The DOI matches its Crossref record.
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
Open accessAbstract
In response to IgE and specific multivalent antigen, mast cell lines (both growth factor-dependent and -independent) induce the transcription and/or secretion of a number of cytokines having a wide spectrum of activities. We have identified IL-1, IL-3, IL-5, IL-6, IFN-gamma, GM-CSF, JE, MIP1 alpha, MIP1 beta, and TCA3 RNA in at least two of four mast cell clones. The production of these products (except JE) is activation-associated and can be induced by IgE plus antigen. In selected instances cytokine expression can also be induced by activation with Con A or phorbol ester plus ionophore, albeit to levels less than those observed with IgE plus antigen. In addition, long-term mast cell clones and primary cultures of bone marrow-derived mast cells specifically release IL-1, IL-4, and/or IL-6 bioactivity after activation. These findings suggest that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors. The relationship of mast cells to cells of the T lymphocyte lineage is discussed.
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Citations
Cited by
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells
Kim, S.-H., Jun, C.-D., Suk, K., Choi, B.-J., Lim, H., Park, S., Lee, S. H., Shin, H.-Y., Kim, D.-K., & Shin, T.-Y. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj063 · Cited by 495
Yamaguchi, M., Lantz, C. S., Oettgen, H. C., Katona, I. M., Fleming, T., Miyajima, I., Kinet, J.-P., & Galli, S. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.663 · Cited by 448
Self-citationGordon, J. R., & Galli, S. J. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.1.103 · Cited by 363
Self-citationThe diverse potential effector and immunoregulatory roles of mast cells in allergic disease
Williams, C. M. M., & Galli, S. J. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106485 · Cited by 355
Self-citationAngiogenic factors stimulate mast-cell migration
Gruber, B., Marchese, M., & Kew, R. (1995) · Blood · doi:10.1182/blood.v86.7.2488.2488 · Cited by 275
Metadata
- Authors
- Burd, P. R., Rogers, H. W., Gordon, J. R., Martin, C. A., Jayaraman, S., Wilson, S. D., Dvorak, A. M., Galli, S. J., & Dorf, M. E.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1989-07-01
- Volume
- 170
- Issue
- 1
- Pages
- 245-257
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2146717075
- Cited by
- 539
- References
- 0
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. https://app.cochat.ai/papers/10.1084/jem.170.1.245
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- Burd, P. R., Rogers, H. W., Gordon, J. R., Martin, C. A., Jayaraman, S., Wilson, S. D., Dvorak, A. M., Galli, S. J., & Dorf, M. E. (1989). Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. The Journal of experimental medicine. https://doi.org/10.1084/jem.170.1.245
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