The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)
Open accessAbstract
The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity. Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R–associated kinase. Tumor necrosis factor receptor–activated factor 6 (TRAF6) and the nuclear factor κB (NF-κB)–inducing kinase (NIK) are both involved in subsequent steps of NF-κB activation. Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.
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Cites
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Cited by
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Metadata
- Authors
- Muzio, M., Natoli, G., Saccani, S., Levrero, M., & Mantovani, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-06-15
- Volume
- 187
- Issue
- 12
- Pages
- 2097-2101
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2157086104
- Cited by
- 574
- References
- 3
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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