Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

Palmer, Larry D.; Weng, Nan-ping; Levine, Bruce L.; June, Carl H.; Lane, H. Clifford; Hodes, Richard J.

doi:10.1084/jem.185.7.1381

Cited by 129HIV Research and TreatmentTelomeres, Telomerase, and SenescenceHIV-related health complications and treatments

Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

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Palmer, Larry D., Weng, Nan-ping, Levine, Bruce L., June, Carl H., Lane, H. Clifford, Hodes, Richard J.·1997·The Journal of Experimental Medicine

DOI 10.1084/jem.185.7.1381PMC PMC2196247

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Abstract

To address the possible role of replicative senescence in human immunodeficiency virus (HIV) infection, telomere length, telomerase activity, and in vitro replicative capacity were assessed in peripheral blood T cells from HIV+ and HIV− donors. Genetic and age-specific effects on these parameters were controlled by studying HIV-discordant pairs of monozygotic twins. Telomere terminal restriction fragment (TRF) lengths from CD4+ T cells of HIV+ donors were significantly greater than those from HIV− twins. In contrast, telomere lengths in CD8+ T cells from HIV+ donors were shorter than in HIV− donors. The in vitro replicative capacity of CD4+ cells from HIV+ donors was equivalent to that of HIV− donors in response to stimulation through T cell receptor CD3 and CD28. Little or no telomerase activity was detected in freshly isolated CD4+ or CD8+ lymphocytes from HIV+ or HIV− donors, but was induced by in vitro stimulation of both HIV+ and HIV− donor cells. These results suggest that HIV infection is associated with alterations in the population dynamics of both CD4+ and CD8+ T cells, but fail to provide evidence for clonal exhaustion or replicative senescence as a mechanism underlying the decline in CD4+ T cells of HIV-infected donors.

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CD4+ T cell telomere lengths are not shorter in HIV patients compared to healthy individuals.
“Telomere lengths of CD8+ T cells are shorter in HIV patients compared to healthy individuals, but this observation was not found in CD4+ T cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Palmer et al, 1997
Certain hallmarks of cellular senescence are found in T cells from HIV patients.
“Interestingly, certain hallmarks of cellular senescence are also found in T cells from patients with HIV (Effros et al, 1996; Wolthers et al, 1996; Palmer et al, 1997; Nelson et al, 2012; Pereira Ribeiro et al, 2016).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Palmer et al, 1997
The shorter telomere lengths in CD8+ T cells in HIV patients are independent of antiretroviral therapy status.
“These finds were also independent on whether HIV patients were on antiretroviral therapy (Effros et al, 1996; Wolthers et al, 1996; Palmer et al, 1997).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Palmer et al, 1997
CD8+ T cell telomere lengths are shorter in HIV patients compared to healthy individuals.
“Telomere lengths of CD8+ T cells are shorter in HIV patients compared to healthy individuals, but this observation was not found in CD4+ T cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Palmer et al, 1997

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Authors: Palmer, L. D., Weng, N.-P., Levine, B. L., June, C. H., Lane, H. C., & Hodes, R. J.
Affiliations: National Institutes of Health (US)
ORCID: Weng, Nan-ping
Levine, Bruce L.
June, Carl H.
Lane, H. Clifford
Hodes, Richard J.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1997-04-07
Volume: 185
Issue: 7
Pages: 1381-1386
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.185.7.1381
PMC: PMC2196247
OpenAlex: W2114119969
Cited by: 129
References: 20
Citations by year: 2026: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 5.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Keywords: HIV infection, telomere length, telomerase activity, replicative senescence, CD4+ T cells, CD8+ T cells, terminal restriction fragments, CD4+ T cell decline
MeSH terms: Adult, Cells, Cultured, Humans, Lymphocyte Activation, Middle Aged, Twins, Monozygotic, CD4-Positive T-Lymphocytes, HIV Infections, T-Lymphocyte Subsets, Telomere, Cellular Senescence, CD8-Positive T-Lymphocytes, Telomerase

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Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

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