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Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.
Open accessAbstract
MRL-lpr mice develop aggressive autoimmune kidney disease associated with increased or de novo renal expression of major histocompatibility complex (MHC) class II molecules and a massive systemic expansion of CD4-CD- double negative (DN) T cells. Whereas non-MHC linked genes can have a profound effect on the development of nephritis, lymphadenopathy, and anti-DNA antibody production in MRL-lpr mice, the role of MHC molecules has not been unequivocally established. To study the role of MHC class II in this murine model of systemic lupus erythematosis, class II-deficient MRL-lpr mice (MRL-lpr -/-) were created. MRL-lpr -/- mice developed lymphadenopathy but not autoimmune renal disease or autoantibodies. This study demonstrates that class II expression is critical for the development of autoaggressive CD4+ T cells involved in autoimmune nephritis and clearly dissociates DN T cell expansion from autoimmune disease initiation.
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Cited by
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells
Rathmell, J. C., Cooke, M. P., Ho, W. Y., Grein, J., Townsend, S. E., Davis, M. M., & Goodnow, C. C. (1995) · Nature · doi:10.1038/376181a0 · Cited by 469
Kansal, R., Richardson, N., Neeli, I., Khawaja, S., Chamberlain, D., Ghani, M., Ghani, Q.-U.-A., Balazs, L., Beranova-Giorgianni, S., Giorgianni, F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav1648 · Cited by 382
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Barber, D. F., Bartolomé, A., Hernandez, C., Flores, J. M., Redondo, C., Fernandez-Arias, C., Camps, M., Rückle, T., Schwarz, M. K., Rodríguez, S., et al. (2005) · Nature Medicine · doi:10.1038/nm1291 · Cited by 310
Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
Tilstra, J. S., Avery, L., Menk, A. V., Gordon, R. A., Smita, S., Kane, L. P., Chikina, M., Delgoffe, G. M., & Shlomchik, M. J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120859 · Cited by 149
Metadata
- Authors
- Jevnikar, A. M., Grusby, M. J., & Glimcher, L. H.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1994-04-01
- Volume
- 179
- Issue
- 4
- Pages
- 1137-1143
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2136748251
- Cited by
- 188
- References
- 0
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. https://app.cochat.ai/papers/10.1084/jem.179.4.1137
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- Jevnikar, A. M., Grusby, M. J., & Glimcher, L. H. (1994). Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. The Journal of experimental medicine. https://doi.org/10.1084/jem.179.4.1137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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