The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.
Open accessAbstract
Epstein-Barr virus (EBV) is associated with a number of different human tumors and appears to play different pathogenetic roles in each case. Thus, immunoblastic B cell lymphomas of the immunosuppressed display the full pattern of EBV latent gene expression (expressing Epstein-Barr nuclear antigen [EBNA]1, 2, 3A, 3B, 3C, and -LP, and latent membrane protein [LMP]1, 2A, and 2B), just as do B lymphoblastoid cell lines transformed by the virus in vitro. In contrast, those EBV-associated tumors with a more complex, multistep pathogenesis show more restricted patterns of viral gene expression, limited in Burkitt's lymphoma to EBNA1 only and in nasopharyngeal carcinoma (NPC) to EBNA1 and LMP1, 2A, and 2B. Recent evidence has implicated EBV in the pathogenesis of another lymphoid tumor, Hodgkin's disease (HD), where the malignant Hodgkin's and Reed-Sternberg (HRS) cells are EBV genome positive in up to 50% of cases. Here we extend preliminary results on viral gene expression in HRS cells by adopting polymerase chain reaction-based and in situ hybridization assays capable of detecting specific EBV latent transcripts diagnostic of the different possible forms of EBV latency. We show that the transcriptional program of the virus in HRS cells is similar to that seen in NPC in several respects: (a) selective expression of EBNA1 mRNA from the BamHI F promoter; (b) downregulation of the BamHI C and W promoters and their associated EBNA mRNAs; (c) expression of LMP1 and, in most cases, LMP2A and 2B transcripts; and (d) expression of the "rightward-running" BamHI A transcripts once thought to be unique to NPC. This form of latency, consistently detected in EBV-positive HD irrespective of histological subtype, implies an active role for the virus in the pathogenesis of HD and also suggests that the tumor may remain sensitive to at least certain facets of the EBV-induced cytotoxic T cell response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cordell, J. L., Falini, B., Erber, W. N., Ghosh, A. K., Abdulaziz, Z., MacDonald, S., Pulford, K. A., Stein, H., & Mason, D. Y. (1984) · Journal of Histochemistry & Cytochemistry · doi:10.1177/32.2.6198355 · Cited by 3,148
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Séguin, C., et al. (1984) · Nature · doi:10.1038/310207a0 · Cited by 2,053
Epstein-Barr virus and its replication
Kieff, E. D. (1996) · Medical Entomology and Zoology · Cited by 1,627
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
Wang, D., Liebowitz, D., & Kieff, E. (1985) · Cell · doi:10.1016/0092-8674(85)90256-9 · Cited by 1,225
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation
Raab-Traub, N., & Flynn, K. (1986) · Cell · doi:10.1016/0092-8674(86)90803-2 · Cited by 912
Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease
Weiss, L. M., Movahed, L. A., Warnke, R. A., & Sklar, J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902233200806 · Cited by 886
Young, L., Alfieri, C., Hennessy, K., Evans, H., O'Hara, C., Anderson, K. C., Ritz, J., Shapiro, R. S., Rickinson, A., Kieff, E., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910193211604 · Cited by 749
Self-citationRowe, M., Rowe, D. T., Gregory, C. D., Young, L. S., Farrell, P. J., Rupani, H., & Rickinson, A. B. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02568.x · Cited by 711
Self-citationWang, F., Gregory, C., Sample, C., Rowe, M., Liebowitz, D., Murray, R., Rickinson, A., & Kieff, E. (1990) · Journal of Virology · doi:10.1128/jvi.64.5.2309-2318.1990 · Cited by 566
Self-citationMurray, R. J., Kurilla, M. G., Brooks, J. M., Thomas, W. A., Rowe, M., Kieff, E., & Rickinson, A. B. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.157 · Cited by 499
Self-citation
Cited by
Epstein-Barr virus-associated Hodgkin's disease: Epidemiologic characteristics in international data
Glaser, S. L., Lin, R. J., Stewart, S. L., Ambinder, R. F., Jarrett, R. F., Brousset, P., Pallesen, G., Gulley, M. L., Khan, G., O'Grady, J., et al. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970207)70:4<375::aid-ijc1>3.0.co;2-t · Cited by 506
Self-citationA Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers
Tan, L. C., Gudgeon, N., Annels, N. E., Hansasuta, P., O’Callaghan, C. A., Rowland-Jones, S., McMichael, A. J., Rickinson, A. B., & Callan, M. F. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1827 · Cited by 499
Self-citationAberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
Jost, P. J., & Ruland, J. (2007) · Blood · doi:10.1182/blood-2006-07-025809 · Cited by 408
Modulation of LMP1 protein expression by EBV-encoded microRNAs
Lo, A. K. F., To, K. F., Lo, K. W., Lung, R. W. M., Hui, J. W. Y., Liao, G., & Hayward, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702896104 · Cited by 356
Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses
Speck, S. H., & Ganem, D. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.06.014 · Cited by 302
Metadata
- Authors
- Deacon, E. M., Pallesen, G., Niedobitek, G., Crocker, J., Brooks, L., Rickinson, A. B., & Young, L. S.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-02-01
- Volume
- 177
- Issue
- 2
- Pages
- 339-349
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2031162215
- Cited by
- 356
- References
- 33
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells. https://app.cochat.ai/papers/10.1084/jem.177.2.339
- The paper
- Deacon, E. M., Pallesen, G., Niedobitek, G., Crocker, J., Brooks, L., Rickinson, A. B., & Young, L. S. (1993). Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.2.339
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
