The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.
Open accessAbstract
Human resting B lymphocytes enter a state of sustained proliferation when incubated with both mouse fibroblastic L cells stably expressing Fc gamma RII/CDw32 and anti-CD40 antibodies. We have explored the effects of 11 recombinant human cytokines (CKs) on induced cell proliferation and immunoglobulin (Ig) production. Interleukin 4 (IL-4) was the only CK able to enhance anti-CD40-induced B cell multiplication as measured by enumeration of viable cells, and interferon gamma (IFN-gamma) further stimulated this induced proliferation. IL-4 enhanced the production of IgM and IgG by B cells and induced them to produce IgE. Combinations of IL-4 and IL-2 resulted in the production of large amounts of IgM and IgA. Interestingly, IFN-gamma did not inhibit the production of IgE by cells stimulated with anti-CD40 and IL-4. None of the tested CK combinations resulted in the production of large quantities of IgG. Therefore, this new culture system represents a unique model to study isotype regulation in highly purified human B lymphocytes, in addition to allowing the generation of long-term factor-dependent human B cell lines.
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Pène, J., Rousset, F., Brière, F., Chrétien, I., Bonnefoy, J. Y., Spits, H., Yokota, T., Arai, N., Arai, K., & Banchereau, J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6880 · Cited by 924
Self-citationB cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
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Self-citationEffect of tumor necrosis factor alpha on mitogen-activated human B cells.
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Activation of human B lymphocytes through CD40 and interleukin 4
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Self-citationB cell growth-promoting activity of recombinant human interleukin 4.
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Cited by
Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647
Activation of human dendritic cells through CD40 cross-linking.
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Self-citationInterleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Self-citationDefrance, T., Vanbervliet, B., Brière, F., Durand, I., Rousset, F., & Banchereau, J. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.3.671 · Cited by 638
Self-citationZumaquero, E., Stone, S. L., Scharer, C. D., Jenks, S. A., Nellore, A., Mousseau, B., Rosal-Vela, A., Botta, D., Bradley, J. E., Wojciechowski, W., et al. (2019) · eLife · doi:10.7554/elife.41641 · Cited by 189
Metadata
- Authors
- Rousset, F., Garcia, E., & Banchereau, J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-03-01
- Volume
- 173
- Issue
- 3
- Pages
- 705-710
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1989692667
- Cited by
- 329
- References
- 14
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- green
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