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Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.
Open accessAbstract
To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections.
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Citations
Cited by
Cell-mediated Protection in Influenza Infection
Thomas, P. G., Keating, R., Hulse-Post, D. J., & Doherty, P. C. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.051237 · Cited by 466
The CD8 T Cell Response to Respiratory Virus Infections
Schmidt, M. E., & Varga, S. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00678 · Cited by 371
Defense Mechanisms against Influenza Virus Infection in the Respiratory Tract Mucosa
Tamura, S.-I., & Kurata, T. (2004) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2004.236 · Cited by 276
Grebe, K. M., Takeda, K., Hickman, H. D., Bailey, A. M., Embry, A. C., Bennink, J. R., & Yewdell, J. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903395 · Cited by 130
PPAR-γ Activation As an Anti-inflammatory Therapy for Respiratory Virus Infections
Bassaganya-Riera, J., Song, R., Roberts, P. C., & Hontecillas, R. (2010) · Viral Immunology · doi:10.1089/vim.2010.0016 · Cited by 83
Metadata
- Authors
- Bender, B. S., Croghan, T., Zhang, L., & Small, P. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1992-04-01
- Volume
- 175
- Issue
- 4
- Pages
- 1143-1145
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2109916423
- Cited by
- 381
- References
- 0
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. https://app.cochat.ai/papers/10.1084/jem.175.4.1143
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- Bender, B. S., Croghan, T., Zhang, L., & Small, P. A. (1992). Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. The Journal of experimental medicine. https://doi.org/10.1084/jem.175.4.1143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
