Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene
Open accessAbstract
We evaluated in vivo interactions between extrinsic (growth factor induced) and intrinsic (genetically determined) effectors of mouse primitive hemopoietic stem cell proliferation and numbers. Accordingly, stem cell frequency and cell cycle kinetics were assessed in eight strains of inbred mice using the cobblestone area-forming cell (CAFC) assay. A strong inverse correlation was observed between mouse lifespan and the number of autonomously cycling progenitors (CAFC day 7) in the femur. The population size of primitive stem cells (CAFC day 35) varied widely (up to sevenfold) among strains, unlike total CAFC day 7 numbers (cycling and quiescent), which were similar. Administration of the early acting cytokine flt-3 ligand to these strains resulted in activation of quiescent primitive stem cells exclusively in strains with high endogenous stem cell numbers (DBA and AKR), but was unrelated to strain-specific progenitor cell cycling. To map loci affecting stem cell frequency, we quantified stem cells in BXD recombinant inbred mice (offspring of C57BL/6 and DBA/2). The resulting strain distribution pattern showed high concordance with a marker that mapped to chromosome 18 (19 cM). Linkage with this genomic interval was associated with a likelihood of odds score of 3.3, surpassing the level required for significance. Interestingly, this segment, containing the EGR-1 gene, shows synteny with human chromosome 5q, a region strongly associated with various hematological malignancies. Our findings indicate that a gene mapping to this region is mutated in either C57BL/6 or DBA/2 (and possibly AKR) mice. These studies in apparently healthy mice may facilitate the identification of a gene implicated in human 5q-syndromes.
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Aging of the hematopoietic system differs at least qualitatively among mouse strains.
“aging (also of the hematopoietic system) is at least qualitatively different in distinct strains of mice.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [31]
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“Various intrinsic and extrinsic stimuli and their cross-talk were documented as the important factors controlling the stemness of cancer cells (57, 58).”
BackgroundThe role of apoptosis in regulating hematopoietic stem cell numbers
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“In this study, we have identified 2 significant traits involving the hematopoietic stem and progenitor cell compartment that show quantitative variation: (1) responsiveness to early-acting hematopoietic cytokines and (2) absolute number of Lin Sca1 cells (both c-kit and c-kit subpopulations).”
Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous
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Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2
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Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization
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“K; Cross et al., 1995).”
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Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
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The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice
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Mouse Strain Determines Cardiac Growth Potential
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“DBA/2 mice had a greater number of primitive hematopoietic stem cells at a young age than C57BL/6 mice [22].”
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Genetic Control of Stem Cells: Implications for Aging
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“Studies in my laboratory [ 51 ,52,55] and by Morrison et al [54] in which a functional stem cell assay and a flow cytometric phenotype assay, respectively, were used showed that Stem Cell Genetics 33”
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“compared to young HSCs [5–13].”
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“Genetic analyses have shown that the differing levels of CFU-GM mobilization between the C57BL/6J and BALB/c mice are linked to several discrete genetic loci within the genome of these inbred strains and is correlated with the size of their respective stem cell pools (41, 48, 49).”
BackgroundAutonomous behavior of hematopoietic stem cells
Kamminga, L. M., Akkerman, I., Weersing, E., Ausema, A., Dontje, B., Zant, G. E. V., & de Haan, G. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00543-9 · Cited by 26 · see citing works
The Cobblestone-Area-Forming Cell Assay
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“[17], who showed up to 20% donor chimerism in unconditioned BALB/c mice transplanted with 40 106 fresh marrow cells, we observed little donor chimerism in 100-cGy conditioned C57 hosts transplanted with up to 36 106 fresh marrow cells, which likely reflects strain-specific differences in sensitivity to radiation, as w…”
Primitive hematopoietic stem cell function in vivo is uniquely high in the CXB-12 mouse strain
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Isolation and Analysis of Hematopoietic Stem Cells from Mouse Embryos
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A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics
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“Mice are known to exhibit strain-related differences in hematopoietic progenitor cell numbers and kinetics [35–37] and it is possible that Fas-related effects may be more apparent against some genetic backgrounds than others.”
BackgroundRecent progress in identifying genes regulating hematopoietic stem cell function and fate
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Genetic Influences in Mouse Spermatogonial Stem Cell Self-Renewal
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“For example, studies in the hematopoietic system have revealed fundamental differences between the mechanisms that control the frequency of HSCs and those that regulate mature blood cell numbers [15].”
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Stem cell traits in long-term co-culture revealed by time-lapse imaging
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“Rather, the appearance of CAs at different time points is correlated with the hierarchy of the hematopoietic cells as also indicated in previous studies by others (20).”
Aging Effects on Cardiac Progenitor Cell Physiology
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“Genetical genomics”
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Characterization of cytokine interactions by flow cytometry and factorial analysis
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“These strain differences were the groundwork for genetic analyses that defined several quantitative trait loci that regulate HSC senescence (4,8,9).”
BackgroundBrauner, P., Nibbelink, M. M., Flachs, P., Vítková, I., Kopecky, P., Mertelíková, I., Rossmeislová, L., Pénicaud, L., Casteilla, L., Plavka, R., et al. (2001) · Pediatric Research · doi:10.1203/00006450-200103000-00022 · Cited by 13 · see citing works
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“The underlying mechanism of poor mobilization in these individuals is unclear however mouse studies have demonstrated putative genes on chromosomes 2 and 11 that affect mobilization proficiency [38] and overall stem cell pool size [39-41].”
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Natural Genetic Diversity as a Means to Uncover Stem Cell Regulatory Pathways
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Latexin is a newly discovered regulator of hematopoietic stem cells
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“The CAFC assay can be used as a limiting dilution assay for stem cells, and it has been shown that day 8 CAFC correlate with day 12 colony forming unit-spleen (CFU-S), whereas day 28 CAFC correlate with the more primitive pre-CFU-S [60].”
BackgroundInfluentialStem Cells and Genetics in the Study of Development, Aging, and Longevity
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“Similarly, QTL have been identified that determine mouse stem, progenitor and mature white blood cell numbers [10-18].”
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Mechanisms of Stem Cell Ageing
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Polycomb group proteins in hematopoietic stem cell aging and malignancies
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“To uncover genes that are responsible for the differences in HSC frequency and turnover, gene expression profiling of recombinant inbred strains from DBA/2 and C57Bl/6 was conducted [87–90].”
Method
- Authors
- Haan, G. D., & Zant, G. V.
- Affiliations
- University of Kentucky HealthCare (US)
- From the Blood and Marrow Transplant Program, Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington, Kentucky 40536-0093
- ORCID
- Haan, Gerald de
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-08-18
- Volume
- 186
- Issue
- 4
- Pages
- 529-536
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2199035
- OpenAlex
- W2115154817
- Cited by
- 134
- References
- 33
- Citations by year
- 2020: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 6 · 2013: 3 · 2012: 3
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc-sa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cells, stem cell frequency, Flt3 ligand, stem cell quiescence, cell cycle kinetics, cobblestone area-forming cells, BXD recombinant inbred mice, linkage mapping, chromosome 18, EGR1, 5q- syndrome, mouse strain differences, mouse lifespan
- MeSH terms
- Animals, Cell Count, Cell Division, Chromosome Mapping, Female, Hematopoietic Stem Cells, Humans, Mice, Inbred Strains, Species Specificity, Mice
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