The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ontogeny-related changes in proliferative potential of human hematopoietic cells.
Open accessAbstract
Blood cells originate from hematopoietic stem cells that are located at different sites during ontogeny. Production of human stem cells and their progeny in culture is expected to have important implications for experimental therapeutic strategies involving gene transfer and transplantation. Here we report striking differences between primitive hematopoietic cells purified from adult bone marrow, umbilical cord blood, and fetal liver in cytokine-supplemented, serum-free cultures. In such cultures both the fraction of responding cells and their ability to produce CD34+ progenitor cells decreased markedly with the age of the cell donor. These results document extensive, ontogeny-related functional differences between primitive hematopoietic cells.
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Citations
Cites
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Cited by
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
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Self-citationHuman bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
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Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
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Self-citationTelomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow
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Metadata
- Authors
- Lansdorp, P. M., Dragowska, W., & Mayani, H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-09-01
- Volume
- 178
- Issue
- 3
- Pages
- 787-791
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2059626630
- Cited by
- 391
- References
- 3
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
