The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.
Open accessAbstract
The human immunodeficiency virus (HIV) binds to the surface of T lymphocytes and other cells of the immune system via a high affinity interaction between CD4 and the HIV outer envelope glycoprotein, gp120. By analogy with certain other enveloped viruses, receptor binding by HIV may be followed by exposure of the hydrophobic NH2 terminus of its transmembrane glycoprotein, gp41, and fusion of the virus and cell membranes. A similar sequence of events is thought to take place between HIV-infected and uninfected CD4+ cells, resulting in their fusion to form syncytia. In this study, we have used a soluble, recombinant form of CD4 (sCD4) to model events taking place after receptor binding by the HIV envelope glycoproteins. We demonstrate that the complexing of sCD4 with gp120 induces conformational changes within envelope glycoprotein oligomers. This was measured on HIV-1-infected cells by the increased binding of antibodies to the gp120/V3 loops, and on the surface of virions by increased cleavage of this loop by an exogenous proteinase. At 37 degrees C, these conformational changes are coordinate with the dissociation of gp120/sCD4 complexes from gp41, and the increased exposure of gp41 epitopes. At 4 degrees C, gp120 dissociation from the cell surface does not occur, but increased exposure of both gp120/V3 and gp41 epitopes is detected. We propose that these events occurring after CD4 binding are integral components of the membrane fusion reaction between HIV or HIV-infected cells and CD4+ cells.
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Cites
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
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Self-citationAtomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
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Cited by
Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., & Kappes, J. C. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1896-1905.2002 · Cited by 1,569
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HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse
Jolly, C., Kashefi, K., Hollinshead, M., & Sattentau, Q. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030648 · Cited by 623
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Self-citationVIRUS-CELL AND CELL-CELL FUSION
Hernandez, L. D., Hoffman, L. R., Wolfsberg, T. G., & White, J. M. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.627 · Cited by 567
Metadata
- Authors
- Sattentau, Q. J., & Moore, J. P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-08-01
- Volume
- 174
- Issue
- 2
- Pages
- 407-415
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2117798874
- Cited by
- 600
- References
- 41
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Sattentau, Q. J., & Moore, J. P. (1991). Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.2.407
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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