The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions
Open accessAbstract
The binding of immunoglobulin E (IgE) to high affinity IgE receptors (FcεRI) expressed on the surface of mast cells primes these cells to secrete, upon subsequent exposure to specific antigen, a panel of proinflammatory mediators, which includes cytokines that can also have immunoregulatory activities. This IgE- and antigen-specific mast cell activation and mediator production is thought to be critical to the pathogenesis of allergic disorders, such as anaphylaxis and asthma, and also contributes to host defense against parasites. We now report that exposure to IgE results in a striking (up to 32-fold) upregulation of surface expression of FcεRI on mouse mast cells in vitro or in vivo. Moreover, baseline levels of FcεRI expression on peritoneal mast cells from genetically IgE-deficient (IgE −/−) mice are dramatically reduced (by ∼83%) compared with those on cells from the corresponding normal mice. In vitro studies indicate that the IgE-dependent upregulation of mouse mast cell FcεRI expression has two components: an early cycloheximide-insensitive phase, followed by a later and more sustained component that is highly sensitive to inhibition by cycloheximide. In turn, IgE-dependent upregulation of FcεRI expression significantly enhances the ability of mouse mast cells to release serotonin, interleukin-6 (IL-6), and IL-4 in response to challenge with IgE and specific antigen. The demonstration that IgE-dependent enhancement of mast cell FcεRI expression permits mast cells to respond to antigen challenge with increased production of proinflammatory and immunoregulatory mediators provides new insights into both the pathogenesis of allergic diseases and the regulation of protective host responses to parasites.
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Cites
Generation and Analysis of Interleukin-4 Deficient Mice
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Self-citationMast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
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FcR γ chain deletion results in pleiotrophic effector cell defects
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IL-4 is required to generate and sustain in vivo IgE responses.
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Self-citationMonoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.
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Cited by
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
IgE and mast cells in allergic disease
Galli, S. J., & Tsai, M. (2012) · Nature Medicine · doi:10.1038/nm.2755 · Cited by 1,799
Self-citationMAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
Self-citationTHE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
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Self-citationYu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y., & Orkin, S. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020656 · Cited by 600
“5 E and F) for expression of c-kit and the high-affinity IgE receptor (Fc RI), a specific marker of mast cells (21).”
Background
Metadata
- Authors
- Yamaguchi, M., Lantz, C. S., Oettgen, H. C., Katona, I. M., Fleming, T., Miyajima, I., Kinet, J.-P., & Galli, S. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-02-17
- Volume
- 185
- Issue
- 4
- Pages
- 663-672
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2154196772
- Cited by
- 448
- References
- 38
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions. https://app.cochat.ai/papers/10.1084/jem.185.4.663
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- Yamaguchi, M., Lantz, C. S., Oettgen, H. C., Katona, I. M., Fleming, T., Miyajima, I., Kinet, J.-P., & Galli, S. J. (1997). IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.185.4.663
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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