacity (3-8).”
BackgroundThe Biology of Hematopoietic Stem Cells
Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 774 · see citing works
Pereira, R. F., O’Hara, M. D., Laptev, A. V., Halford, K. W., Pollard, M. D., Class, R., Simón, D., Livezey, K., & Prockop, D. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1142 · Cited by 544 · see citing works
Aging of hematopoietic stem cells
de Haan, G., & Lazare, S. S. (2018) · Blood · doi:10.1182/blood-2017-06-746412 · Cited by 432 · see citing works
Identification and behavior of epithelial stem cells in the Drosophila ovary
Margolis, J. S., & Spradling, A. C. (1995) · Development · doi:10.1242/dev.121.11.3797 · Cited by 448 · see citing works
Bmi1, stem cells, and senescence regulation
Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495 · see citing works
Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
Liang, Y., Zant, G. E. V., & Szilvassy, S. J. (2005) · Blood · doi:10.1182/blood-2004-11-4282 · Cited by 384 · see citing works
Cho, R. H., Sieburg, H. B., & Muller-Sieburg, C. E. (2008) · Blood · doi:10.1182/blood-2007-11-123547 · Cited by 377 · see citing works
“That HSCs in D2 and B6 mice age differently had been established in an elegant series of experiments that followed D2 and B6 HSCs in aggregation chimeras.(58) In a subset of these chimeras, D2 HSCs stopped to contribute to peripheral hematopoiesis when mice aged.”
BackgroundT cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372 · see citing works
de Haan, G., NIJHOF, W., & Zant, G. E. V. (1997) · Blood · doi:10.1182/blood.v89.5.1543 · Cited by 300 · see citing works
The aging of lympho-hematopoietic stem cells
Geiger, H., & Van Zant, G. (2002) · Nature Immunology · doi:10.1038/ni0402-329 · Cited by 233 · see citing works
“The implications of strain-specific variation on the effects of age on HSC populations were demonstrated by experiments in which eight-cell embryos from C57BL/6 and DBA/2 mice were combined ex vivo to form chimeric embryos called allophenic”
MethodDynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging
de Haan, G., & Van Zant, G. (1999) · Blood · doi:10.1182/blood.v93.10.3294.410k07_3294_3301 · Cited by 208 · see citing works
The role of stem cells in aging
Zant, G. E. V., & Liang, Y. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00088-2 · Cited by 194 · see citing works
“There is growing evidence that many of the properties of the stem cell population are determined by cellintrinsic mechanisms [107,177–182].”
BackgroundIn Utero Hematopoietic Stem Cell Transplantation: Ontogenic Opportunities and Biologic Barriers
Flake, A. W., & Zanjani, E. D. (1999) · Blood · doi:10.1182/blood.v94.7.2179.419k43_2179_2191 · Cited by 189 · see citing works
CLARK, B. R., & Keating, A. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb31044.x · Cited by 176 · see citing works
Spangrude, G. J., & Brooks, D. (1993) · Blood · doi:10.1182/blood.v82.11.3327.3327 · Cited by 169 · see citing works
Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene
Haan, G. D., & Zant, G. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.529 · Cited by 134 · see citing works
Heterogeneity of hematopoietic stem cells
Uchida, N., Fleming, W., Alpern, E., & Weissman, I. L. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90002-a · Cited by 133 · see citing works
Genetic regulation of primitive hematopoietic stem cell senescence
Chen, J., Astle, C. M., & Harrison, D. E. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(99)00157-5 · Cited by 131 · see citing works
Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging
Kamminga, L. M., van Os, R., Ausema, A., Noach, E. J. K., Weersing, E., Dontje, B., Vellenga, E., & de Haan, G. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0066 · Cited by 128 · see citing works
Development and aging of primitive hematopoietic stem cells in BALB/cBy mice
Chen, J., Astle, C. M., & Harrison, D. E. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(99)00018-1 · Cited by 109 · see citing works
“In allophenic mice between B6 and D2 (DBA/2), D2 cells populate most of the hemopoietic system at young ages and are replaced by B6 cells at old ages, suggesting aging of D2 but not B6 HSC [14,15].”
BackgroundHematopoietic stem cell aging and self-renewal
Dykstra, B. J., & de Haan, G. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0529-9 · Cited by 106 · see citing works
A Genetic Determinant That Specifically Regulates the Frequency of Hematopoietic Stem Cells
Morrison, S. J., Qian, D., Jerabek, L., Thiel, B., Park, I.-K., Ford, P. S., Kiel, M. J., Schork, N. J., Weissman, I. L., & Clarke, M. F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.635 · Cited by 105 · see citing works
Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy
Geiger, H., True, J. M., de Haan, G., & Zant, G. E. V. (2001) · Blood · doi:10.1182/blood.v98.10.2966 · Cited by 103 · see citing works
Gerrits, A., Walasek, M. A., Olthof, S. G. M., Weersing, E., Ritsema, M., Zwart, E., van Os, R. P., Bystrykh, L. V., & de Haan, G. (2011) · Blood · doi:10.1182/blood-2011-01-331686 · Cited by 101 · see citing works
Stem cells, aging, and cancer: inevitabilities and outcomes
Bell, D. R., & Zant, G. E. V. (2004) · Oncogene · doi:10.1038/sj.onc.1207949 · Cited by 99 · see citing works
“Second, embryo-aggregated cellular chimeras (allophenic mice), composed of cells of two strains, showed wide variation in hematopoietic phenotypes, and shed light on several issues (Van Zant et al., 1990).”
BackgroundAging in the lympho-hematopoietic stem cell compartment
Geiger, H., & Rudolph, K. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.010 · Cited by 97 · see citing works
Liang, Y., Jansen, M., Aronow, B. J., Geiger, H., & Zant, G. E. V. (2007) · Nature Genetics · doi:10.1038/ng1938 · Cited by 97 · see citing works
“Longitudinal studies of hematopoiesis in embryo-aggregated chimeric mice compounded from these two strains have demonstrated that stem cell contributions are cell autonomous and strain specific, which suggests that polymorphic genes account for at least part of the interstrain stem cell variations, possibly including…”
An X chromosome gene regulates hematopoietic stem cell kinetics
Abkowitz, J. L., Taboada, M. R., Shelton, G. H., Catlin, S. N., Guttorp, P. M., & Kiklevich, J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3862 · Cited by 90 · see citing works
de Haan, G., & van Zant, G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.707 · Cited by 87 · see citing works
“the maximal life span of that strain (7).”
BackgroundAging-Associated Changes in Hematopoiesis and Leukemogenesis: What's the Connection?
Henry, C. J., Marusyk, A., & DeGregori, J. V. (2011) · Aging · doi:10.18632/aging.100351 · Cited by 83 · see citing works
Hematopoietic Stem Cells and the Aging Hematopoietic System
Gazit, R., Weissman, I. L., & Rossi, D. J. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2008.07.010 · Cited by 84 · see citing works
Bone Marrow-Derived Cells: The Influence of Aging and Cellular Senescence
Beausejour, C. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-68976-8_4 · Cited by 79 · see citing works
“C57BL/6 and DBA/2 embryos and observed that within the course of a lifetime, DBA/2 HSC function declined to the point where all blood formation was C57BL/6 derived ( Van Zant et al. 1990, 1992 ).”
BackgroundLanger, J., Henckaerts, E., Orenstein, J., & Snoeck, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030980 · Cited by 73 · see citing works
“Given the potential role of TGF- 2 in maintaining the function of HSCs that have undergone replicative stress, it will be of interest to determine whether TGF- 2 also plays a role in the significant genetic variation in the age-related decline in HSC function in inbred mice (3, 4, 11, 53), which has been shown to be c…”
BackgroundEffects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
Ertl, R. P., Chen, J., Astle, C. M., Duffy, T. M., & Harrison, D. E. (2007) · Blood · doi:10.1182/blood-2007-01-069807 · Cited by 71 · see citing works
Bone marrow stromal cells as a vehicle for gene transfer
Ding, L., Lu, S. Q., Batchu, R. B., Saylors, R. L., & Munshi, N. C. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300973 · Cited by 69 · see citing works
de Haan, G., Bystrykh, L. V., Weersing, E., Dontje, B., Geiger, H., Ivanova, N. B., Lemischka, I. R., Vellenga, E., & Zant, G. E. V. (2002) · Blood · doi:10.1182/blood-2002-03-0808 · Cited by 69 · see citing works
Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics.
Phillips, R. L., Reinhart, A. J., & Zant, G. E. V. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11607 · Cited by 68 · see citing works
Cellular Memory and Hematopoietic Stem Cell Aging
Kamminga, L. M., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0345 · Cited by 62 · see citing works
Does functional depletion of stem cells drive aging?
Schlessinger, D., & Zant, G. E. V. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00299-8 · Cited by 62 · see citing works
Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
Geiger, H., Rennebeck, G., & Zant, G. E. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408654102 · Cited by 61 · see citing works
Agematsu, K., & Nakahori, Y. (1991) · British Journal of Haematology · doi:10.1111/j.1365-2141.1991.tb08041.x · Cited by 61 · see citing works
Hematopoietic stem-cell differentiation
Spangrude, G. J. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90046-4 · Cited by 60 · see citing works
Hematopoietic reconstitution with androgenetic and gynogenetic stem cellsPreprint
Eckardt, S., Leu, N. A., Bradley, H. L., Kato, H., Bunting, K. D., & McLaughlin, K. J. (2007) · Genes & Development · doi:10.1101/gad.1524207 · Cited by 59 · see citing works
“Such strain-specific stem cell properties have been previously associated with observations in mouse chimeras between DBA/2 and B6 strains, in which hematopoiesis over time as well as long-term engraftment into secondary recipients was accomplished by B6-derived cells (Van Zant et al. 1990, 1992).”
BackgroundIn Utero Hematopoietic Stem Cell Transplantation: Progress toward Clinical Application
Merianos, D. J., Heaton, T. E., & Flake, A. W. (2008) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2008.02.012 · Cited by 54 · see citing works
“In this model when donor strains genetically differ with respect to HSC cycling, the more rapidly cycling population will emerge as the dominant hematopoietic contributor [61-63].”
BackgroundSenescence and functional failure in hematopoietic stem cells
Chen, J. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.08.001 · Cited by 53 · see citing works
“In the B6-D2 allophenic mice, D2 HSCs showed high functionality early in life and were then eclipsed by HSCs of the B6 genotype [29].”
BackgroundHenckaerts, E., Langer, J., & Snoeck, H. (2004) · Blood · doi:10.1182/blood-2003-12-4304 · Cited by 52 · see citing works
de Haan, G., Szilvassy, S. J., Meyerrose, T. E., Dontje, B., Grimes, B. A., & Zant, G. E. V. (2000) · Blood · doi:10.1182/blood.v96.4.1374 · Cited by 52 · see citing works
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
Watt, S. M., & Visser, J. W. M. (1992) · Cell Proliferation · doi:10.1111/j.1365-2184.1992.tb01440.x · Cited by 50 · see citing works
Aging stem cells, latexin, and longevity
Liang, Y., & Zant, G. E. V. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.032 · Cited by 42 · see citing works
Henckaerts, E., Geiger, H., Langer, J., Rebollo, P., Zant, G. E. V., & Snoeck, H. (2002) · Blood · doi:10.1182/blood.v99.11.3947 · Cited by 42 · see citing works
Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2
de Haan, G., & GERRITS, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.008 · Cited by 42 · see citing works
Bogue, M. A., Peters, L. L., Paigen, B. J., Korstanje, R., Yuan, R., Ackert‐Bicknell, C. L., Grubb, S. C., Churchill, G. A., & Chesler, E. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu223 · Cited by 38 · see citing works
Wolf, N. S., & Pendergrass, W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b502 · Cited by 37 · see citing works
Zant, G. E. V., Chen, J., & Scott-Micus, K. (1991) · Blood · doi:10.1182/blood.v77.4.756.756 · Cited by 34 · see citing works
“WBCs from each sample were subjected to three types of analysis: (1) GPI analysis to determine the fraction of each of the donor and host genotypes, (2) Southern blottingof Sac I cut DNA to determine the number of copies of Ne0 per cell in the population (copy number), and (3) Southern blottingof Dru I cut DNA to dete…”
BackgroundMethodCell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
Song, Z., Ju, Z., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.009 · Cited by 33 · see citing works
Tanaka, J., Kasai, M., Imamura, M., Masauzi, N., Ohizumi, H., Matsuura, A., Morii, K., Kiyama, Y., Naohara, T., Saitoh, M., et al. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04764.x · Cited by 29 · see citing works
Henckaerts, E., Langer, J., Orenstein, J., & Snoeck, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2486 · Cited by 28 · see citing works
“These fi ndings were consistent with the observation that in embryo-aggregated D2-B6 mice, DBA/2-derived hemopoiesis is eclipsed upon aging by C57BL/6-derived hemopoiesis through stem cell-intrinsic mechanisms (3, 4 , 51).”
ResultGenetic Control of Stem Cells: Implications for Aging
Zant, G. E. V. (2003) · International Journal of Hematology · doi:10.1007/bf02982600 · Cited by 28 · see citing works
“As these chimeras aged, DBA/2 stem cells contributed less and less to hematopoiesis, and the blood became increasingly composed of C57BL/6 cells [ 68 ].”
BackgroundDonnini, A., Re, F., Orlando, F., & Provinciali, M. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0524 · Cited by 26 · see citing works
Autonomous behavior of hematopoietic stem cells
Kamminga, L. M., Akkerman, I., Weersing, E., Ausema, A., Dontje, B., Zant, G. E. V., & de Haan, G. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00543-9 · Cited by 26 · see citing works
Correction of stromal cell defect after bone marrow transplantation in aplastic anaemia
Scopes, J., Ismail, M., Marks, K. J., Rutherford, T. R., Draycott, G. S., Pocock, C., Gordon‐Smith, E. C., & Gibson, F. M. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03134.x · Cited by 25 · see citing works
“The majority of studies have shown that stroma is host in origin after BMT (Wilson et al, 1978; Golde et al, 1980; Laver et al, 1987; Simmons et al, 1987; Perkins & Fleischman, 1988; Athanasou et al, 1990; Agematsu & Nakahori, 1991), although stroma of donor origin has also been demonstrated (Keating et al, 1982; Van…”
BackgroundInfluentialGenetic control of lifespan: studies from animal models
Zant, G. E. V., & de Haan, G. (1999) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399499001441 · Cited by 20 · see citing works
The slippery slope of hematopoietic stem cell aging
Wahlestedt, M., & Bryder, D. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.09.008 · Cited by 18 · see citing works
Characteristics of the hematopoietic stem cell compartment in adult mice
Spangrude, G. J. (1992) · The International Journal Of Cell Cloning · doi:10.1002/stem.5530100505 · Cited by 18 · see citing works
Hematopoietic stem cell development, aging and functional failure
Chen, J. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0856-1 · Cited by 16 · see citing works
“In the chimeras, D2 HSC population was eclipsed by HSCs of the B6 genotype over time, and after 1.5‐3 years, the hemato-lymphoid composition significantly skewed toward the B6 genotype with 30% mice had hematolymphoid populations solely of B6 origin, suggesting age-related HSC functional deficiency in D2 mice [ 66 ].”
BackgroundInfluentialSmith, A. L., Ellison, F. M., McCoy, J. P., & Chen, J. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.4.448 · Cited by 14 · see citing works
“In the B6-D2 allophenic mice, D2 HSCs showed high functionality early in life, but were then eclipsed by HSCs of the B6 genotype (34).”
BackgroundSenescence of Hematopoietic Stem Cells and Bone Marrow Failure
Chen, J. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05094 · Cited by 13 · see citing works
“In B6-D2 allophenic mice, DBA/2 (D2) HSCs had high functionality early, but HSCs of the B6 genotype eclipsed them later in life [ 26 ].”
BackgroundHematopoietic Stem Cells: Self-Renewing or Aging?
de Haan, G. (2002) · Cells Tissues Organs · doi:10.1159/000057689 · Cited by 13 · see citing works
“…has been demonstrated in a series of studies in which stem cells obtained from a mouse strain with a high cell proliferation rate (DBA/2) were competed against stem cells obtained from a mouse strain with a low proliferation rate (C57BL/6) [Van Zant et al., 1990, 1991; Kamminga et al., 2000].”
BackgroundAvagyan, S., Aguiló, F., Kamezaki, K., & Snoeck, H. (2011) · Blood · doi:10.1182/blood-2011-07-365080 · Cited by 12 · see citing works
Stem Cells and Genetics in the Study of Development, Aging, and Longevity
Zant, G. E. V. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_11 · Cited by 12 · see citing works
QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects
Johannes, F. M., Blizard, D. A., Lionikas, A., Lang, D., Vandenbergh, D. J., Stout, J. T., Strauss, J. A., McClearn, G. E., & Vogler, G. P. (2006) · Mammalian Genome · doi:10.1007/s00335-006-0009-7 · Cited by 11 · see citing works
“The B6D2F2 animals were genotyped at 96 microsatellite markers distributed throughout the autosomes and the X chromosome at an average spacing of 15 20 cM. Genotyping was performed as described by Vandenbergh et al. (2003).”
BackgroundInfluentialHematopoiesis during development, aging, and disease
Jung, J., Buisman, S. C., & de Haan, G. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.05.007 · Cited by 10 · see citing works
“In a series of elegant experiments, partly published in Experimental Hematology, Gary Van Zant and his co-workers reported that, in fact, hematopoietic stem cells do age [2]; the rate of aging is related to their (strain-dependent) proliferative activity [3]; and stem cell quiescence is reversible [4].”
BackgroundIn utero transplantation of haemopoietic stem cells
Flake, A. W. (2001) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.2001.0166 · Cited by 10 · see citing works
Mechanisms of Stem Cell Ageing
Waterstrat, A., Oakley, E. J., Miller, A. R., Swiderski, C. F., Liang, Y., & Zant, G. E. V. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_6 · Cited by 8 · see citing works
Lynch, M. (2004) · Rejuvenation Research · doi:10.1089/1549168041553008 · Cited by 8 · see citing works
Polycomb group proteins in hematopoietic stem cell aging and malignancies
Klauke, K., & de Haan, G. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0857-0 · Cited by 7 · see citing works
The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases
Shizuru, J. A. (2015) · doi:10.1002/9781118416426.ch18 · Cited by 7 · see citing works
Mouse Models of Human Blood Cancers
Li, S. (2008) · Springer eBooks · doi:10.1007/978-0-387-69132-9 · Cited by 6 · see citing works
The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function
Brown, A., Schuetz, D., Han, Y., Daria, D., Nattamai, K., Eiwen, K., Sakk, V., Pospiech, J., Saller, T., Zant, G. E. V., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.213009 · Cited by 4 · see citing works
Genetic factors influencing murine hematopoietic productivity in culture
Phillips, R. L., Couzens, M. S., & Zant, G. E. V. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041640113 · Cited by 3 · see citing works
“…output was greatly increased over that of C57BLi6J in these cultures is in agreement with our earlier in vivo data from allophenic mice (Van Zant et al., 1990; Phillips et al., 1992) indicating that DBAiBJ marrow, because of some inherent kinetic advantage, dominates competitive…”
BackgroundResultLebensdauer: Genetische Determinierung und lebensverlängernde Strategien
Niedermüller, H., & Hofecker, G. (2004) · Springer eBooks · doi:10.1007/978-3-642-18741-4_2 · Cited by 3 · see citing works
Hematopoietic stem cells and aging
Zant, G. E. V., Manning, E., & Geiger, H. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)09042-9 · Cited by 2 · see citing works
Lympho-Hematopoietic Stem Cells and Their Aging
Geiger, H., & Zant, G. E. V. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_30 · Cited by 1 · see citing works
“Comparing the engraftment properties of HSCs from various aged mouse inbred strains revealed that there are considerable differences in the rate of which stem cell self-renewal activity is reduced in aged animals, suggesting a strong genetic regulation of stem cell aging ( Van Zant et al. 1990 ; Chen et al. 2000 ; Che…”
BackgroundThe Anemia of Inflammation/Chronic Disease and the Unexplained Anemia of the Elderly
Means, R. T. (2018) · Springer eBooks · doi:10.1007/978-3-319-96487-4_9 · Cited by 1 · see citing works
STEM CELLS AND REPARATIVE REGENERATION IN POSTNATAL ONTOGENESIS OF MAMMALS
Aa, S., Shevlyuk, N. N., Aa, S., & Шевлюк, Н. Н. (2006) · Morphology · doi:10.17816/morph.402516 · Cited by 1 · see citing works
T Lymphocytes of Allophenic Mice Do Not Reject Spleen Colony-Forming Units of the Parental Genotypes
Fedorov, L. M., & Panteleev, E. I. (2000) · Stem Cells and Development · doi:10.1089/152581600419198 · Cited by 1 · see citing works
Hematopoietic Stem Cells, Aging, and Cancer
Bell, D. R., & Zant, G. E. V. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50007-8 · Cited by 1 · see citing works
Dietary Restriction: A Model System Probing the Cell Fate Decision Between Cancer and Senescence
Ertl, R. P., & Harrison, D. E. (2008) · Springer eBooks · doi:10.1007/978-0-387-69132-9_6
Yates, J. L. (2006) · UKnowledge (University of Kentucky)
GENETIC REGULATION OF HEMATOPOIETIC STEM CELL NUMBERS IN MICE
Liang, Y. (2005) · UKnowledge (University of Kentucky)
Ziegler, N. (2010) · Loyola eCommons (Loyola University of Chicago)
GENETIC REGULATION OF HEMATOPOIETIC STEM CELL AGING
Oakley, E. J. (2008) · UKnowledge (University of Kentucky)
Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging
Coutu, D. L., & Galipeau, J. (2013) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-4614-9569-7_17
Hematopoietic Stem Cell Aging and Leukemogenesis
Henry, C. J., Rozhok, A. I., & DeGregori, J. V. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_13
Bystrykh, L. V., Weersing, E., Dontje, B., Geiger, H., Ivanova, N. B., Lemischka, [. V., Vellenga, E., Zant, G. E. V., & de Haan, G. (n.d.) · University of Groningen research database (University of Groningen / Centre for Information Technology)
The Role of Cbx Proteins in Human Benign and Malignant Hematopoiesis
Jung, J., Schepers, H., Lazare, S., Buisman, S. C., Weersing, E., Dethmers-Ausema, B., Klauke, K., Bystrykh, L., & de Haan, G. (2016) · Blood · doi:10.1182/blood.v128.22.2651.2651
Stem cells and fundamental problems of classical histology
Shevlyuk, N. N., Aa, S., & Umbetov, T. Z. (2020) · Morphology · doi:10.17816/1026-3543-2020-158-6-139-150
Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis
Prockop, D. J. (1997) · Springer eBooks · doi:10.1007/978-3-662-03509-2_7
- Authors
- Van Zant, G., Holland, B. P., Eldridge, P. W., & Chen, J. J.
- Affiliations
- Department of Cell Biology and Anatomy, Texas Tech University Health Sciences Center, Lubbock 79430.
- Texas Tech University Health Sciences Center (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-05-01
- Volume
- 171
- Issue
- 5
- Pages
- 1547-1565
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2187897
- OpenAlex
- W2166846044
- Cited by
- 99
- References
- 29
- Citations by year
- 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca040575-10)
- National Cancer Institute (CA40575)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cells, hematopoietic chimeras, stem cell aging, stem cell proliferation, CFU-S, CFU-E, BFU-E, CFU-GM, CFU-GEMM, hematopoietic recovery, mesenchymal stem cells
- MeSH terms
- Aging, Animals, Cells, Cultured, Chimera, Colony-Forming Units Assay, Embryo, Mammalian, Genotype, Hematopoietic Stem Cells, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Bone Marrow Transplantation, Mice
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