Cited by 84Peroxisome Proliferator-Activated ReceptorsRespiratory viral infections researchinterferon and immune responses

PPAR-γ Activation As an Anti-inflammatory Therapy for Respiratory Virus Infections

Bassaganya-Riera, Josep, Song, Rong, Roberts, Paul C., Hontecillas, Raquel·2010·Viral Immunology

Abstract

Newly emerged influenza viruses have attracted extensive attention due to their high infectivity, proinflammatory actions, and potential to induce worldwide pandemics. Frequent mutations and gene reassortments between viruses complicate the development of protective vaccines and antiviral therapeutics. In contrast, targeting the host response for the development of novel cost-effective, broad-based prophylactic or therapeutic agents holds greater promise. Since inflammation often parallels the development of productive immune responses, virus-induced pulmonary inflammation and injury represents an additional challenge to the development of broad-based immunotherapeutics. Excessive inflammatory responses to respiratory viruses, also known as "cytokine storm," are largely due to immune dysregulation that manifests as proinflammatory cytokine secretion. In addition to modulating lipid and glucose metabolism, peroxisome proliferator-activated receptors (PPAR) play important roles in antagonizing core inflammatory pathways such as NF-kappaB, AP1, and STAT. Their role in regulating inflammatory responses caused by pulmonary pathogens is receiving increasing attention, setting the stage for the discovery of novel applications for anti-diabetic and lipid-lowering drugs. This review focuses on the potential use of PPAR-gamma agonists to downregulate the inflammatory responses to respiratory virus-related pulmonary inflammation.

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Registry

Crossref · 10.1089/vim.2010.0016

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120 of 120 references verified0 citation errors · 0 not checkable

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  • PPAR-gamma agonists downregulate the inflammatory response to virus-induced lung inflammation.

    “PPAR-␥ agonists downregulate the inflammatory response to virus-induced lung inflammation (8).”

    From Into the Eye of the Cytokine Storm (2012) · cites this paper as [8]

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Authors
Bassaganya-Riera, J., Song, R., Roberts, P. C., & Hontecillas, R.
Affiliations
  • NIMML Institute (US)
  • Virginia–Maryland College of Veterinary Medicine (US)
Corresponding author
Hontecillas, Raquel
Venue
Viral Immunology
Published
2010-08
Volume
23
Issue
4
Pages
343-352
ISSN
  • 0882-8245 (ISSN-L)
  • 1557-8976
OpenAlex
W1978334109
Cited by
83
References
119
Citations by year
2026: 3 · 2025: 2 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 16 · 2020: 11 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 10
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • Viral Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
PPARγ, PPARγ agonists, anti-inflammatory therapy, respiratory viral infections, influenza virus, cytokine storm, lung inflammation, host-directed therapy, NF-κB, STAT signaling, AP-1, inflammatory cytokines, antidiabetic drugs, lipid-lowering drugs
MeSH terms
Anti-Inflammatory Agents, Chronic Disease, Humans, Influenza, Human, Respiratory Tract Infections, Down-Regulation, PPAR gamma

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