Stems Cells and the Pathways to Aging and Cancer
Open accessAbstract
The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis.
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Environmental stress may damage cellular constituents including DNA, which has been proposed to underlie ageing and limit lifespan.
“Environmental stress may lead to damage of cellular constituents, including DNA, a process that has been proposed to underlie the ageing of cells and tissue and to limit lifespan104,105.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [105]
In mouse HSCs and neural stem cells, excessive cellular ROS concentrations cause abnormal proliferation, malignancy, and compromised self-renewal.
“in HSCs and neural stem cells (NSCs) of mice, excessive cellular ROS concentrations lead to abnormal proliferation, malignancy and compromised stem cell self-renewal11–14”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [13]
DDR pathways that safeguard genomic integrity may show reduced activity in stem cells with age.
“These observations suggest that DDR pathways, evolved to safeguard genomic integrity and maximize survival of the organism13,44–46, may show reduced activity in stem cells with age.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [13]
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- Authors
- Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L.
- Affiliations
- Harvard University (US)
- University of California San Diego (US)
- Stanford Medicine (US)
- Corresponding author
- Rossi, Derrick J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 132
- Issue
- 4
- Pages
- 681-696
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157285575
- Cited by
- 895
- References
- 48
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 25 · 2023: 45 · 2022: 28 · 2021: 38 · 2020: 41 · 2019: 38 · 2018: 45 · 2017: 51 · 2016: 63 · 2015: 53 · 2014: 60 · 2013: 70 · 2012: 66
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- stem cell aging, adult stem cells, progenitor cells, stem cell dysfunction, tissue aging, organ function decline, cancer
- MeSH terms
- Aged, Aging, Animals, Humans, Neoplasms, Stem Cells, Signal Transduction, Cellular Senescence
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