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Cited by 400Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

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Wu, L, Li, C L, Shortman, K·1996·The Journal of experimental medicine
DOI 10.1084/jem.184.3.903PMC PMC2192802
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Abstract

Successive T-precursors isolated from adult mouse thymus were examined for their developmental potential, by transfer to irradiated Ly 5-disparate recipients. The earliest, "low CD4" precursors formed T, B, and dendritic cells (DC), but not myeloid cells, in accordance with earlier studies. Surprisingly, the next downstream CD4-8-3 44+25+ precursor population still formed DC as well as T cells although it no longer formed B or myeloid cells. Further down-stream, the CD4-8 3-44-25+ population formed only T cells. The thymic and splenic DC progeny of the early thymic precursors all expressed high levels of CD8 alpha, in contrast with normal splenic DC and the splenic DC progeny of bone marrow stem cells, which consisted of both CD8 and CD8+ DC. A common precursor of T cells and of a subclass of DC is proposed, with CD8 alpha as a marker of the lymphoid-related DC lineage.

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  • ETP and DN2 cells can generate myeloid cells if removed from the thymus, whereas pro-T cells past PU.1 expression (DN3 or later) do not make myeloid cells under these conditions.

    “Whereas ETP and DN2 cells can generate myeloid cells if removed from the thymus, pro-T cells that have differentiated past the stage of PU.1 expression in the thymus (i.e., from the DN2 stage to the DN3 stage or later) do not make myeloid cells under these conditions”

    From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [51]

    In ‘Development of Lymphoid and Myeloid Cells from Intrathymic Precursors’ (pp. 905–906), the authors report that after intravenous transfer, the early low-CD4 precursors produced no discrete myeloid population and the CD44+CD25+ pro-T precursors produced myeloid cells only at background levels. They also report that the later CD44−CD25+ pre-T population could not form myeloid cells. Thus the later-stage finding is supported, but the claimed myeloid capacity of the earlier cells under these conditions is contrary to the reported results; the copy does not establish a PU.1-defined boundary. (LLM, conf=0.88)

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Authors
Wu, L., Li, C. L., & Shortman, K.
Affiliations
Walter and Eliza Hall Institute of Medical Research (AU)
ORCID
Venue
The Journal of experimental medicine
Publisher
Rockefeller University Press
Published
1996-09-01
Volume
184
Issue
3
Pages
903-911
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.184.3.903
PMC
PMC2192802
OpenAlex
W2149939821
Cited by
400
References
29
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 8
FWCI
13.35
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion, cc-by)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
thymic dendritic cells, dendritic cell precursors, common lymphoid progenitors, B cell development, myeloid cell development, thymus, splenic dendritic cells, hematopoietic stem cells
MeSH terms
Animals, Antigens, Ly, Dendrites, Mice, Inbred C57BL, Phenotype, T-Lymphocytes, Thymus Gland, Mice

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