The CD8 T Cell Response to Respiratory Virus Infections

Schmidt, Megan E.; Varga, Steven M.

doi:10.3389/fimmu.2018.00678

Cited by 371Respiratory viral infections researchT-cell and B-cell ImmunologySARS-CoV-2 and COVID-19 Research

The CD8 T Cell Response to Respiratory Virus Infections

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Schmidt, Megan E., Varga, Steven M.·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.00678PMC PMC5900024

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Abstract

Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the common cold, many respiratory viruses induce severe bronchiolitis, pneumonia, and even death following infection. Despite the immense clinical burden, the majority of the most common pulmonary viruses lack long-lasting efficacious vaccines. Nearly all current vaccination strategies are designed to elicit broadly neutralizing antibodies, which prevent severe disease following a subsequent infection. However, the mucosal antibody response to many respiratory viruses is not long-lasting and declines with age. CD8 T cells are critical for mediating clearance following many acute viral infections in the lung. In addition, memory CD8 T cells are capable of providing protection against secondary infections. Therefore, the combined induction of virus-specific CD8 T cells and antibodies may provide optimal protective immunity. Herein, we review the current literature on CD8 T cell responses induced by respiratory virus infections. Additionally, we explore how this knowledge could be utilized in the development of future vaccines against respiratory viruses, with a special emphasis on RSV vaccination.

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It is likely that CD8+ T cells contribute to viral clearance in tissues.
“Although the correlates of protection in this study were binding and neutralizing antibody titres34,35, it is likely that CD8+ T cells contribute to viral clearance in tissues36,37.”
From Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine (2022) · cites this paper as [37]

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[102]Hussell T Pennycook A Openshaw PJ. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol (2001) 31(9): 2566– 73. 10.1002/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L 11536154 · DOI

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Authors: Schmidt, M. E., & Varga, S. M.
Affiliations: University of Iowa (US)
Corresponding author: Varga, Steven M.
ORCID: Schmidt, Megan E.
Varga, Steven M.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-04-09
Volume: 9
Pages: 678-678
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.00678
PMC: PMC5900024
OpenAlex: W2796489672
Cited by: 371
References: 142
Citations by year: 2026: 24 · 2025: 31 · 2024: 29 · 2023: 62 · 2022: 56 · 2021: 84 · 2020: 61 · 2019: 19 · 2018: 5
FWCI: 6.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (R01AI124093, T32AI007485)
Topics: Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: CD8+ T cells, respiratory viruses, respiratory syncytial virus, influenza virus, human metapneumovirus, rhinovirus, coronavirus, parainfluenza virus, memory CD8+ T cells, mucosal immunity, vaccine development, RSV vaccination, age-related antibody decline
MeSH terms: Animals, Humans, Respiratory Tract Diseases, Virus Diseases, CD8-Positive T-Lymphocytes

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The CD8 T Cell Response to Respiratory Virus Infections

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