B cells responses and cytokine production are regulated by their immune microenvironment
Open accessAbstract
The adaptive immune system consists of two types of lymphocytes: T and B cells. These two lymphocytes originate from a common precursor, yet are fundamentally different with B cells mediating humoral immunity while T cells mediate cell mediated immunity. In cytokine production, naïve T cells produce multiple cytokines upon activation while naïve activated B cells do not. B cells are capable of producing cytokines, but their cytokine production depends on their differentiation state and activation conditions. Hence, unlike T cells that can produce a large amount of cytokines upon activation, B cells require specific differentiation and activation conditions to produce cytokines. Many cytokines act on B cells as well. Here, we discuss several cytokines and their effects on B cells including: Interleukins, IL-7, IL-4, IL-6, IL-10, and Interferons, IFN-α, IFN-β, IFN-γ. These cytokines play important roles in the development, survival, differentiation and/or proliferation of B cells. Certain chemokines also play important roles in B cell function, namely antibody production. As an example, we discuss CCL28, a chemokine that directs the migration of plasma cells to mucosal sites. We conclude with a brief overview of B cells as cytokine producers and their likely functional consequences on the immune response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Th17 cells are an independent T helper cell subset.
“Th17 cells were established as an independent T helper cell subset with the discovery of signature cytokines IL-17A, IL-17F, and IL-22, lineage-specific differentiation factors, and dedicated or “master” transcription factors”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120 · see citing works
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762 · see citing works
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,185 · see citing works
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888 · see citing works
Self-citationHirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139 · see citing works
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890 · see citing works
BCL-2 FAMILY: Regulators of Cell Death
Chao, D. T., & Korsmeyer, S. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.395 · Cited by 1,686 · see citing works
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
von Freeden-Jeffry, U., Vieira, P., Lucian, L., McNeil, T., Burdach, S. E. G., & Murray, R. (1995) · Journal of Experimental Medicine · doi:10.1084/jem.181.4.1519 · Cited by 1,648 · see citing works
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629 · see citing works
Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.
Iyer, S. S., & Cheng, G. (2012) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v32.i1.30 · Cited by 1,611 · see citing works
Blair, P. A., Noreña, L. Y., Flores-Borja, F., Rawlings, D. J., Isenberg, D. A., Ehrenstein, M. R., & Mauri, C. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.009 · Cited by 1,574 · see citing works
Essential role of Stat6 in IL-4 signalling
Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature · doi:10.1038/380627a0 · Cited by 1,557 · see citing works
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553 · see citing works
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
Peschon, J. J., Morrissey, P., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1955 · Cited by 1,553 · see citing works
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545 · cited 1× · see citing works
“The IL-4 receptor (IL-4R) is expressed on diverse cells including hematopoetic, endothelial, epithelial, muscle, fibroblast, hepatocyte, and brain cells [53]; the expression of IL-4R on these widely diverse cells reflects the pleiotropic effects of IL-4.”
BackgroundSellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483 · see citing works
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C. M., Baetscher, M., Schneider, P., Tschopp, J., & Browning, J. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1697 · Cited by 1,479 · see citing works
B lymphocytes: how they develop and function
LeBien, T. W., & Tedder, T. F. (2008) · Blood · doi:10.1182/blood-2008-02-078071 · Cited by 1,400 · see citing works
Yanaba, K., Bouaziz, J., Haas, K. M., Poe, J. C., Fujimoto, M., & Tedder, T. F. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.017 · Cited by 1,239 · see citing works
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
Nutt, S. L., Heavey, B., Rolink, A. G., & Busslinger, M. (1999) · Nature · doi:10.1038/44076 · Cited by 1,179 · see citing works
Lam, K., Kühn, R., & Rajewsky, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80373-6 · Cited by 1,101 · see citing works
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.
Howard, M., Farrar, J., Hilfiker, M. L., Johnson, B., Takatsu, K., Hamaoka, T., & Paul, W. E. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.155.3.914 · Cited by 1,099 · see citing works
Intraclonal generation of antibody mutants in germinal centres
Jacob, J., Kelsoe, G. H., Rajewsky, K., & Weiss, U. K. (1991) · Nature · doi:10.1038/354389a0 · Cited by 1,092 · see citing works
Competence and competition: the challenge of becoming a long-lived plasma cell
Radbruch, A., Muehlinghaus, G., Luger, E., Inamine, A., Smith, K. G. C., Dörner, T., & Hiepe, F. (2006) · Nature reviews. Immunology · doi:10.1038/nri1886 · Cited by 1,033 · see citing works
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease
Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H., & Komori, T. (1989) · Blood · doi:10.1182/blood.v74.4.1360.1360 · Cited by 928 · see citing works
The Evolution of Adaptive Immune Systems
Cooper, M. D., & Alder, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.001 · Cited by 875 · see citing works
Reciprocal regulation of polarized cytokine production by effector B and T cells
Harris, D. P., Haynes, L., Sayles, P. C., et al. (2000) · Nature Immunology · doi:10.1038/82717 · Cited by 840 · see citing works
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.
Hayakawa, K., Hardy, R. R., Parks, D. R., & Herzenberg, L. A. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.1.202 · Cited by 814 · see citing works
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813 · see citing works
Stimulation of B-cell progenitors by cloned murine interleukin-7
Namen, A. E., Lupton, S. D., Hjerrild, K., Wignall, J. M., Mochizuki, D. Y., Schmierer, A. E., Mosley, B., March, C. J., Urdal, D. L., Gillis, S. A., et al. (1988) · Nature · doi:10.1038/333571a0 · Cited by 803 · see citing works
THE FUNCTIONS OF THE THYMUS SYSTEM AND THE BURSA SYSTEM IN THE CHICKEN
Cooper, M. D., Peterson, R. D. A., South, M. A., et al. (1966) · The Journal of Experimental Medicine · doi:10.1084/jem.123.1.75 · Cited by 794 · see citing works
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
Cerutti, A., Cols, M., & Puga, I. (2013) · Nature reviews. Immunology · doi:10.1038/nri3383 · Cited by 775 · see citing works
IFN- gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.
Finkelman, F. D., Katona, I. M., Mosmann, T. R., & Coffman, R. L. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.4.1022 · Cited by 724 · see citing works
Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., Nakajima, K., Pyun, K., & Kishimoto, T. (1985) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.82.16.5490 · Cited by 691 · see citing works
Duddy, M., Niino, M., Adatia, F., Hebert, S., Freedman, M., Atkins, H., Kim, H., & Bar-Or, A. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.10.6092 · Cited by 662 · see citing works
Interleukin-7 receptor expression: intelligent design
Mazzucchelli, R. I., & Durum, S. K. (2007) · Nature reviews. Immunology · doi:10.1038/nri2023 · Cited by 649 · see citing works
Haas, K. M., Poe, J. C., Steeber, D. A., & Tedder, T. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.011 · Cited by 628 · see citing works
A complete immunoglobulin gene is created by somatic recombination
Brack, C., Hirama, M., Lenhard-Schuller, R., & Tonegawa, S. (1978) · Cell · doi:10.1016/0092-8674(78)90078-8 · Cited by 623 · see citing works
Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis1
Evans, J., Chavez-Rueda, K., Eddaoudi, A., Meyer-Bahlburg, A., Rawlings, D., Ehrenstein, M., & Mauri, C. (2007) · Journal of Immunology · doi:10.4049/jimmunol.178.12.7868 · Cited by 591 · see citing works
The follicular versus marginal zone B lymphocyte cell fate decision
Pillai, S. S., & Cariappa, A. (2009) · Nature reviews. Immunology · doi:10.1038/nri2656 · Cited by 571 · see citing works
Cytokine-producing B lymphocytes-key regulators of immunity
Lund, F. E. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.003 · Cited by 556 · see citing works
Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions
Corinti, S., Albanesi, C., la Sala, A., Pastore, S., & Girolomoni, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4312 · Cited by 555 · see citing works
Information networks in the mammary gland
Hennighausen, L. G., & Robinson, G. W. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1714 · Cited by 506 · see citing works
Evolution of the AID/APOBEC Family of Polynucleotide (Deoxy)cytidine Deaminases
Conticello, S. G., Thomas, C. J. F., Petersen‐Mahrt, S. K., & Neuberger, M. S. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msi026 · Cited by 489 · see citing works
Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 482 · see citing works
Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production
Rosser, E. C., Oļeiņika, K., Tonon, S., Doyle, R., Bosma, A., Carter, N. A., Harris, K., Jones, S. A., Klein, N. J., & Mauri, C. (2014) · Nature Medicine · doi:10.1038/nm.3680 · Cited by 452 · see citing works
Steinke, J. W., & Borish, L. (2001) · Respiratory Research · doi:10.1186/rr40 · Cited by 445 · see citing works
Samoilova, E. B., Horton, J. L., Hilliard, B. A., Liu, T.-S. T., & Chen, Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6480 · Cited by 441 · see citing works
Idzerda, R. L., March, C. J., Mosley, B., Lyman, S. D., Bos, T. V., Gimpel, S. D., Din, W. S., Grabstein, K. H., Widmer, M. B., & Park, L. S. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.861 · Cited by 420 · see citing works
B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity
Alugupalli, K. R., Leong, J. M., Woodland, R. T., Muramatsu, M., Honjo, T., & Gerstein, R. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.019 · Cited by 411 · see citing works
Distinct Profiles of Human B Cell Effector Cytokines: A Role in Immune Regulation?1
Duddy, M., Alter, A., & Bar-Or, A. (2004) · Journal of Immunology · doi:10.4049/jimmunol.172.6.3422 · Cited by 393 · see citing works
van de Veerdonk, F. L., Stoeckman, A. K., Wu, G., Boeckermann, A. N., Azam, T., Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Hao, R., Kalabokis, V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121534109 · Cited by 383 · see citing works
Namen, A. E., Schmierer, A. E., March, C. J., et al. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.988 · Cited by 369 · see citing works
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker, C., Thompson, D., Matsumoto, A., Nebert, D. W., & Vasiliou, V. (2010) · Human Genomics · doi:10.1186/1479-7364-5-1-30 · Cited by 368 · see citing works
IL-37: a new anti-inflammatory cytokine of the IL-1 family
Boraschi, D., Lucchesi, D., Hainzl, S., Leitner, M., Maier, E., Mangelberger, D., Oostingh, G. J., Pfaller, T., Pixner, C., Posselt, G., et al. (2011) · European Cytokine Network · doi:10.1684/ecn.2011.0288 · Cited by 360 · see citing works
Kunkel, E. J., Kim, C. H., Lazarus, N. H., Vierra, M. A., Soler, D. F., Bowman, E. P., & Butcher, E. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17244 · Cited by 348 · see citing works
Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.
Grabstein, K. H., Waldschmidt, T. J., Finkelman, F. D., et al. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.1.257 · Cited by 346 · see citing works
A direct role for IFN-γ in regulation of Th1 cell development
Bradley, L. M., Dalton, D. K., & Croft, M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1350 · Cited by 322 · see citing works
Pan, J., Kunkel, E. J., Gosslar, U., Lazarus, N. H., Langdon, P., Broadwell, K., Vierra, M. A., Genovese, M. C., Butcher, E. C., & Soler, D. F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.2943 · Cited by 321 · see citing works
Therapeutic B cell depletion impairs adaptive and autoreactive CD4 + T cell activation in mice
Bouaziz, J., Yanaba, K., Venturi, G. M., Wang, Y., Tisch, R., Poe, J. C., & Tedder, T. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709205105 · Cited by 315 · see citing works
Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2)
Wang, W., Soto, H., Oldham, E. R., Buchanan, M. E., Homey, B., Catron, D., Jenkins, N. A., Copeland, N. G., Gilbert, D. J., Nguyen, N. T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001461200 · Cited by 294 · see citing works
Self-citationVella, A. T., Teague, T. K., Ihle, J. N., Kappler, J. W., & Marrack, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.2.325 · Cited by 289 · see citing works
Goodwin, R. G., Lupton, S. D., Schmierer, A. E., Hjerrild, K., Jerzy, R., Clevenger, W., Gillis, S. A., Cosman, D. J., & Namen, A. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.302 · Cited by 287 · see citing works
V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes
Han, S., Dillon, S. R., Zheng, B. Q., et al. (1997) · Science · doi:10.1126/science.278.5336.301 · Cited by 283 · see citing works
IFN‐α/β enhances BCR‐dependent B cell responses
Braun, D., Caramalho, Í., & Demengeot, J. (2002) · International Immunology · doi:10.1093/intimm/14.4.411 · Cited by 269 · see citing works
Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator
Hevér, A., Roth, R. B., Hevezi, P. A., Marin, M. E., Acosta, J. A., Acosta, H., Rojas, J., Herrera, R. M. B., Grigoriadis, D. E., White, E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703451104 · Cited by 254 · see citing works
Self-citationPope, S. M., Zimmermann, N., Stringer, K. F., Karow, M. L., & Rothenberg, M. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5341 · Cited by 250 · see citing works
Hardy, R. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2749 · Cited by 249 · see citing works
V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses
Papavasiliou, F. N., Casellas, R. C., Suh, H., et al. (1997) · Science · doi:10.1126/science.278.5336.298 · Cited by 246 · see citing works
Okuda, Y., Sakoda, S., Bernard, C. C. A., Fujimura, H., Saeki, Y., Kishimoto, T., & Yanagihara, T. (1998) · International Immunology · doi:10.1093/intimm/10.5.703 · Cited by 244 · see citing works
Kawano, Y., Noma, T., & Yata, J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.11.4948 · Cited by 233 · see citing works
Beurel, E., & Jope, R. S. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-9 · Cited by 230 · see citing works
Wilson, E., & Butcher, E. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041069 · Cited by 229 · see citing works
Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.
Illera, V. A., Perandones, C. E., Stunz, L. L., Mower, D. A., & Ashman, R. F. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.6.2965 · Cited by 210 · see citing works
Corcoran, A. E., Smart, F. M., Cowling, R. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00543.x · Cited by 204 · see citing works
Scala, G., Kuang, Y.-D., Hall, R. E., et al. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.6.1637 · Cited by 186 · see citing works
Nakayama, T., Hieshima, K., Nagakubo, D., Sato, E., Nakayama, M., Kawa, K., & Yoshie, O. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1665-1674.2004 · Cited by 184 · see citing works
Maseda, D., Smith, S. H., DiLillo, D. J., Bryant, J. M., Candando, K. M., Weaver, C. T., & Tedder, T. F. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102500 · Cited by 174 · see citing works
Bao, Y., & Cao, X.-T. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.04.001 · Cited by 161 · see citing works
Matsukura, S., Kokubu, F., Noda, H., Tokunaga, H., & Adachi, M. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)80195-3 · Cited by 160 · see citing works
Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential
Dorshkind, K. A., & Montecino‐Rodriguez, E. (2007) · Nature reviews. Immunology · doi:10.1038/nri2019 · Cited by 159 · see citing works
METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages
Ushach, I., Burkhardt, A. M., Martinez, C., Hevezi, P. A., Gerber, P. A., Buhren, B. A., Schrumpf, H., Valle‐Rios, R., Vazquez, M. I., Homey, B., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.11.006 · Cited by 155 · see citing works
Self-citationWurster, A. L., Rodgers, V. L., White, M. F., Rothstein, T. L., & Grusby, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201207200 · Cited by 150 · see citing works
Maseda, D., Candando, K. M., Smith, S. H., Kalampokis, I., Weaver, C. T., Plevy, S. E., Poe, J. C., & Tedder, T. F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300649 · Cited by 144 · cited 2× · see citing works
“These data are reminiscent of animal studies where Breg cells have been shown to lead to the resolution of colitis in mice [88].”
BackgroundResultInduction of oral tolerance to cellular immune responses in the absence of Peyer's patches
Spahn, T. W., Fontana, A., Faria, A. M. C., Slavin, A., Eugster, H., Zhang, X., Koni, P. A., Ruddle, N. H., Flavell, R. A., Rennert, P. D., et al. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200104)31:4 · Cited by 143 · see citing works
Activation of Marginal Zone B Cells from Lupus Mice with Type A(D) CpG-Oligodeoxynucleotides
Brummel, R., & Lenert, P. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2429 · Cited by 142 · see citing works
Yang, X., & Brunham, R. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.3.1439 · Cited by 138 · see citing works
Production of interleukin 1 activity by normal human peripheral blood B lymphocytes.
Matsushima, K., Procopio, A. D., Abe, H., Scala, G., Ortaldo, J. R., & Oppenheim, J. J. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.1132 · Cited by 137 · see citing works
Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
Lu, B., Ebensperger, C., Dembić, Z., Wang, Y., Kvatyuk, M., Lu, T., Coffman, R. L., Pestka, S., & Rothman, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8233 · Cited by 132 · see citing works
Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation
Cantin, E. M., Tanamachi, B., & Openshaw, H. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.3418-3423.1999 · Cited by 128 · see citing works
Interleukin 4/B cell stimulatory factor 1: one lymphokine, many functions 1
Paul, W. E. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.6.3315808 · Cited by 125 · see citing works
An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-Secreting Cell Accumulation
Morteau, O., Gerard, C. J., Lu, B., Ghiran, S., Rits, M., Fujiwara, Y., Law, Y., Distelhorst, K., Nielsen, E. M., Hill, E. D., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6309 · Cited by 117 · see citing works
An update on interleukin-4 and its receptor.
Chomarat, P., & Banchereau, J. (1997) · PubMed · Cited by 113 · see citing works
AUTOANTIBODIES IN HUMAN GLOMERULONEPHRITIS 1
Lange, K., Gold, M. M. A., Weiner, D., et al. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102052 · Cited by 101 · see citing works
GONNELLA, P. A., Waldner, H. P., & Weiner, H. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4456 · Cited by 97 · see citing works
Requirements for the Induction of Interleukin-6 by Herpes Simplex Virus-Infected Leukocytes
Paludan, S. (2001) · Journal of Virology · doi:10.1128/jvi.75.17.8008-8015.2001 · Cited by 96 · see citing works
Giroux, M., Schmidt, M., & Descoteaux, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4187 · Cited by 95 · see citing works
Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus.
Tanaka, Y., Saito, K., Shirakawa, F., et al. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.9.3043 · Cited by 91 · see citing works
Hanamoto, H., Nakayama, T., Miyazato, H., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63187-2 · Cited by 89 · see citing works
Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas
Suda, T., O’Garra, A., MacNeil, I. A., et al. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90200-b · Cited by 88 · see citing works
Spencer, N. D. (1997) · International Immunology · doi:10.1093/intimm/9.5.745 · Cited by 87 · see citing works
Namikawa, R., MO, M., de Vries, J. E., & Roncarolo, M. (1996) · Blood · doi:10.1182/blood.v87.5.1881.1881 · Cited by 83 · see citing works
Dinarello, C. A., & Jw, M. (1986) · Annual Review of Medicine · doi:10.1146/annurev.me.37.020186.001133 · Cited by 81 · see citing works
Thymic stromal lymphopoietin induces early human B‐cell proliferation and differentiation
Scheeren, F. A., van Lent, A. U., Nagasawa, M., Weijer, K. C., Spits, H., Legrand, N., & Blom, B. (2010) · European Journal of Immunology · doi:10.1002/eji.200939419 · Cited by 78 · see citing works
Interleukin 4: Signalling Mechanisms and Control of T Cell Differentiation
Paul, W. E. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515280.ch14 · Cited by 75 · see citing works
Hikida, M., Nakayama, Y., Yamashita, Y., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.365 · Cited by 73 · see citing works
Wei, C., Zeff, R. A., & Goldschneider, I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1961 · Cited by 68 · see citing works
Epstein-Barr virus transformed B lymphocytes produce interleukin-5
Paul, C., Keller, J. R., Armpriester, J., et al. (1990) · Blood · doi:10.1182/blood.v75.7.1400.1400 · Cited by 62 · see citing works
B cells participate in tolerance and autoimmunity through cytokine production
Luu, V. P., Vazquez, M. I., & Zlotnik, A. (2013) · Autoimmunity · doi:10.3109/08916934.2013.856006 · Cited by 60 · see citing works
Self-citationInterleukin newcomers creating new numbers in rheumatology: IL-34 to IL-38
Clavel, G., Thiolat, A., & Boissier, M. (2013) · Joint Bone Spine · doi:10.1016/j.jbspin.2013.04.014 · Cited by 60 · see citing works
Isler, P., Rochemonteix, B. G.-D., Songeon, F., et al. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.2.3313 · Cited by 55 · see citing works
Takegawa, S., Jin, Z. H., Nakayama, T., Oyama, T., Hieshima, K., Nagakubo, D., Shirakawa, A., Tsuzuki, T., Nakamura, S., & Yoshie, O. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00687.x · Cited by 51 · see citing works
Abed, N. S., Chace, J. H., Fleming, A. L., et al. (1994) · Cellular Immunology · doi:10.1006/cimm.1994.1034 · Cited by 46 · see citing works
Gujer, C., Sandgren, K. J., Douagi, I., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810460 · Cited by 46 · see citing works
Eggesbø, J. B., Hjermann, I., Høstmark, A. T., & Kierulf, P. (1996) · Cytokine · doi:10.1006/cyto.1996.0022 · Cited by 43 · see citing works
Differential Regulation of CCL22 Gene Expression in Murine Dendritic Cells and B Cells
Ghadially, H., Ross, X.-L., Kerst, C., Dong, J., Reske‐Kunz, A. B., & Ross, R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5620 · Cited by 37 · see citing works
Baumgarth, N., Jager, G. C., Herman, O. C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4766 · Cited by 37 · see citing works
IL-4-stimulated NF-κB activity is required for Stat6 DNA binding
Thieu, V. T., Nguyen, E., McCarthy, B. P., Bruns, H. A., Kapur, R., Chang, C., & Kaplan, M. H. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1106707 · Cited by 29 · see citing works
IL-17A Induces CCL28, Supporting the Chemotaxis of IgE-Secreting B Cells
Scanlon, K. M., Hawksworth, R. J., Lane, S. J., & Mahon, B. P. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000322178 · Cited by 26 · see citing works
Johnson‐Léger, C., Hasbold, J., Holman, M. J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1150 · Cited by 25 · see citing works
B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment
Hashimoto, Y. K., Montecino‐Rodriguez, E., Leathers, H., Stephan, R. P., & Dorshkind, K. A. (2002) · Blood · doi:10.1182/blood-2002-03-0733 · Cited by 21 · see citing works
Demengeot, J. (1997) · International Immunology · doi:10.1093/intimm/9.11.1677 · Cited by 21 · see citing works
Absence of salivary CCL28 in primary Sjögren’s syndrome
Hernández‐Molina, G., Burkhardt, A. M., Lima, G., Zlotnik, A., Betanzos, J. L., Bahena, S., & Llorente, L. (2015) · Rheumatology International · doi:10.1007/s00296-014-3210-0 · Cited by 17 · see citing works
Self-citationTargeting B cells and autoantibodies in the therapy of autoimmune diseases
Kao, D., Lux, A., Schwab, I., & Nimmerjahn, F. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0427-7 · Cited by 14 · see citing works
LIU, G.-X., Lan, J. Q., Sun, Y., et al. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.544 · Cited by 14 · see citing works
The functions of the thymus system and the bursa system in the chicken. 1966.
Cooper, M. D., Peterson, R. D. A., South, M. A., et al. (2006) · PubMed · Cited by 10 · see citing works
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2
Eugster (1998) · Pure Amsterdam UMC · doi:10.1002/(sici)1521-4141(199807)28:07 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [56]Rush JS Hodgkin PD B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation European journal of immunology 2001 31 1150 9 11298340
- [74]Eugster HP Frei K Kopf M Lassmann H Fontana A IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis European journal of immunology 1998 28 2178 87 9692887
Cited by
Sorted by citations
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352 · see citing works
TH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
Staley, M., Conners, M. G., Hall, K., & Miller, L. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.04.011 · Cited by 100 · see citing works
Immunological Responses to Envenomation
Ryan, R. Y. M., Seymour, J., Loukas, A., Lopez, J. A., Ikonomopoulou, M. P., & Miles, J. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661082 · Cited by 49 · see citing works
Cytokine‐Producing B Cells Promote Immune‐Mediated Bile Duct Injury in Murine Biliary Atresia
Bednarek, J., Traxinger, B., Brigham, D., Roach, J., Orlicky, D., Wang, D., Pelanda, R., & Mack, C. L. (2018) · Hepatology · doi:10.1002/hep.30051 · Cited by 38 · see citing works
Lecompte, S., Abou-Samra, M., Boursereau, R., Noel, L., & Brichard, S. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2465-5 · Cited by 34 · see citing works
Jung, S., Singh, K., & del Sol, A. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa283 · Cited by 9 · see citing works
- Authors
- Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Zlotnik, Albert
- ORCID
- Zlotnik, Albert
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 74
- Issue
- 2
- Pages
- 318-326
- ISSN
- 1043-4666 (ISSN-L)
- PMC
- PMC4475485
- OpenAlex
- W2000119111
- Cited by
- 421
- References
- 131
- Citations by year
- 2026: 26 · 2025: 52 · 2024: 58 · 2023: 49 · 2022: 59 · 2021: 70 · 2020: 32 · 2019: 24 · 2018: 13 · 2017: 18 · 2016: 11 · 2015: 8 · 2013: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIAID NIH (R01 AI93548 and R21 AI096278)
- NSF-GK-12 (DGE-0638751)
- NIH MBRS-IMSD (GM055246)
- CONACYT/SEP (#329416/BC-1455)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, cytokine production, immune microenvironment, B cell differentiation, B cell activation, interleukins, interferon, chemokines, CCL28, mucosal immunity, antibody production
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Humans, Lymphocyte Activation, Cytokines, Cellular Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
