Cited by 358Chemokine receptors and signalingInflammation biomarkers and pathwaysS100 Proteins and Annexins

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Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8

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Walz, A, Burgener, R, Car, B, Baggiolini, M, Kunkel, S L, Strieter, R M·1991·The Journal of experimental medicine

DOI 10.1084/jem.174.6.1355PMC PMC2119025

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Abstract

A new neutrophil-activating peptide, termed ENA-78, was identified in the conditioned media of stimulated human type II epithelial cell line A549. In response to stimulation with either interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF-alpha), ENA-78 was produced and secreted concomitantly with IL-8, GRO alpha, and GRO gamma. ENA-78 consists of 78 amino acids [sequence; see text] and has a molecular weight of 8,357. It has four cysteines positioned identically to those of IL-8 and analogues, and thus belongs to the CXC family of peptides. ENA-78 is related to neutrophil-activating peptide 2 (NAP-2) and GRO alpha (sequence identity, 53% and 52%, respectively) and IL-8 (22% identity). Like NAP-2 and GRO alpha, ENA-78 stimulates neutrophils, inducing chemotaxis, a rise in intracellular free calcium and exocytosis. Cross-desensitization experiments indicate that ENA-78 acts through the same type of receptors as IL-8, NAP-2, and GRO alpha.

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Authors: Walz, A., Burgener, R., Car, B., Baggiolini, M., Kunkel, S. L., & Strieter, R. M.
Affiliations: University of Bern (CH)
ORCID: Kunkel, S L
Strieter, R M
Venue: The Journal of experimental medicine
Publisher: Rockefeller University Press
Published: 1991-12-01
Volume: 174
Issue: 6
Pages: 1355-1362
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.174.6.1355
PMC: PMC2119025
OpenAlex: W1970155928
Cited by: 353
References: 39
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 12 · 2013: 14 · 2012: 8
FWCI: 7.71
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08hl002401-03, 5r01hl031237-32)
National Heart, Lung, and Blood Institute (HL-02401, HL31237)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords: CXCL5, CXC chemokines, interleukin-8, neutrophil chemotaxis, IL-1β, TNF-α, A549 cells, intracellular calcium, exocytosis
MeSH terms: Amino Acid Sequence, Base Sequence, beta-Thromboglobulin, Calcium, Cell Line, Humans, Molecular Sequence Data, Neutrophils, Peptides, Interleukin-8, Chemokines, CXC, Chemokine CXCL5

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Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8

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