The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
Open accessAbstract
The transcription factor NF-κB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-κB is required for the coordination of physiologic immune responses. However, constitutive NF-κB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-κB signaling in Hodgkin disease and a variety of T- and B-cell non-Hodgkin lymphomas either upstream or downstream of the central IκB kinase. These alterations are prerequisites for lymphoma cell cycling and blockage of apoptosis. This review provides an overview of the NF-κB pathway and discusses the mechanisms of NF-κB deregulation in distinct lymphoma entities with defined aberrant pathways: Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), mucosa-associated lymphoid tissue (MALT) lymphoma, primary effusion lymphoma (PEL), and adult T-cell lymphoma/leukemia (ATL). In addition, we summarize recent data that validates the NF-κB signaling pathway as an attractive therapeutic target in T- and B-cell malignancies.
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Cites
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Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
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NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation
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Hideshima, T., Chauhan, D., Hayashi, T., Akiyama, M., Mitsiades, N., Mitsiades, C., Podar, K., Munshi, N. C., Richardson, P. G., & Anderson, K. C. (2003) · Oncogene · doi:10.1038/sj.onc.1207170 · Cited by 164
Cited by
Lam, L. T., Wright, G., Davis, R. E., Lenz, G., Farinha, P., Dang, L., Chan, J. W., Rosenwald, A., Gascoyne, R. D., & Staudt, L. M. (2008) · Blood · doi:10.1182/blood-2007-09-111948 · Cited by 353
Milhollen, M. A., Traore, T., Adams-Duffy, J., Thomas, M. P., Berger, A. J., Dang, L., Dick, L. R., Garnsey, J. J., Koenig, E., Langston, S. P., et al. (2010) · Blood · doi:10.1182/blood-2010-03-272567 · Cited by 323
Tumor microenvironment in ovarian cancer: function and therapeutic strategy
Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218
Single-cell biological network inference using a heterogeneous graph transformer
Ma, A., Wang, X., Li, J., Wang, C., Xiao, T., Liu, Y., Cheng, H., Wang, J., Li, Y., Chang, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36559-0 · Cited by 184
Hayashi, K., Taura, M., & Iwasaki, A. (2018) · Science Signaling · doi:10.1126/scisignal.aan4144 · Cited by 76
Metadata
- Authors
- Jost, P. J., & Ruland, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-11-21
- Volume
- 109
- Issue
- 7
- Pages
- 2700-2707
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1988587254
- Cited by
- 408
- References
- 5
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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