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Cited by 334

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.

Open access
Kita, H, Ohnishi, T, Okubo, Y, Weiler, D, Abrams, J S, Gleich, G J·1991·The Journal of experimental medicine

Abstract

Human peripheral blood eosinophils released eosinophil survival-enhancing activity when stimulated with the calcium ionophore, ionomycin. The release of activity was detected as early as 3 h after stimulation and was inhibited by an immunomodulating agent, cyclosporin A. The survival-enhancing activity was completely abolished by treatment with anti-interleukin 3 (IL-3) and anti-granulocyte/macrophage colony-stimulating factor (GM-CSF) monoclonal antibodies. Moreover, IL-3 and GM-CSF were measurable in ionomycin-stimulated eosinophil supernatants by immunoassay. Eosinophils produced approximately one-half as much IL-3 and one-fifth as much GM-CSF as ionomycin-stimulated mononuclear cells. Neutrophils also produced IL-3 and GM-CSF, but the amounts were less than those produced by eosinophils. These observations suggest a novel role for eosinophils in pathophysiology of allergic inflammation and host defense mechanisms.

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Crossref · 10.1084/jem.174.3.745

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Metadata

Authors
Kita, H., Ohnishi, T., Okubo, Y., Weiler, D., Abrams, J. S., & Gleich, G. J.
Venue
The Journal of experimental medicine
Published
1991-09-01
Volume
174
Issue
3
Pages
745-748
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W2162248888
Cited by
334
References
2
FWCI
19.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. https://app.cochat.ai/papers/10.1084/jem.174.3.745
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Kita, H., Ohnishi, T., Okubo, Y., Weiler, D., Abrams, J. S., & Gleich, G. J. (1991). Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.3.745

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.