The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.
Open accessAbstract
Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histocompatibility complex class I-presented peptide antigen pulsed onto dendritic APCs induces protective immunity to lethal challenge by a tumor transfected with the antigen gene. The immunity is antigen specific, requiring expression of the antigen gene by the tumor target, and is eliminated by in vivo depletion of CD8+ T cells. Furthermore, mice that have rejected the transfected tumor are protected from subsequent challenge with the untransfected parent tumor. These results suggest that immunization strategies using antigen-pulsed DC may be useful for inducing tumor-specific immune responses.
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Cites
Rosenberg, S. A., Packard, B. S., Aebersold, P. M., Solomon, D., Topalian, S. L., Toy, S. T., Simon, P., Lotze, M. T., Yang, J. C., Seipp, C. A., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812223192527 · Cited by 2,389
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Cited by
Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells
Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G., & Schadendorf, D. (1998) · Nature Medicine · doi:10.1038/nm0398-328 · Cited by 2,862
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.
Boczkowski, D., Nair, S. K., Snyder, D., & Gilboa, E. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.465 · Cited by 915
DNA–based immunization by in vivo transfection of dendritic cells
Condon, C., Watkins, S. C., Celluzzi, C. M., Thompson, K., & Falo, L. D. (1996) · Nature Medicine · doi:10.1038/nm1096-1122 · Cited by 819
Self-citationChen, H., Hou, J., Jiang, X., Ma, S., Meng, M., Wang, B., Zhang, M., Zhang, M., Tang, X., Zhang, F., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.591 · Cited by 75
Metadata
- Authors
- Celluzzi, C. M., Mayordomo, J. I., Storkus, W. J., Lotze, M. T., & Falo, L. D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-01-01
- Volume
- 183
- Issue
- 1
- Pages
- 283-287
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2138913424
- Cited by
- 717
- References
- 1
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. https://app.cochat.ai/papers/10.1084/jem.183.1.283
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- Celluzzi, C. M., Mayordomo, J. I., Storkus, W. J., Lotze, M. T., & Falo, L. D. (1996). Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.1.283
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