The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of tumor necrosis factor alpha on mitogen-activated human B cells.
Open accessAbstract
In this study we demonstrate that the monocyte/macrophage product, tumor necrosis factor alpha (TNF-alpha), has significant in vitro effects of B cell function. It costimulated with anti-mu in the induction of B cell DNA synthesis, and it prolonged the DNA synthesis initiated in B cell cultures stimulated with the human B cell mitogen, Staphylococcus aureus Cowan strain I (SAC). The addition of either IL-1 or IFN-gamma to TNF-alpha resulted in a substantial further increase in DNA synthesis. The addition of TNF-alpha to IL-2, a known inducer of SAC-activated B cell Ig secretion, resulted in a twofold enhancement in the amount of IL-2 stimulated B cell Ig secretion. Receptor binding studies with 125I-TNF-alpha demonstrate a marked increase in TNF-alpha binding sites after B cell activation (approximately 6,000 sites per cell, with an apparent Kd of 2.0 X 10(-10) M). Thus, TNF-alpha may be an important factor in human B cell function and is likely to interact with other T cell and monocyte derived cytokines in the regulation of human B cell proliferation and Ig production.
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Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Cited by
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Poli, G., Kinter, A., Justement, J. S., Kehrl, J. H., Bressler, P., Stanley, S., & Fauci, A. S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.782 · Cited by 457
Self-citationRousset, F., Garcia, E., & Banchereau, J. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.3.705 · Cited by 329
Cope, A. P., Londei, M., Chu, N. R., Cohen, S. B., Elliott, M. J., Brennan, F. M., Maini, R. N., & Feldmann, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117394 · Cited by 243
Proteolytic inactivation of cytokines by Pseudomonas aeruginosa
Parmely, M., Gale, A., Clabaugh, M., Horvat, R., & Zhou, W. W. (1990) · Infection and Immunity · doi:10.1128/iai.58.9.3009-3014.1990 · Cited by 181
Metadata
- Authors
- Kehrl, J. H., Miller, A., & Fauci, A. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-09-01
- Volume
- 166
- Issue
- 3
- Pages
- 786-791
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2095343750
- Cited by
- 236
- References
- 1
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kehrl, J. H., Miller, A., & Fauci, A. S. (1987). Effect of tumor necrosis factor alpha on mitogen-activated human B cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.166.3.786
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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