The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.
Open accessAbstract
Nitric oxide (NO)-related activity has been shown to be protective against Plasmodium falciparum in vitro. It has been hypothesized, however, that excess NO production contributes to the pathogenesis of cerebral malaria. The purpose of this study was to compare markers of NO production [urinary and plasma nitrate + nitrite (NOx)], leukocyte-inducible nitric oxide synthase type 2 (NOS2), and plasma TNF-alpha and IL-10 levels with disease severity in 191 Tanzanian children with and without malaria. Urine NOx excretion and plasma NOx levels (corrected for renal impairment) were inversely related to disease severity, with levels highest in subclinical infection and lowest in fatal cerebral malaria. Results could not be explained by differences in dietary nitrate ingestion among the groups. Plasma levels of IL-10, a cytokine known to suppress NO synthesis, increased with disease severity. Leukocyte NOS2 antigen was detectable in all control children tested and in all those with subclinical infection, but was undetectable in all but one subject with cerebral malaria. This suppression of NO synthesis in cerebral malaria may contribute to pathogenesis. In contrast, high fasting NOx levels and leukocyte NOS2 in healthy controls and asymptomatic infection suggest that increased NO synthesis might protect against clinical disease. NO appears to have a protective rather than pathological role in African children with malaria.
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Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,366
Ding, A. H., Nathan, C. F., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,826
De Caterina, R., Libby, P., Peng, H. B., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,782
Macrophage deactivation by interleukin 10.
Bogdan, C., Vodovotz, Y., & Nathan, C. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.6.1549 · Cited by 1,238
Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
McGuire, W., Hill, A. V. S., Allsopp, C. E. M., Greenwood, B. M., & Kwiatkowski, D. (1994) · Nature · doi:10.1038/371508a0 · Cited by 1,169
Kwiatkowski, D., Sambou, I., Twumasi, P., Greenwood, B. M., Hill, A. V. S., Manogue, K. R., Cerami, A., Castracane, J., & Brewster, D. R. (1990) · The Lancet · doi:10.1016/0140-6736(90)92827-5 · Cited by 872
Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
Grau, G. E., Taylor, T. E., Molyneux, M. E., Wirima, J. J., Vassalli, P., Hommel, M., & Lambert, P.-H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906153202404 · Cited by 842
Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB
Peng, H.-B., Libby, P., & Liao, J. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.14214 · Cited by 710
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages
Gazzinelli, R. T., Oswald, I. P., James, S. L., & Sher, A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1792 · Cited by 694
(1989) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068338 · Cited by 693
Cited by
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Metabolic Reprograming in Macrophage Polarization
Galván-Peña, S., & O’Neill, L. A. J. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00420 · Cited by 944
Nitric oxide and redox mechanisms in the immune response
Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765
Inducible nitric oxide synthase in human diseases
Kröncke, K.-D., Fehsel, K., & Kolb-Bachofen, V (2001) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.1998.00648.x · Cited by 585
(2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12313_2 · Cited by 543
Metadata
- Authors
- Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., Arnelle, D. R., Hollis, D., McDonald, M. I., & Granger, D. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-08-01
- Volume
- 184
- Issue
- 2
- Pages
- 557-567
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2132575805
- Cited by
- 431
- References
- 51
- FWCI
- 35.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., Arnelle, D. R., Hollis, D., McDonald, M. I., & Granger, D. L. (1996). Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. The Journal of experimental medicine. https://doi.org/10.1084/jem.184.2.557
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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