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Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.
Open accessAbstract
Transgenic mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption and normal mice that had been treated with a CD8-specific mAb were infected intranasally with an H3N2 influenza A virus. Both groups of CD8T cell-deficient mice eliminated the virus from the infected respiratory tract. Potent CTL activity was detected in lung lavage populations taken from mice with intact CD8+ T cell function, with minimal levels of cytotoxicity being found for inflammatory cells obtained from the antibody-treated and beta 2-m mutant mice. We therefore conclude that cells infected with an influenza A virus can be cleared from the respiratory tract of mice lacking both functional class I major histocompatibility complex (MHC) glycoproteins and class I MHC-restricted, CD8+ effector T cells.
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Citations
Cited by
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Gornalusse, G. G., Hirata, R. K., Funk, S. E., Riolobos, L., Lopes, V. S., Manske, G., Prunkard, D., Colunga, A. G., Hanafi, L.-A., Clegg, D. O., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3860 · Cited by 639
Restifo, N. P., Marincola, F. M., Kawakami, Y., Taubenberger, J., Yannelli, J. R., & Rosenberg, S. A. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.100 · Cited by 533
T cell-mediated immune response to respiratory coronaviruses
Channappanavar, R., Zhao, J., & Perlman, S. (2014) · Immunologic Research · doi:10.1007/s12026-014-8534-z · Cited by 512
Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections
Doherty, P. C., Topham, D. J., Tripp, R. A., Cardin, R. D., Brooks, J. W., & Stevenson, P. G. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01010.x · Cited by 428
Self-citationvon Herrath, M. G., Yokoyama, M., Dockter, J., Oldstone, M. B., & Whitton, J. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.1072-1079.1996 · Cited by 279
Metadata
- Authors
- Eichelberger, M., Allan, W., Zijlstra, M., Jaenisch, R., & Doherty, P. C.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1991-10-01
- Volume
- 174
- Issue
- 4
- Pages
- 875-880
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2140279098
- Cited by
- 366
- References
- 0
- FWCI
- 20.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. https://app.cochat.ai/papers/10.1084/jem.174.4.875
- The paper
- Eichelberger, M., Allan, W., Zijlstra, M., Jaenisch, R., & Doherty, P. C. (1991). Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.174.4.875
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
