. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Effros, Rita B.; Fletcher, Courtney V.; Gebo, Kelly; Halter, Jeffrey B.; Hazzard, William R.; Horne, Frances McFarland; Huebner, Robin E.; Janoff, Edward N.; Justice, Amy C.; Kuritzkes, Daniel; Nayfield, Susan G.; Plaeger, Susan F.; Schmader, Kenneth E.; Ashworth, John R.; Campanelli, Christine; Clayton, Charles P.; Rada, Beth; Woolard, Nancy F.; High, Kevin P.

doi:10.1086/590150

Cited by 539HIV-related health complications and treatmentsHIV Research and TreatmentHIV/AIDS Research and Interventions

. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Open access

Effros, Rita B., Fletcher, Courtney V., Gebo, Kelly, Halter, Jeffrey B., Hazzard, William R., Horne, Frances McFarland, Huebner, Robin E., Janoff, Edward N. +11 more·2008·Clinical Infectious Diseases

DOI 10.1086/590150PMC PMC3130308

Open this paper in CoChat — free account

Abstract

Highly active antiretroviral treatment has resulted in dramatically increased life expectancy among patients with HIV infection who are now aging while receiving treatment and are at risk of developing chronic diseases associated with advanced age. Similarities between aging and the courses of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome suggest that HIV infection compresses the aging process, perhaps accelerating comorbidities and frailty. In a workshop organized by the Association of Specialty Professors, the Infectious Diseases Society of America, the HIV Medical Association, the National Institute on Aging, and the National Institute on Allergy and Infectious Diseases, researchers in infectious diseases, geriatrics, immunology, and gerontology met to review what is known about HIV infection and aging, to identify research gaps, and to suggest high priority topics for future research. Answers to the questions posed are likely to help prioritize and balance strategies to slow the progression of HIV infection, to address comorbidities and drug toxicity, and to enhance understanding about both HIV infection and aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1086/590150

Cites

178 of 178 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The cumulative burden of HIV-related complications reduces a person's ability to compensate and respond to many events, which collectively results in onset of frailty and other geriatric syndromes.
“The cumulative burden of these complications reduces a person’s ability to compensate and respond to many events, which collectively results in onset of frailty and other geriatric syndromes (15, 17, 48).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [15]
The mechanisms accounting for the excess risk of HANA conditions in long-term treated HIV-infected adults likely include persistent immune dysfunction/inflammation, treatment toxicity, co-infections such as CMV, HCV, and HBV, and traditional risk factors including use of alcohol, tobacco, and psychoactive drugs.
“The mechanisms accounting for this excess risk likely include persistent immune dysfunction/inflammation, treatment toxicity, co-infections such as CMV, HCV and hepatitis B virus (HBV) and traditional risk factors (including use of alcohol, tobacco, and psychoactive drugs) (15,47,48).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [15]
eGFR is an important component in multi-variate models of mortality and hospitalization in HIV-infected persons.
“However, eGFR can be readily obtained from standard blood chemistry panels and is an important component in multi-variate models of mortality and hospitalization in HIV-infected persons (15, 17, 48, 55).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [15]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907 · see citing works
Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance
Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581 · see citing works
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412 · see citing works
Self-citation
Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
Fick, D. M., Cooper, J. W., Wade, W. E., Waller, J. L., Maclean, J. R., & Beers, M. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.22.2716 · Cited by 2,389 · see citing works
Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency Syndrome
Lane, H. C., Masur, H., Edgar, L. C., Whalen, G., Rook, A. H., & Fauci, A. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308253090803 · Cited by 1,600 · see citing works
Phenotype of frailty: characterization in the women's health and aging studies
Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., & Fried, L. P. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.3.262 · Cited by 1,215 · see citing works
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,180 · see citing works
AGE CHANGES IN GLOMERULAR FILTRATION RATE, EFFECTIVE RENAL PLASMA FLOW, AND TUBULAR EXCRETORY CAPACITY IN ADULT MALES
Davies, D. F., & Shock, N. W. (1950) · Journal of Clinical Investigation · doi:10.1172/jci102286 · Cited by 1,139 · see citing works
Liver-Related Deaths in Persons Infected With the Human Immunodeficiency Virus
The Data Collection on Adverse Events of Anti-HIV Drugs Study Group* (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.15.1632 · Cited by 1,115 · see citing works
Cancer Screening in Elderly Patients: A Framework for Individualized Decision Making
Walter, L. C., & Covinsky, K. E. (2001) · JAMA · doi:10.1001/jama.285.21.2750 · Cited by 1,003 · see citing works
Vaccines for preventing pneumococcal infection in adults
Moberley, S. A., Holden, J., Tatham, D. P., & Andrews, R. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000422.pub3 · Cited by 970 · see citing works
Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>
Walston, J. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2333 · Cited by 940 · see citing works
Severe CD4<sup>+</sup>T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
Guadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11708-11717.2003 · Cited by 866 · see citing works
Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Brinkman, K., Smeitink, J. A. M., Romijn, J. A., & Reiss, P. (1999) · The Lancet · doi:10.1016/s0140-6736(99)06102-4 · Cited by 863 · see citing works
Antiretroviral Therapy and the Prevalence and Incidence of Diabetes Mellitus in the Multicenter AIDS Cohort Study
Brown, T. T. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.10.1179 · Cited by 850 · see citing works
Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome
Grünfeld, C., Pang, M., Doerrler, W. T., Shigenaga, J. K., Jensen, P., & Feingold, K. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.5.1373735 · Cited by 845 · see citing works
Associations of Subclinical Cardiovascular Disease With Frailty
Newman, A. B., Gottdiener, J. S., McBurnie, M. A., Hirsch, C. H., Kop, W. J., Tracy, R. P., Walston, J. D., & Fried, L. P. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m158 · Cited by 803 · see citing works
Herpes Zoster
Gnann, J. W., & Whitley, R. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp013211 · Cited by 781 · see citing works
The Impact of Comorbid Chronic Conditions on Diabetes Care
Piette, J. D., & Kerr, E. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-2078 · Cited by 727 · see citing works
Metabolic Abnormalities and Cardiovascular Disease Risk Factors in Adults with Human Immunodeficiency Virus Infection and Lipodystrophy
Hadigan, C. M., Meigs, J. B., Corcoran, C. P., Rietschel, P., Piecuch, S., Basgoz, N. O., Davis, B., Sax, P. E., Stanley, T. L., Wilson, P. W. F., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/317541 · Cited by 679 · see citing works
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641 · see citing works
Impact of HIV infection and HAART on serum lipids in men
Riddler, S. A. (2003) · JAMA · doi:10.1001/jama.289.22.2978 · Cited by 624 · see citing works
The Incidence of Herpes Zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430150071008 · Cited by 618 · see citing works
Effectiveness of Pneumococcal Polysaccharide Vaccine in Older Adults
Jackson, L. A., Neuzil, K. M., Yu, O., Benson, P., Barlow, W. E., Adams, A. L., Hanson, C. A., Mahoney, L. D., Shay, D. K., & Thompson, W. W. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022678 · Cited by 608 · see citing works
Atherogenic Dyslipidemia in HIV-Infected Individuals Treated With Protease Inhibitors
Périard, D., Telenti, A., Sudre, P., Cheseaux, J., Halfon, P., Reymond, M. J., Marcovina, S. M., Glauser, M. P., NICOD, P. H., Darioli, R., et al. (1999) · Circulation · doi:10.1161/01.cir.100.7.700 · Cited by 603 · see citing works
Guidelines for the Management of Chronic Kidney Disease in HIV-Infected Patients: Recommendations of the HIV Medicine Association of the Infectious Diseases Society of America
Gupta, S. K., Eustace, J. A., Winston, J. A., Boydstun, I. I., Ahuja, T. S., Rodriguez, R. A., Tashima, K. T., Roland, M. E., Franceschini, N., Palella, F. J., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/430257 · Cited by 577 · see citing works
What does epidemiology tell us about risk factors for herpes zoster?
Thomas, S. L., & Hall, A. J. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00857-0 · Cited by 561 · see citing works
Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
Saurwein-Teissl, M., Lung, T. L., Marx, F., Gschösser, C., Asch, E., Blasko, I., Parson, W., Böck, G., Schönitzer, D., Trannoy, E., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5893 · Cited by 499 · see citing works
Varicella and Herpes Zoster
Weller, T. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312013092205 · Cited by 493 · see citing works
Age-related changes in liver structure and function: Implications for disease ?
Schmucker, D. L. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.06.009 · Cited by 481 · see citing works
Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study
Martínez, E., Mocroft, A., García-Viejo, M. A., Pérez-Cuevas, J. B., Blanco, J. L., Mallolas, J., Bianchi, L., Conget, I., Blanch, J., Phillips, A. N., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04056-3 · Cited by 456 · see citing works
Increase inClostridium difficile–related Mortality Rates, United States, 1999–2004
Redelings, M. D., Sorvillo, F. J., & Mascola, L. (2007) · Emerging infectious diseases · doi:10.3201/eid1309.061116 · Cited by 431 · see citing works
. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.
Desquilbet, L., Jacobson, L. P., Fried, L. P., Phair, J. P., Jamieson, B. D., Holloway, M., Margolick, J. B., & Study, F. T. M. A. C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.11.1279 · Cited by 420 · see citing works
Clinical Outcome of Patients with HIV-1 Infection according to Immunologic and Virologic Response after 6 Months of Highly Active Antiretroviral Therapy
Grabar, S., Moing, V. L., Goujard, C., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00007 · Cited by 417 · see citing works
An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
Goronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402 · see citing works
Vaccines for preventing pneumococcal infection in adults
Moberley, S. A., Holden, J., Tatham, D. P., & Andrews, R. M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000422.pub2 · Cited by 387 · see citing works
Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects
Purnell, J. Q., Zambon, A., Knopp, R. H., Pizzuti, D. J., Achari, R., Leonard, J. M., Locke, C. S., & Brunzell, J. D. (2000) · AIDS · doi:10.1097/00002030-200001070-00006 · Cited by 384 · see citing works
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · see citing works
Generation of Functional Thymocytes in the Human Adult
Jamieson, B. D., Douek, D. C., Killian, S., Hultin, L. E., Scripture-Adams, D. D., Giorgi, J. V., Marelli, D., Koup, R. A., & Zack, J. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80056-4 · Cited by 367 · see citing works
The Relationship Between Methamphetamine and Popper Use and Risk of HIV Seroconversion in the Multicenter AIDS Cohort Study
Plankey, M. W., Ostrow, D. G., Stall, R. D., Cox, C., Li, X., Peck, J. A., & Jacobson, L. P. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3180417c99 · Cited by 357 · see citing works
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years
Nelson, M. R., Katlama, C., Montaner, J. S., Cooper, D. A., Gazzard, B., Clotet, B., Lazzarin, A., Schewe, K., Lange, J. M. A., Wyatt, C. M., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3280b07b33 · Cited by 349 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Self-citation
Do Patterns of Comorbidity Vary by HIV Status, Age, and HIV Severity?
Goulet, J. L., Fultz, S. L., Rimland, D., Butt, A. A., Gibert, C. L., Rodriguez‐Barradas, M. C., BRYANT, K. J., & Justice, A. C. (2007) · Clinical Infectious Diseases · doi:10.1086/523577 · Cited by 329 · see citing works
Self-citation
Fat Distribution in Men With HIV Infection
(FRAM), F. T. S. O. F. R. A. M. C. I. H. I. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000182230.47819.aa · Cited by 327 · see citing works
Veterans Aging Cohort Study (VACS)
Justice, A. C., Dombrowski, E., Conigliaro, J. C., Fultz, S. L., Gibson, D., Madenwald, T., Goulet, J. L., Simberkoff, M. S., Butt, A. A., Rimland, D., et al. (2006) · Medical Care · doi:10.1097/01.mlr.0000223741.02074.66 · Cited by 322 · see citing works
Self-citation
Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine
Levin, M. J., Smith, J. G., Kaufhold, R. M., Barber, D., Hayward, A. R., Chan, C. Y., Chan, I. S. F., Li, D. J. J., Wang, W., Keller, P. M., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/379048 · Cited by 314 · see citing works
Characteristics, Determinants, and Clinical Relevance of CD4 T Cell Recovery to <500 Cells/ L in HIV Type 1--Infected Individuals Receiving Potent Antiretroviral Therapy
Kaufmann, G. R., Furrer, H.-J., Ledergerber, B., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/431484 · Cited by 313 · see citing works
Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
Milito, A. D., Nilsson, A., Titanji, K., Thorstensson, R., Reizenstein, E., Narita, M., Grützmeier, S., Sönnerborg, A. B., & Chiodi, F. (2003) · Blood · doi:10.1182/blood-2003-07-2375 · Cited by 311 · see citing works
Aging, Immunity, and the Varicella–Zoster Virus
Arvin, A. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmp058091 · Cited by 305 · see citing works
Herpes Zoster and Human Immunodeficiency Virus Infection
Buchbinder, S., Katz, M. H., Hessol, N. A., Liu, J. Y., O’Malley, P. M., Underwood, R., & Holmberg, S. D. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.5.1153 · Cited by 302 · see citing works
The SCID-hu mouse as a model for HIV-1 infection
Aldrovandi, G. M., Feuer, G., Gao, L., et al. (1993) · Nature · doi:10.1038/363732a0 · Cited by 286 · see citing works
The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284 · see citing works
Patient Perceptions of Quality of Life With Diabetes-Related Complications and Treatments
Huang, E. S., Brown, S. E. S., Ewigman, B., Foley, E. C., & Meltzer, D. O. (2007) · Diabetes Care · doi:10.2337/dc07-0499 · Cited by 284 · see citing works
Incidence of Opportunistic and Other Infections in HIV-Infected Children in the HAART Era
Gona, P. N., Dyke, R. B. V., Williams, P. L., et al. (2006) · JAMA · doi:10.1001/jama.296.3.292 · Cited by 279 · see citing works
Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy
Hunt, P. W., Deeks, S. G., Rodriguez, B. A., Valdez, H., Shade, S. B., Abrams, D. I., Kitahata, M. M., Krone, M., Neilands, T. B., Brand, R., et al. (2003) · AIDS · doi:10.1097/00002030-200309050-00009 · Cited by 273 · see citing works
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270 · see citing works
Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function
Teixeira, L., Valdez, H., McCune, J. M., Koup, R. A., Badley, A. D., Hellerstein, M. K., Napolitano, L. A., Douek, D. C., Mbisa, G. L., Deeks, S. G., et al. (2001) · AIDS · doi:10.1097/00002030-200109280-00002 · Cited by 249 · see citing works
Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection
Guadalupe, M., Sankaran, S., George, M. D., Reay, E., Verhoeven, D. E., Shacklett, B. L., Flamm, J., Wegelin, J. A., Prindiville, T. P., & Dandekar, S. (2006) · Journal of Virology · doi:10.1128/jvi.00120-06 · Cited by 248 · see citing works
Weight Loss and Wasting Remain Common Complications in Individuals Infected with Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Therapy
Wanke, C. A., Silva, M., Knox, T. A., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/314027 · Cited by 248 · see citing works
Chronic renal failure among HIV-1-infected patients
Mocroft, A., Kirk, O., Gatell, J. M., Reiss, P., Gargalianos, P., Zilmer, K., Beniowski, M., Viard, J., Staszewski, S., & Lundgren, J. D. (2007) · AIDS · doi:10.1097/qad.0b013e3280f774ee · Cited by 227 · see citing works
Influence of Age on CD4 Cell Recovery in Human Immunodeficiency Virus–Infected Patients Receiving Highly Active Antiretroviral Therapy: Evidence from the EuroSIDA Study
Viard, J., Mocroft, A., Chiesi, A., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/319678 · Cited by 220 · see citing works
The impact of patients' preferences on the treatment of atrial fibrillation: observational study of patient based decision analysis Commentary: patients, preferences, and evidence
Protheroe, J. (2000) · BMJ · doi:10.1136/bmj.320.7246.1380 · Cited by 219 · see citing works
Medication Adherence in Elderly Patients Receiving Home Health Services following Hospital Discharge
Gray, S. L., Mahoney, J., & Blough, D. K. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.10295 · Cited by 209 · see citing works
The metabolic effects of lopinavir/ritonavir in HIV-negative men
Lee, G. A., Seneviratne, T., Noor, M. A., Lo, J. C.-M., Schwarz, J., Aweeka, F. T., Mulligan, K. M., Schambelan, M., & Grünfeld, C. (2004) · AIDS · doi:10.1097/00002030-200403050-00008 · Cited by 205 · see citing works
BRIEF REPORT: The burden of diabetes therapy
Vijan, S. S., Hayward, R. A., Ronis, D. L., & Hofer, T. P. (2005) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2005.0117.x · Cited by 203 · see citing works
Effects of patients' preferences on the treatment of atrial fibrillation: observational study of patient-based decision analysis
Protheroe, J. (2001) · Western Journal of Medicine · doi:10.1136/ewjm.174.5.311 · Cited by 201 · see citing works
A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy
Cohen, C. J., Hunt, S. C., Sension, M., et al. (2002) · AIDS · doi:10.1097/00002030-200203080-00009 · Cited by 197 · see citing works
The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults
Noor, M. A., Parker, R. A., O'Mara, E. M., Grasela, D. M., Currie, A., Hodder, S., Fiedorek, F. T., & Haas, D. W. (2004) · AIDS · doi:10.1097/00002030-200411050-00005 · Cited by 197 · see citing works
Barriers to following dietary recommendations in type 2 diabetes
Vijan, S., Stuart, N. S., Fitzgerald, J. T., Ronis, D. L., Hayward, R. A., Slater, S., & Hofer, T. P. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01342.x · Cited by 195 · see citing works
CD28 Expression in T Cell Aging and Human Longevity
Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00132-0 · Cited by 194 · cited 1× · see citing works
“The percentage of CD4+ T cells that are CD28− rarely exceeds 10% in older individuals, whereas CD28− T cells can represent >70% of CD8+ T cells during very advanced age [47].”
Self-citation
Global strategies to prevent bacterial pneumonia in adults with HIV disease
Feikin, D. R., Feldman, C. H., Schuchat, A., & Janoff, E. N. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01060-6 · Cited by 193 · see citing works
Self-citation
Immunologic and clinical responses to highly active antiretroviral therapy over 50 years of age. Results from the French Hospital Database on HIV
Grabar, S., Kousignian, I., Sobel, A. T., Bras, P. L., Gasnault, J., Enel, P., Jung, C., Mahamat, A., Lang, J.-M., & Costagliola, D. G. (2004) · AIDS · doi:10.1097/00002030-200410210-00007 · Cited by 188 · see citing works
Intentional Prescription Nonadherence (Noncompliance) by the Elderly
Cooper, J. K., Love, D. W., & Raffoul, P. R. (1982) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1982.tb05623.x · Cited by 186 · see citing works
Managing multiple morbidity in mid-life: A qualitative study of attitudes to drug use
Townsend, A., Hunt, K., & Wyke, S. (2003) · BMJ · doi:10.1136/bmj.327.7419.837 · Cited by 181 · see citing works
Incidence and etiology of acute renal failure among ambulatory HIV-infected patients
Franceschini, N., Napravnik, S., Eron, J. J., et al. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00232.x · Cited by 180 · see citing works
Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study
Yamashita, T. E., Phair, J., Muñoz, Á., Margolick, J. B., Detels, R., O’Brien, S. J., Mellors, J. W., Wolinsky, S. M., & Jacobson, L. P. (2001) · AIDS · doi:10.1097/00002030-200104130-00009 · Cited by 178 · see citing works
Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population
Darby, I., Ewart, D. W., Giangrande, I., Spooner, R. J. D., & Rizza, C. R. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91073-9 · Cited by 177 · see citing works
Chronic kidney disease in HIV infection: an urban epidemic
Wyatt, C. M., Winston, J. A., Malvestutto, C., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3282ef1bb4 · Cited by 177 · see citing works
Varicella and Herpes Zoster
Weller, T. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312083092306 · Cited by 173 · see citing works
End-stage liver disease in persons with hemophilia and transfusion-associated infections.
Goedert, J. J., Eyster, M. E., Lederman, M. M., Mandalaki, T., de Moerloose, P., White, G., Angiolillo, A. L., Luban, N. L. C., Sherman, K. E., Manco‐Johnson, M. J., et al. (2002) · PubMed · Cited by 171 · see citing works
Postherpetic neuralgia.
Hope-Simpson, R. E. (1975) · PubMed · Cited by 170 · see citing works
Selective Impairments in Dendritic Cell-Associated Function Distinguish Hepatitis C Virus and HIV Infection
Anthony, D. D., Yonkers, N. L., Post, A. B., Asaad, R. J., Heinzel, F. P., Lederman, M. M., Lehmann, P., & Valdez, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4907 · Cited by 165 · see citing works
Effect of Baseline- and Treatment-Related Factors on Immunologic Recovery After Initiation of Antiretroviral Therapy in HIV-1-Positive Subjects
Gandhi, R. T., Spritzler, J., Chan, E. S., et al. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000226789.51992.3f · Cited by 165 · see citing works
Long‐Term Clinical Outcome of Human Immunodeficiency Virus–Infected Patients with Discordant Immunologic and Virologic Responses to a Protease Inhibitor–Containing Regimen
Piketty, C., Weiss, L., Thomas, F., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/319861 · Cited by 159 · see citing works
Discordant Immunologic and Virologic Responses to Highly Active Antiretroviral Therapy Are Associated With Increased Mortality and Poor Adherence to Therapy
Moore, D. M., Hogg, R. S., Yip, B., Wood, E., TYNDALL, M. W., Braitstein, P. K. A., & Montaner, J. S. G. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000182847.38098.d1 · Cited by 158 · see citing works
Age‐Related Immune Dysfunction in Health and in Human Immunodeficiency Virus (HIV) Disease: Association of Age and HIV Infection with Naive CD8+Cell Depletion, Reduced Expression of CD28 on CD8+Cells, and Reduced Thymic Volumes
Kalayjian, R. C., LANDAY, A. L., Pollard, R. B., Taub, D. D., Gross, B. H., Francis, I. R., Sevin, A. D., Pu, M., Spritzler, J., Chernoff, M., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/375372 · Cited by 158 · see citing works
Immunopathogenesis of acute AIDS virus infection
Picker, L. J. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.05.001 · Cited by 158 · see citing works
Effect of age at seroconversion on the natural AIDS incubation distribution
Rosenberg, P. S., & Goedert, J. J. (1994) · AIDS · doi:10.1097/00002030-199406000-00013 · Cited by 156 · see citing works
Changes in haemoglobin during interferon alpha‐2b plus ribavirin combination therapy for chronic hepatitis C virus infection
Sulkowski, M., Wasserman, R. B., Brooks, L., et al. (2004) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2004.00490.x · Cited by 155 · see citing works
Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria
Uneke, C. J., Ogbu, O., Inyama, P., et al. (2005) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762005000100002 · Cited by 155 · see citing works
Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
Titanji, K., Chiodi, F., Bellocco, R., Schepis, D., Osorio, L. M., Tassandin, C., Tambussi, G., Grützmeier, S., Lopalco, L., & Milito, A. D. (2005) · AIDS · doi:10.1097/01.aids.0000191231.54170.89 · Cited by 154 · see citing works
Insulin sensitivity and insulin clearance in human immunodeficiency virus-infected men
Hommes, M. J. T., Romijn, J. A., Endert, E., Schattenkerk, J. K. M. E., & Sauerwein, H. P. (1991) · Metabolism · doi:10.1016/0026-0495(91)90059-6 · Cited by 150 · see citing works
Changing Trends in the Survival of Dialysis Patients with Human Immunodeficiency Virus in the United States
Ahuja, T. S., Grady, J. J., & Khan, S. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000019773.43765.bf · Cited by 149 · see citing works
Lymphatic Tissue Fibrosis Is Associated with Reduced Numbers of Naive CD4 + T Cells in Human Immunodeficiency Virus Type 1 Infection
Schacker, T. W., Brenchley, J. M., Beilman, G. J., Reilly, C., Pambuccian, S. E., Taylor, J. H., Skarda, D. E., Larson, M. C., Douek, D. C., & Haase, A. T. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.13.5.556-560.2006 · Cited by 140 · see citing works
The incidence of herpes zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.15.1605 · Cited by 139 · see citing works
Communication factors in the follow-up of abnormal mammograms
Poon, E. G., Haas, J. S., Puopolo, A. L., Gandhi, T. K., Burdick, E., Bates, D. W., & Brennan, T. A. (2004) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2004.30357.x · Cited by 138 · see citing works
Patterns of the hazard of death after AIDS through the evolution of antiretroviral therapy: 1984–2004
Schneider, M. F., Gange, S. J., Williams, C. M., et al. (2005) · AIDS · doi:10.1097/01.aids.0000189864.90053.22 · Cited by 136 · see citing works
Exercise Training in HIV-1-Infected Individuals with Dyslipidemia and Lipodystrophy
TERRY, L., Sprinz, E., Stein, R., MEDEIROS, N. B., OLIVEIRA, J., & Ribeiro, J. P. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000191347.73848.80 · Cited by 135 · see citing works
Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins
Palmer, L. D., Weng, N.-P., Levine, B. L., June, C. H., Lane, H. C., & Hodes, R. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1381 · Cited by 129 · see citing works
End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004
Lucas, G. M., Mehta, S. H., Atta, M. G., Kirk, G. D., Galai, N., Vlahov, D., & Moore, R. D. (2007) · AIDS · doi:10.1097/qad.0b013e32827038ad · Cited by 128 · see citing works
Class-Specific Antibody Response to Pneumococcal Capsular Polysaccharides in Men Infected with Human Immunodeficiency Virus Type 1
Janoff, E. N., Douglas, J. M., Gabriel, M., et al. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.5.983 · Cited by 127 · see citing works
Self-citation
Lack of Decay of HIV-1 in Gut-Associated Lymphoid Tissue Reservoirs in Maximally Suppressed Individuals
Poles, M. A., Boscardin, W. J., Elliott, J. E., et al. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000230524.71717.14 · Cited by 123 · see citing works
Fat Distribution in Women With HIV Infection
Infection, F. T. S. O. F. R. A. M. C. I. H. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000229996.75116.da · Cited by 121 · see citing works
The Incidence of, Risk Factors for, and Sequelae of Herpes Zoster Among HIV Patients in the Highly Active Antiretroviral Therapy Era
Gebo, K. A., Kalyani, R. R., Moore, R. D., et al. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000178408.62675.b0 · Cited by 120 · see citing works
Self-citation
Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans
Goulet, J. L., Fultz, S. L., McGinnis, K. A., & Justice, A. C. (2005) · AIDS · doi:10.1097/01.aids.0000192077.11067.e5 · Cited by 120 · see citing works
Self-citation
Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
Schacker, T. W., Reilly, C., Beilman, G. J., Taylor, J. H., Skarda, D. E., Krason, D. A., Larson, M. C., & Haase, A. T. (2005) · AIDS · doi:10.1097/01.aids.0000194801.51422.03 · Cited by 119 · see citing works
The dynamics of CD4+ T-lymphocyte decline in HIV-infected individuals: a Markov modeling approach.
Longini, I. M., Ws, C., Gardner, L. I., et al. (1991) · PubMed · Cited by 116 · see citing works
Varicella-Zoster Virus
(2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511601194 · Cited by 115 · see citing works
Unique Aspects of Antimicrobial Use in Older Adults
Faulkner-Fennell, C., Cox, H. L., & Williamson, J. (2005) · Clinical Infectious Diseases · doi:10.1086/428125 · Cited by 114 · see citing works
Paucity of Antigen-Specific IgA Responses in Sera and External Secretions of HIV-Type 1-Infected Individuals
Mestecky, J. F., Jackson, S., Moldoveanu, Z., Nesbit, L. R., Kulhavy, R., Prince, S. J., Sabbaj, S., Mulligan, M. J., & Goepfert, P. (2004) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2004.20.972 · Cited by 113 · see citing works
HIV Infection in Older Adults
Luther, V. P., & Wilkin, A. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2007.02.004 · Cited by 113 · see citing works
Incidence of Lipoatrophy and Lipohypertrophy in the Women's Interagency HIV Study
Tien, P. C., Cole, S. R., Williams, C. M., Li, R., Justman, J. E., Cohen, M. H., Young, M., Rubin, N., Augenbraun, M. H., & Grünfeld, C. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200312150-00003 · Cited by 109 · see citing works
A New Paradigm for Clinical Investigation of Infectious Syndromes in Older Adults: Assessment of Functional Status as a Risk Factor and Outcome Measure
High, K. P., Bradley, S., Loeb, M. B., Palmer, R. M., Quagliarello, V., & Yoshikawa, T. T. (2004) · Clinical Infectious Diseases · doi:10.1086/426082 · Cited by 106 · see citing works
Self-citation
Reduced Aerobic Capacity and Physical Functioning in Older HIV-Infected Men
Oursler, K. K., Sorkin, J. D., Smith, B. A., & Katzel, L. I. (2006) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.22.1113 · Cited by 106 · see citing works
Greater Effect of Highly Active Antiretroviral Therapy on Survival in People Aged ⩾50 Years Compared with Younger People in an Urban Observational Cohort
Perez, J. L., & Moore, R. D. (2003) · Clinical Infectious Diseases · doi:10.1086/345669 · Cited by 106 · see citing works
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti, P., Phillips, A. N., Dorrucci, M., et al. (1996) · BMJ · doi:10.1136/bmj.313.7057.583 · Cited by 104 · see citing works
Decreased cell proliferation and altered cytokine production in frail older adults
Leng, S. X., Yang, H., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03327392 · Cited by 101 · see citing works
Long-Term Body Composition and Metabolic Changes in Antiretroviral Naive Persons Randomized to Protease Inhibitor-, Nonnucleoside Reverse Transcriptase Inhibitor-, or Protease Inhibitor Plus Nonnucleoside Reverse Transcriptase Inhibitor-Based Strategy
Shlay, J. C., Bartsch, G. E., Peng, G., Wang, J., Grünfeld, C., Gibert, C. L., Visnegarwala, F., Raghavan, S. S., Xiang, Y., Farrough, M., et al. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31804216cf · Cited by 98 · see citing works
Progression of Human Immunodeficiency Virus Type 1 (HIV-1) Infection among Homosexual Men in Hepatitis B Vaccine Trial Cohorts in Amsterdam, New York City, and San Francisco, 1978–1991
Hessol, N. A., Koblin, B. A., van Griensven, F., et al. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116951 · Cited by 97 · see citing works
Antiretroviral Treatment Patterns and Incident HIV-Associated Morphologic and Lipid Abnormalities in a Population-Based Cohort
Heath, K., Hogg, R. S., Singer, J., Chan, K., O’Shaughnessy, M. V., & Montaner, J. S. G. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200208010-00010 · Cited by 96 · see citing works
Accelerated replicative senescence of the peripheral immune system induced by HIV infection
Bestilny, L. J., Gill, M. J., Mody, C. H., & Riabowol, K. T. (2000) · AIDS · doi:10.1097/00002030-200005050-00002 · Cited by 95 · see citing works
Determinants of HIV Disease Progression among Homosexual Men Registered in the Tricontinental Seroconverter Study
Veugelers, P. J., Page, K. A., Tindall, B., Schechter, M. T., Moss, A. R., Winkelstein, W., Cooper, D. A., Craib, K. J. P., Charlebois, E. D., Coutinho, R. A., et al. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117322 · Cited by 93 · see citing works
Screening Mammography for Frail Older Women. What are the Burdens?*
Walter, L. C., Eng, C., & Covinsky, K. E. (2001) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2001.10113.x · Cited by 90 · see citing works
Trends in perimortal conditions and mortality rates among HIV-infected patients
Hooshyar, D., Hanson, D. L., Wolfe, M. I., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3282e9a664 · Cited by 86 · see citing works
Effect of resistance training on self-reported physical functioning in HIV infection
Roubenoff, R., & Wilson, I. B. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200111000-00003 · Cited by 84 · see citing works
Ribavirin pharmacokinetics in renal and liver transplant patients: evidence that it depends on renal function
Kamar, N., Chatelut, É., Manolis, E., et al. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.09.019 · Cited by 84 · see citing works
The incubation period of AIDS.
Muñoz, Á., Sabin, C. A., & Phillips, A. N. (1997) · PubMed · Cited by 83 · see citing works
Response to highly active antiretroviral therapy in HIV-infected patients aged 60 years or older after 24 months follow-up
Knobel, H., Guelar, A., Valldecillo, G., et al. (2001) · AIDS · doi:10.1097/00002030-200108170-00025 · Cited by 80 · see citing works
Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase
Lederman, M. M., McKinnis, R. A., Kelleher, D. L., et al. (2000) · AIDS · doi:10.1097/00002030-200012010-00002 · Cited by 79 · see citing works
Seroprevalence of hepatitis B and C and HIV in Malawian pregnant women
Ahmed, S. D., Cuevas, L. E., Brabin, B. J., et al. (1998) · Journal of Infection · doi:10.1016/s0163-4453(98)91983-1 · Cited by 78 · see citing works
HIV protease inhibitors increase TNF-α and IL-6 expression in macrophages: Involvement of the RNA-binding protein HuR
Zhou, H., Brimson, S. J., Gurley, E. C., Chen, L., Ding, H., Studer, E. J., Pandak, W. M., Hu, W., Zou, T., Wang, J., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.04.008 · Cited by 77 · see citing works
All-or-nothing treatment targets make bad performance measures.
Hayward, R. A. (2007) · PubMed · Cited by 76 · see citing works
A case–control study of virological and immunological effects of highly active antiretroviral therapy in HIV-infected patients with advanced age
Manfredi, R., & Chiodo, F. (2000) · AIDS · doi:10.1097/00002030-200007070-00034 · Cited by 76 · see citing works
Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are Susceptible: Evidence for a Cell-Type-Specific Apoptotic Response
Hood, C. L., Cunningham, A. L., Slobedman, B., Boadle, R. A., & Abendroth, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.23.12852-12864.2003 · Cited by 74 · see citing works
Impact of aging on gastrointestinal mucosal immunity
Schmucker, D. L., Heyworth, M., Owen, R., & Daniels, C. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02088236 · Cited by 73 · see citing works
Older age does not influence CD4 cell recovery in HIV-1 infected patients receiving Highly Active Anti Retroviral Therapy
Tumbarello, M., Ricardo Rabagliati, B., Donati, K. D. G., et al. (2004) · BMC Infectious Diseases · doi:10.1186/1471-2334-4-46 · Cited by 72 · see citing works
Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse
McGinnis, K. A., Fultz, S. L., Skanderson, M., Conigliaro, J. C., BRYANT, K. J., & Justice, A. C. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.7984 · Cited by 72 · see citing works
Self-citation
Prevalence and incidence of hepatitis B virus infection in STD clinic attendees in Pune, India
Risbud, A. (2002) · Sexually Transmitted Infections · doi:10.1136/sti.78.3.169 · Cited by 71 · see citing works
TLR Ligand-Dependent Activation of Naive CD4 T Cells by Plasmacytoid Dendritic Cells Is Impaired in Hepatitis C Virus Infection
Yonkers, N. L., Rodriguez, B. A., Milkovich, K. A., Asaad, R. J., Lederman, M. M., Heeger, P. S., & Anthony, D. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4436 · Cited by 71 · see citing works
Evaluating Liver Fibrosis Progression and the Impact of Antiretroviral Therapy in HIV and Hepatitis C Coinfection Using a Noninvasive Marker
Al-Mohri, H. A., Murphy, T. J., Lu, Y., et al. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318030ff8e · Cited by 62 · see citing works
When there is too much to do
Hofer, T. P., Zemencuk, J. K., & Hayward, R. A. (2004) · Journal of General Internal Medicine · doi:10.1007/s11606-004-0058-0 · Cited by 62 · see citing works
Primary HIV-1 Infection Sets the Stage for Important B Lymphocyte Dysfunctions
Titanji, K., Chiodi, F., Bellocco, R., Schepis, D., Cagigi, A., Osorio, L. M., Tassandin, C., Tambussi, G., Grützmeier, S., Lopalco, L., et al. (2005) · Retrovirology · doi:10.1186/1742-4690-2-s1-p95 · Cited by 61 · see citing works
Older age and plasma viral load in HIV-1 infection
Goodkin, K., Shapshak, P., Asthana, D., et al. (2004) · AIDS · doi:10.1097/00002030-200401001-00013 · Cited by 60 · see citing works
Older HIV-positive patients in the era of highly active antiretroviral therapy
Tumbarello, M., Ricardo Rabagliati, B., Donati, K. D. G., et al. (2003) · AIDS · doi:10.1097/00002030-200301030-00020 · Cited by 60 · see citing works
Clinical pharmacodynamics of HIV-1 protease inhibitors: use of inhibitory quotients to optimise pharmacotherapy
Morse, G. D., Catanzaro, L. M., & Acosta, E. P. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70436-4 · Cited by 55 · see citing works
Diversity of the Ig Repertoire is Maintained With Age In Spite of Reduced Germinal Centre Cells in Human Tonsil Lymphoid Tissue
Kolar, G. R., Mehta, D., Wilson, P. C., & Capra, J. D. (2006) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2006.01817.x · Cited by 52 · see citing works
Epidemiology and costs of herpes zoster: Background data to estimate the impact of vaccination
Legami, V. D., Gianino, M. M., Atti, M. L. C. D., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.07.049 · Cited by 52 · see citing works
HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset
Eylar, E. H., Lefranc, C. E., Yamamura, Y., Baez, I. C., Colón-Martinez, S. L., Rodríguez, N., & Breithaupt, T. B. (2001) · BMC Immunology · doi:10.1186/1471-2172-2-10 · Cited by 47 · see citing works
Virologic and Immunologic Effect of Antiretroviral Therapy on HIV-1 in Gut-Associated Lymphoid Tissue
Talal, A. H., Monard, S. P., Vesanen, M., et al. (2001) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200101010-00001 · Cited by 47 · see citing works
Clinical Experience with Human Immunodeficiency Virus–Infected Older Patients in the Era of Effective Antiretroviral Therapy
Grimes, R. M., Otiniano, M. E., Rodriguez‐Barradas, M. C., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/340404 · Cited by 47 · see citing works
Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes
Xie, D., & McElhaney, J. E. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.05.001 · Cited by 44 · see citing works
Peripheral S‐Phase T Cells in HIV Disease Have a Central Memory Phenotype and Rarely Have Evidence of Recent T Cell Receptor Engagement
Sieg, S. F., Rodriguez, B. A., Asaad, R. J., Jiang, W., Bazdar, D. A., & Lederman, M. M. (2005) · The Journal of Infectious Diseases · doi:10.1086/430620 · Cited by 44 · see citing works
Impact of HIV-1 Infection on VH3 Gene Repertoire of Naive Human B Cells
Scamurra, R. W., Miller, D. J., Dahl, L., Abrahamsen, M. S., Kapur, V., Wahl, S. M., MILNER, E. C. B., & Janoff, E. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5482 · Cited by 43 · see citing works
Self-citation
Replicative Senescence: The Final Stage of Memory T Cell Differentiation?
Effros, R. B. (2003) · Current HIV Research · doi:10.2174/1570162033485348 · Cited by 43 · see citing works
Self-citation
Antiretroviral Treatment and Advanced Age: Epidemiologic, Laboratory, and Clinical Features in the Elderly
Manfredi, R., Calza, L., Cocchi, D., et al. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200305010-00016 · Cited by 43 · see citing works
Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders
Csako, G., McGriff, N. J., Rotman-Pikielny, P., Sarlis, N. J., & Pucino, F. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.1a031 · Cited by 40 · see citing works
A New Paradigm for Clinical Investigation of Infectious Syndromes in Older Adults: Assessing Functional Status as a Risk Factor and Outcome Measure
High, K. P., Bradley, S., Loeb, M. B., Palmer, R. M., Quagliarello, V., & Yoshikawa, T. T. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53240.x · Cited by 39 · see citing works
Self-citation
Distinct Mechanisms of T Cell Reconstitution Can Be Identified by Estimating Thymic Volume in Adult HIV‐1 Disease
Kalayjian, R. C., Spritzler, J., Pu, M., LANDAY, A. L., Pollard, R. B., Stocker, V. L., Harthi, L.-A., Gross, B. H., Francis, I. R., Fiscus, S. A., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/466527 · Cited by 36 · see citing works
Herpes zoster and HIV-1 infection in a rural Ugandan cohort
Morgan, D., Mahé, C., Malamba, S. S., et al. (2001) · AIDS · doi:10.1097/00002030-200101260-00012 · Cited by 34 · see citing works
Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: a prospective observational study
Hung, C., Hsiao, C., Wang, J., et al. (2005) · International Journal of STD & AIDS · doi:10.1258/095646205774357271 · Cited by 34 · see citing works
T Cell Replicative Senescence Pleiotropic Effects on Human Aging
Effros, R. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.022 · Cited by 33 · see citing works
Self-citation
Impaired Induction of CD27 and CD28 Predicts Naive CD4 T Cell Proliferation Defects in HIV Disease
Luciano, A. A., Lederman, M. M., Valentin-Torres, A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3543 · Cited by 31 · see citing works
Gynecomastia Associated with Highly Active Antiretroviral Therapy
Manfredi, R., Calza, L., & Chiodo, F. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.10274 · Cited by 29 · see citing works
Mitochondrial Abnormalities in HIV-Infected Lipoatrophic Patients Treated With Antiretroviral Agents
Chapplain, J.-M., Beillot, J., Bégué, J., et al. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000138982.68106.6c · Cited by 28 · see citing works
CYTOKINE RESPONSES DIFFER BY COMPARTMENT AND WASTING STATUS IN PATIENTS WITH HIV INFECTION AND HEALTHY CONTROLS
Abad, L. W., Schmitz, H. R., Parker, R., & Roubenoff, R. (2002) · Cytokine · doi:10.1006/cyto.2002.0893 · Cited by 26 · see citing works
Inclusion of Older Women in Randomized Clinical Trials: Factors Associated with Taking Study Medication in the Fracture Intervention Trial
Buist, D. S. M., LaCroix, A. Z., Black, D. M., Harris, F., Blank, J., Ensrud, K. E., Edgerton, D., Rubin, S., & Fox, K. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04790.x · Cited by 24 · see citing works
Relation of Stavudine Discontinuation to Anthropometric Changes Among HIV-Infected Women
Tien, P. C., Schneider, M. F., Cole, S. R., et al. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000248353.56125.43 · Cited by 20 · see citing works
Prevalence of hepatitis B virus (HBV) infection in Singapore men with sexually transmitted diseases and HIV infection: role of sexual transmission in a city state with intermediate HBV endemicity.
Heng, B. H., Goh, K. T., Chan, R. C. W., et al. (1995) · Journal of Epidemiology & Community Health · doi:10.1136/jech.49.3.309 · Cited by 20 · see citing works
Seroprevalence of sexually transmitted viruses in Korean populations including HIV-seropositive individuals
Kim, O., Kim, S.-S., Park, M., et al. (2003) · International Journal of STD & AIDS · doi:10.1258/095646203321043264 · Cited by 20 · see citing works
Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells Is Only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection
Sieg, S. F., Bazdar, D. A., & Lederman, M. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5208 · Cited by 20 · see citing works
Progression to CMV end-organ disease in HIV-1-infected individuals despite abundance of highly differentiated CMV-specific CD8+ T-cells
Bronke, C., Westerlaken, G. H. A., Miedema, F. F., Tesselaar, K., & van Baarle, D. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.11.004 · Cited by 18 · see citing works
Epidemiology of herpes zoster
Schmader, K. E. (2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511601194.014 · Cited by 14 · see citing works
Self-citation
Tumor Necrosis Factor-α Levels in Patients with HIV with Wasting in South Asia
Wig, N., Anupama, P., Singh, S., et al. (2005) · AIDS Patient Care and STDs · doi:10.1089/apc.2005.19.212 · Cited by 13 · see citing works
Efavirenz: innocent bystander or direct nephrotoxin?
Wyatt, C. M., Rodriguez-Caprio, G., & Klotman, P. E. (2007) · AIDS · doi:10.1097/qad.0b013e3281722246 · Cited by 10 · see citing works
Introduction
Volberding, P. A., & Lange, J. M. A. (2001) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200103011-00001 · Cited by 10 · see citing works
Assessing kidney function in HIV infection.
Winston, J. A. (2007) · PubMed · Cited by 10 · see citing works
Managing HIV Infection in Middle Aged and Older Populations
Gebo, K. A., & Moore, R. D. (2005) · Aging Health · doi:10.2217/1745509x.1.3.395 · Cited by 3 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 2

[124]Wohl D Currier J Scherzer R Gender and race/ethnicity differences in dyslipidemia among HIV-infected patients participating in the Fat Redistribution and Metabolic Change cohort study [abstract 750] Program and abstracts of the 13th Conference on Retro-viruses and Opportunistic Infections Denver, CO 2006
[129]Seaberg E Riddler S Margolick J Multicenter AIDS Cohort Study (MACS). The effect of HAART on blood pressure Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections Boston, MA 2005

Sorted by citations

. Premature Age-Related Comorbidities Among HIV-Infected Persons Compared with the General Population.
Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir627 · Cited by 1,331 · see citing works
HIV-1 infection accelerates age according to the epigenetic clock
Horvath, S., & Levine, A. J. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv277 · Cited by 556 · see citing works
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522 · see citing works
Self-citation
HIV and aging: time for a new paradigm.
Justice, A. C. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0041-9 · Cited by 309 · see citing works
Self-citation
Social Care Networks and Older LGBT Adults: Challenges for the Future
Brennan-Ing, M., Seidel, L., Larson, B., & Karpiak, S. E. (2014) · Journal of Homosexuality · doi:10.1080/00918369.2013.835235 · Cited by 167 · see citing works
. Towards a combined prognostic index for survival in HIV infection: the role of non-HIV biomarkers.
Justice, A., McGinnis, K., Skanderson, M., Chang, C., Gibert, C., Goetz, M., Rimland, D., Rodriguez‐Barradas, M., Oursler, K., Brown, S., et al. (2010) · HIV Medicine · doi:10.1111/j.1468-1293.2009.00757.x · Cited by 159 · see citing works
. Patterns of drug use and abuse among aging adults with and without HIV: a latent class analysis of a US Veteran cohort.
Green, T. C., Kershaw, T., Lin, H., Heimer, R., Goulet, J. L., Kraemer, K. L., Gordon, A. J., Maisto, S. A., Day, N. L., Bryant, K., et al. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.02.020 · Cited by 101 · see citing works
Self-citation
In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs
Hukezalie, K. R., Thumati, N. R., Côté, H. C. F., & Wong, J. M. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047505 · Cited by 84 · see citing works
Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells
Chou, J. P., Ramirez, C. M., Wu, J. E., & Effros, R. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064702 · Cited by 78 · see citing works
Self-citation
. A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus.
Shah, K., Hilton, T. N., Myers, L., Pinto, J. F., Luque, A. E., & Hall, W. J. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03819.x · Cited by 77 · see citing works
The silent war of CMV in aging and HIV infection
Effros, R. B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.09.003 · Cited by 63 · see citing works
Self-citation

Authors: Effros, R. B., Fletcher, C. V., Gebo, K., Halter, J. B., Hazzard, W. R., Horne, F. M., Huebner, R. E., Janoff, E. N., Justice, A. C., Kuritzkes, D., Nayfield, S. G., Plaeger, S. F., Schmader, K. E., Ashworth, J. R., Campanelli, C., Clayton, C. P., Rada, B., Woolard, N. F., & High, K. P.
Affiliations: University of California, Los Angeles (US)
University of Nebraska at Omaha (US)
Johns Hopkins University (US)
University of Michigan (US)
VA Puget Sound Health Care System (US)
National Institutes of Health (US)
University of Colorado Anschutz (US)
Yale University (US)
Brigham and Women's Hospital (US)
Duke University (US)
American Geriatrics Society (US)
Infectious Diseases Society of America (US)
Wake Forest University Health Sciences (US)
ORCID: Effros, Rita B.
Fletcher, Courtney V.
Gebo, Kelly
Janoff, Edward N.
Justice, Amy C.
Kuritzkes, Daniel
Schmader, Kenneth E.
Woolard, Nancy F.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2008-08-15
Volume: 47
Issue: 4
Pages: 542-553
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/590150
PMC: PMC3130308
OpenAlex: W2095748010
Cited by: 539
References: 178
Citations by year: 2026: 4 · 2025: 6 · 2024: 11 · 2023: 15 · 2022: 17 · 2021: 11 · 2020: 27 · 2019: 17 · 2018: 18 · 2017: 35 · 2016: 42 · 2015: 51 · 2014: 64 · 2013: 70 · 2012: 49
FWCI: 37.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (U10AA013566)
Topics: Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV infection, aging, AIDS, highly active antiretroviral therapy, comorbidities, frailty, drug toxicity, research priorities
MeSH terms: Adolescent, Adult, Aged, Aging, Child, Humans, Immunity, Kidney Diseases, Liver Diseases, Metabolic Diseases, Middle Aged, Research, HIV-1, HIV Infections, Age Distribution, Antiretroviral Therapy, Highly Active

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks