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Cited by 566

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells

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Zamai, Loris, Ahmad, Manzoor, Bennett, Ian M., Azzoni, Livio, Alnemri, Emad S., Perussia, Bice·1998·The Journal of Experimental Medicine
DOI 10.1084/jem.188.12.2375
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Abstract

Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted cytokines (tumor necrosis factor [TNF]-α) to induce target cell death. Fas belongs to the TNF receptor family of molecules, containing a conserved intracytoplasmic “death domain” that indirectly activates the caspase enzymatic cascade and ultimately apoptotic mechanisms in numerous cell types. Two additional members of this family, DR4 and DR5, transduce apoptotic signals upon binding soluble TNF-related apoptosis-inducing ligand (TRAIL) that, like FasL, belongs to the growing TNF family of molecules. Here, we report that TRAIL produced or expressed by different populations of primary human NK cells is functional, and represents a marker of differentiation or activation of these, and possibly other, cytotoxic leukocytes. During differentiation NK cells, sequentially and differentially, use distinct members of the TNF family or granule exocytosis to mediate target cell death. Phenotypically immature CD161+/CD56− NK cells mediate TRAIL-dependent but not FasL- or granule release–dependent cytotoxicity, whereas mature CD56+ NK cells mediate the latter two.

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Metadata

Authors
Zamai, L., Ahmad, M., Bennett, I. M., Azzoni, L., Alnemri, E. S., & Perussia, B.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
1998-12-21
Volume
188
Issue
12
Pages
2375-2380
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.188.12.2375
OpenAlex
W2140288892
Cited by
566
References
32
FWCI
7.29
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells. https://app.cochat.ai/papers/10.1084/jem.188.12.2375
The paper
Zamai, L., Ahmad, M., Bennett, I. M., Azzoni, L., Alnemri, E. S., & Perussia, B. (1998). Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.12.2375

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.