The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
Open accessAbstract
The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA-1-deficient mice did not reject immunogenic tumors grafted into footpads and did not demonstrate priming response against tumor-specific antigen. Thus CD11a deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal.
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Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Cited by
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Syk is required for integrin signaling in neutrophils
Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V. L., & Lowell, C. A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00303-5 · Cited by 421
Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo
Halle, S., Halle, O., & Förster, R. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.04.002 · Cited by 302
Hepatic platelet and leukocyte adherence during endotoxemia
Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M.-M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275
Li, C., Li, W., Xiao, J., Jiao, S., Teng, F., Xue, S., Zhang, C., Sheng, C., Leng, Q., Rudd, C. E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404578 · Cited by 60
Metadata
- Authors
- Schmits, R., Kündig, T. M., Baker, D. M., Shumaker, G., Simard, J. J., Duncan, G., Wakeham, A., Shahinian, A., van der Heiden, A., Bachmann, M. F., Ohashi, P. S., Mak, T. W., & Hickstein, D. D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-04-01
- Volume
- 183
- Issue
- 4
- Pages
- 1415-1426
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2159180573
- Cited by
- 273
- References
- 1
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. https://app.cochat.ai/papers/10.1084/jem.183.4.1415
- The paper
- Schmits, R., Kündig, T. M., Baker, D. M., Shumaker, G., Simard, J. J., Duncan, G., Wakeham, A., Shahinian, A., van der Heiden, A., Bachmann, M. F., Ohashi, P. S., Mak, T. W., & Hickstein, D. D. (1996). LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.4.1415
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
