The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Most peripheral B cells in mice are ligand selected.
Open accessAbstract
Using amplified cDNA and genomic libraries, we have analyzed the VH gene repertoire of pre-B cells and various B cell subsets of conventional mice at the level of VH genes belonging to the J558 VH gene family. The sequence data were evaluated on the basis of a newly established list of 67 J558 VH genes that comprise approximately two-thirds of the J558 VH genes of the murine IgHb haplotype. The results of the analysis demonstrate that VH gene utilization in pre-B cells, although biased to some extent by B cell autonomous VH gene selection, scatters over the whole range of J558 VH genes present in the germline. In contrast, in mature, peripheral B cells comprising long-lived mu + delta high B cells as well as Ly-1 B cells, small overlapping sets of germline VH genes are dominantly expressed. The data indicate that the recruitment of newly generated B cells into the long-lived peripheral B cell pool is mediated through positive selection by internal and/or external antigens. Because of the absence of immunoglobulin class switching and somatic hypermutation, this process is different from the selection of memory B cells in T cell-dependent immune responses.
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Cites
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Cited by
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Population Biology of Lymphocytes: The Flight for Survival
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Metadata
- Authors
- Gu, H., Tarlinton, D., Müller, W., Rajewsky, K., & Förster, I.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-06-01
- Volume
- 173
- Issue
- 6
- Pages
- 1357-1371
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2036859226
- Cited by
- 417
- References
- 37
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Gu, H., Tarlinton, D., Müller, W., Rajewsky, K., & Förster, I. (1991). Most peripheral B cells in mice are ligand selected. The Journal of experimental medicine. https://doi.org/10.1084/jem.173.6.1357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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