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Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.
Open accessAbstract
The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations.
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Cited by
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338
Tan, J. T., Ernst, B., Kieper, W. C., LeRoy, E., Sprent, J., & Surh, C. D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020066 · Cited by 786
Suppressive effects of androgens on the immune system
Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551
Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism
Reya, T., O'Riordan, M., Okamura, R., Devaney, E., Willert, K., Nusse, R., & Grosschedl, R. (2000) · Immunity · doi:10.1016/s1074-7613(00)00004-2 · Cited by 450
B cells responses and cytokine production are regulated by their immune microenvironment
Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421
Metadata
- Authors
- Grabstein, K. H., Waldschmidt, T. J., Finkelman, F. D., Hess, B. W., Alpert, A. R., Boiani, N. E., Namen, A. E., & Morrissey, P. J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-07-01
- Volume
- 178
- Issue
- 1
- Pages
- 257-264
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162743131
- Cited by
- 341
- References
- 0
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. https://app.cochat.ai/papers/10.1084/jem.178.1.257
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- Grabstein, K. H., Waldschmidt, T. J., Finkelman, F. D., Hess, B. W., Alpert, A. R., Boiani, N. E., Namen, A. E., & Morrissey, P. J. (1993). Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. The Journal of experimental medicine. https://doi.org/10.1084/jem.178.1.257
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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