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Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis
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Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1β and its antagonist, IL-1Ra (IL-1 receptor agonist), are strongly induced by M. tuberculosis and are encoded by polymorphic genes. The induction of both IL-1Ra mRNA and secreted protein by M. tuberculosis in IL-1Ra allele A2–positive (IL-1Ra A2+) healthy subjects was 1.9-fold higher than in IL-1Ra A2− subjects. The M. tuberculosis–induced expression of mRNA for IL-1β was higher in subjects of the IL-1β (+3953) A1+ haplotype (P = 0.04). The molar ratio of IL-1Ra/IL-1β induced by M. tuberculosis was markedly higher in IL-1Ra A2+ individuals (P < 0.05), with minor overlap between the groups, reflecting linkage between the IL-1Ra A2 and IL-1β (+3953) A2 alleles. In M. tuberculosis–stimulated peripheral blood mononuclear cells, the addition of IL-4 increased IL-1Ra secretion, whereas interferon γ increased and IL-10 decreased IL-1β production, indicative of a differential influence on the IL-1Ra/IL-1β ratio by cytokines. In a study of 114 healthy purified protein derivative–reactive subjects and 89 patients with tuberculosis, the frequency of allelic variants at two positions (−511 and +3953) in the IL-1β and IL-1Ra genes did not differ between the groups. However, the proinflammatory IL-1Ra A2−/IL-1β (+3953) A1+ haplotype was unevenly distributed, being more common in patients with tuberculous pleurisy (92%) in comparison with healthy M. tuberculosis–sensitized control subjects or patients with other disease forms (57%, P = 0.028 and 56%, P = 0.024, respectively). Furthermore, the IL-1Ra A2+ haplotype was associated with a reduced Mantoux response to purified protein derivative of M. tuberculosis: 60% of tuberculin-nonreactive patients were of this type. Thus, the polymorphism at the IL-1 locus influences the cytokine response and may be a determinant of delayed-type hypersensitivity and disease expression in human tuberculosis.
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“and human polymorphisms of IL-1 genes were associated with susceptibility to tuberculosis (99).”
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Kindler, V., Sappino, A., Grau, G. E., Piguet, P., & VASSALLI, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,239
A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection
Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., & Levin, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352602 · Cited by 1,198
INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
Arend, W. P., Malyak, M., Guthridge, C. J., & Gabay, C. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.27 · Cited by 1,071
Sreevatsan, S., Pan, X., Stockbauer, K. E., Connell, N. D., Kreiswirth, B. N., Whittam, T. S., & Musser, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9869 · Cited by 1,035
Tuberculosis: Pathogenesis, Protection and Control
(1996) · Nature Medicine · doi:10.1038/nm0296-244b · Cited by 977
Pociot, F., Mølvig, J., Wogensen, L., Worsaae, H., & Nerup, J. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01480.x · Cited by 921
Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection
Jouanguy, E., Altare, F., Lamhamedi‐Cherradi, S., Revy, P., Emile, J., Newport, M. J., Levin, M., Blanche, S., Seboun, E., Fischer, A., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352604 · Cited by 892
Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency
Altare, F., Durandy, A., Lammas, D. A., Emile, J., Lamhamedi‐Cherradi, S., Deist, F. L., Drysdale, P., Jouanguy, E., Döffinger, R., Bernaudin, F., et al. (1998) · Science · doi:10.1126/science.280.5368.1432 · Cited by 843
Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients
de Jong, R., Altare, F., Haagen, I.-A., Elferink, D. G., de Boer, T., Vriesman, P. J. C. V. B., Kabel, P. J., Draaisma, J. M. T., van Dissel, J. T., Kroon, F. P., et al. (1998) · Science · doi:10.1126/science.280.5368.1435 · Cited by 819
Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans
Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Whittle, H. C., & Hill, A. V. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381002 · Cited by 738
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Items 101–200 of 295
Wilkinson, R. J., DesJardin, L. E., Islam, N., Gibson, B. M., Kanost, R. A., Wilkinson, K. A., Poelman, D., Eisenach, K. D., & Toossi, Z. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02280.x · Cited by 52
Self-citationHistorical Intensity of Natural Selection for Resistance to Tuberculosis
Lipsitch, M., & Sousa, A. O. (2002) · Genetics · doi:10.1093/genetics/161.4.1599 · Cited by 51
Lee, K.-M., Park, S. K., Hamajima, N., Tajima, K., Choi, J., Noh, D., Ahn, S.-H., Yoo, K., Hirvonen, A., & Kang, D. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9079-6 · Cited by 51
Interferon‐γ Receptor‐1 Gene Polymorphism in Tuberculosis Patients from Croatia
Fraser, D. A., Bulat-Kardum, L., Knežević, J., Babarovic, P., Mataković-Mileusnić, N., Dellacasagrande, J., Matanić, D., Pavelić, K., Beg-Zec, Z., & Dembić, Z. (2003) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2003.01253.x · Cited by 51
Vamvakopoulos, J. E., Taylor, C. J., Morris-Stiff, G., Green, C. J., & Metcalfe, S. M. (2002) · European Journal of Immunogenetics · doi:10.1046/j.1365-2370.2002.00319.x · Cited by 51
Dwivedi, V. P., Bhattacharya, D., Chatterjee, S., Prasad, D. V. R., Chattopadhyay, D., Kaer, L. V., Bishai, W. R., & Das, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375154 · Cited by 49
Role of cytokines and other factors involved in theMycobacterium tuberculosisinfection
Romero-Adrián, T. B. (2015) · World Journal of Immunology · doi:10.5411/wji.v5.i1.16 · Cited by 51
Minton, E. J., Smillie, D., Smith, P. G., Shipley, S. J., McKendrick, M. W., Gleeson, D. C., Underwood, J. C. E., Cannings, C., & Wilson, A. G. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.11.001 · Cited by 49
Jaber, B. L., Pereira, B. J. G., Bonventre, J. V., & Balakrishnan, V. S. (2004) · Kidney International · doi:10.1111/j.1523-1755.2005.00051.x · Cited by 48
Seno, H., Satoh, K., Tsuji, S., Shiratsuchi, T., Harada, Y., Hamajima, N., Sugano, K., Kawano, S., & Chiba, T. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04934.x · Cited by 48
Kipp, A. M., Stout, J. E., HAMILTON, C. D., & Rie, A. V. (2008) · BMC Public Health · doi:10.1186/1471-2458-8-107 · Cited by 46
Belperio, J. A., DiGiovine, B., Keane, M. P., Burdick, M. D., Xue, Y., Ross, D. J., Lynch, J. P., Kunkel, S. L., & Strieter, R. M. (2002) · Transplantation · doi:10.1097/00007890-200202270-00020 · Cited by 45
Hu, Z., Shao, M., Chen, Y., Zhou, J.-N., Qian, J., Xu, L., Ma, H., Wang, X., Xu, Y., Li, J., et al. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.05.015 · Cited by 45
Kusuhara, K., Yamamoto, K., Okada, K., Mizuno, Y., & Hara, T. (2007) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2007.00653.x · Cited by 45
Awomoyi, A. A., Charurat, M., Marchant, A., Miller, E. N., Blackwell, J. M., McAdam, K. P. W. J., & Newport, M. J. (2005) · Journal of Endotoxin Research · doi:10.1177/09680519050110050401 · Cited by 43
Stewart, G. R., Wilkinson, K. A., Newton, S. M., Sullivan, S. M., Neyrolles, O., Wain, J. R., Patel, J., Pool, K.-L., Young, D. B., & Wilkinson, R. J. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6831-6837.2005 · Cited by 42
Self-citationHost genome polymorphisms and tuberculosis infection: What we have to say?
Khalilullah, S. A., Harapan, H., Hasan, N. A., Winardi, W., Ichsan, I., & Mulyadi, M. (2013) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2013.12.002 · Cited by 42
Nambu, A., & Nakae, S. (2010) · Allergology International · doi:10.2332/allergolint.10-rai-0190 · Cited by 42
Abhimanyu, A., Mangangcha, I. R., Jha, P., Arora, K., Mukerji, M., Banavaliker, J. N., Brahmachari, V., & Bose, M. (2011) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2011.03.017 · Cited by 41
Mehta, J., & Dutt, A. K. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tnmi7-0018-2016 · Cited by 42
Hasan, N., Yusuf, N., Toossi, Z., & Islam, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.071 · Cited by 40
Self-citationIshizuka, K., Sugimura, K., Homma, T., Matsuzawa, J., Mochizuki, T., Kobayashi, M., Suzuki, K., Otsuka, K., Tashiro, K., Yamaguchi, O., et al. (2001) · Digestion · doi:10.1159/000051906 · Cited by 40
TNF-alpha blockade and tuberculosis: better look before you leap.
Arend, S. M., Breedveld, F. C., & van Dissel, J. T. (2003) · PubMed · Cited by 40
Meenakshi, P., Ramya, S. T., Shruthi, T. N., Lavanya, J., Mohammed, H., Mohammed, S. A., Vijayalakshmi, V., & Sumanlatha, G. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12055 · Cited by 39
Solovieva, S. A., Kämäräinen, O., Hirvonen, A., Hämäläinen, S., Taipale, M., Vehmas, T., Luoma, K., Näkki, A., Riihimäki, H., Ala‐Kokko, L., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081238 · Cited by 39
Geismar, K., Enevold, C., Sørensen, L. K., Gyntelberg, F., Bendtzen, K., Sigurd, B. M., & Holmstrup, P. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070454 · Cited by 39
Lachmandas, E., Thiem, K., van den Heuvel, C., Hijmans, A., de Galan, B. E., Tack, C. J., Netea, M. G., van Crevel, R., & van Diepen, J. A. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3145-y · Cited by 39
Lannes-Vieira, J., Quírico‐Santos, T., Da‐Cruz, A. M., Moraes, M. O., & Kubelka, C. F. (2006) · CRC Press eBooks · doi:10.1201/9781420005325.ch28 · Cited by 39
Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty
Francis, S., Camp, N. J., Burton, A. J., Dewberry, R. M., Gunn, J., Stephens-Lloyd, A., Cumberland, D. C., Gershlick, A., & Crossman, D. C. (2001) · Heart · doi:10.1136/heart.86.3.336 · Cited by 39
Phenotype of CF and the effects of possible modifier genes
Acton, J. D., & Wilmott, R. W. (2001) · Paediatric Respiratory Reviews · doi:10.1053/prrv.2001.0168 · Cited by 39
Vitamin D deficiency and TB disease phenotype
Pareek, M., Innes, J., Sridhar, S., Grass, L., Connell, D. W., Woltmann, G., Wiselka, M. J., Martineau, A. R., Kon, O. M., Dedicoat, M. J., et al. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206617 · Cited by 38
Taype, C. A., Castro, J. C., Accinelli, R. A., Herrera-Velit, P., Shaw, M., & Espinoza, J. R. (2006) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2006.01.002 · Cited by 38
Settin, A., Ismail, A., El-Magd, M. A., Elbaz, R., & Kazamel, A. (2009) · Autoimmunity · doi:10.1080/08916930802292510 · Cited by 37
Lack of an Association between Interleukin-12 Receptor β1 Polymorphisms and Tuberculosis in Koreans
Lee, H. W., Lee, H. S., Kim, D. K., Ko, D. S., Han, S. K., Shim, Y., & Yim, J. (2005) · Respiration · doi:10.1159/000086249 · Cited by 37
Genetics of susceptibility to infectious diseases: tuberculosis and leprosy as examples.
Marquet, S., & Schurr, E. (2001) · PubMed · Cited by 37
Oki, N. O., Motsinger‐Reif, A. A., Antas, P. R. Z., Levy, S., Holland, S. M., & Sterling, T. R. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-28 · Cited by 36
Khara, J. S., Mojsoska, B., Mukherjee, D., Langford, P. R., Robertson, B. D., Jenssen, H., Ee, P. L. R., & Newton, S. M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00417 · Cited by 36
Patwari, P. P., OʼCain, P., Goodman, D. M., Smith, M., Krushkal, J., Liu, C., Somes, G. W., Quasney, M. W., & Dahmer, M. K. (2008) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e31818d32f1 · Cited by 35
Tekin, D., Kayaaltı, Z., Dalgıç, N., Çakır, E., Söylemezoğlu, T., Kutlubay, B. I., & Kılıç, B. A. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181d9932e · Cited by 35
Barton, P. T., Gerber, S., Skupski, D. W., & Witkin, S. S. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.271-274.2003 · Cited by 36
Neto, A. C., Rasmussen, L. T., de Lábio, R. W., de Queiroz, V. F., Smith, M. D. A. C., Viani, G. A., & Payão, S. L. M. (2014) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1186/1678-9199-20-17 · Cited by 34
Togun, T. O., Hoggart, C., Agbla, S. C., Gomez, M. P., Egere, U., Sillah, A. K., Saidy, B., Mendy, F. S., Pai, M., & Kampmann, B. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102909 · Cited by 35
Cytokine gene polymorphisms in Turkish patients with inflammatory bowel disease
Çelik, Y., Dağlı, Ü., Kiliç, M. Y., Törüner, M., Özen, S. C., Özkan, M., Soykan, İ., Çetınkaya, H., Ülker, A., Özden, A., et al. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500349523 · Cited by 34
Kaijzel, E. L., van Dongen, H., Bakker, A. M., Breedveld, F. C., Huizinga, T. W. J., & Verweij, C. L. (2002) · Tissue Antigens · doi:10.1034/j.1399-0039.2002.590208.x · Cited by 34
Immunoendocrine Alterations during Human Tuberculosis as an Integrated View of Disease Pathology
Bottasso, O. A., Bay, M. L., Besedovsky, H. O., & del Rey, A. (2009) · NeuroImmunoModulation · doi:10.1159/000180261 · Cited by 33
Human Genetics of Common Mycobacterial Infections
Remus, N., Alcaïs, A., & Abel, L. (2003) · Immunologic Research · doi:10.1385/ir:28:2:109 · Cited by 33
Gene polymorphisms of IL-6−174 G/C and IL-1Ra VNTR in asthmatic children
Settin, A., Zedan, M. M. E., Farag, M., Regal, M. E. E., & Osman, E. (2008) · The Indian Journal of Pediatrics · doi:10.1007/s12098-008-0161-z · Cited by 32
Shen, X., Zhang, J., Yan, Y., Yang, Y., Fu, G., & Pu, Y. (2009) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390902841599 · Cited by 31
Troost, E. G. C., Hold, G. L., Smith, M. G., Chow, W., Rbkin, C. S., McColl, K. E. L., & El-Omar, E. M. (2003) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2003/397060 · Cited by 32
Candiotti, K. A., Yang, Z., Morris, R., Yang, J., Crescimone, N. A., Sanchez, G. C., Bird, V. G., Leveillee, R. J., Rodriguez, Y. F., Liu, H., et al. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318216e9cb · Cited by 30
HLA class II alleles as markers of tuberculosis susceptibility and resistance
Duarte, R., Carvalho, C., Pereira, C., Bettencourt, A., Carvalho, A., Villar, M., Domingos, A. C., Barros, H., Marqués, J., Costa, P., et al. (2011) · Revista Portuguesa de Pneumologia · doi:10.1016/s0873-2159(11)70005-8 · Cited by 30
Genetic Susceptibility to Tuberculosis
Malik, S., & Schurr, E. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.153 · Cited by 29
Hsieh, Y., Chang, C.-C., Tsai, C., Lin, C., & Tsai, F. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.1541 · Cited by 29
Yang, D., & Kong, Y. (2015) · Frontiers in Biology · doi:10.1007/s11515-015-1358-y · Cited by 28
Murillo, L. S. (2003) · Human Reproduction · doi:10.1093/humrep/deg436 · Cited by 28
Hsieh, Y., Chang, C.-C., Tsai, F., Wu, J.-Y., Shi, Y.-R., Tsai, H.-D., & Tsai, C. (2001) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1016653127262 · Cited by 28
Interleukin 1 and Chronic Rejection: Possible Genetic Links in Human Heart Allografts
Vamvakopoulos, J. E., Taylor, C. J., Green, C. J., McNeil, K., Wallwork, J. L., Goodman, R. S., & Metcalfe, S. M. (2002) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2002.020113.x · Cited by 27
Cassidy, J. P., & Martineau, A. R. (2014) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2014.08.001 · Cited by 26
The extrapulmonary dissemination of tuberculosis
Webster, A. S., & Shandera, W. X. (2014) · International Journal of Mycobacteriology · doi:10.1016/j.ijmyco.2014.01.003 · Cited by 26
Maruyama, Y., Nordfors, L., Stenvinkel, P., Heimbürger, O., Barany, P. F., Pecoits‐Filho, R., Axelsson, J., Hoff, C. M., Holmes, C. J., Schalling, M., et al. (2005) · Blood Purification · doi:10.1159/000087196 · Cited by 25
Wu, Y., Yang, X., Wang, X., Qiu, M., You, Y.-Z., Zhang, Z., Zhu, S., Xu, L., & Tang, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066944 · Cited by 25
The Existence of Gender Difference in IL-1Ra Gene Polymorphism
Bessler, H., Osovsky, M., Beilin, B., Alcalay, Y., & Sirota, L. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0029 · Cited by 25
Ray, K. K., Camp, N. J., Bennett, C. E., Francis, S., & Crossman, D. C. (2002) · Clinical Science · doi:10.1042/cs1030303 · Cited by 25
Nishimura, M., Matsuoka, M., Maeda, M., Mizuta, I., Mita, S., Uchino, M., Matsui, M., Kuroda, Y., Kawakami, H., Kaji, R., et al. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00419-6 · Cited by 25
Genetics of susceptibility to tuberculosis in humans
Newport, M. J., & Nejentsev, S. (2004) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2004.707 · Cited by 25
Moreira, J. D., Iakhiaev, A. V., Vankayalapati, R., Jung, B., & Samten, B. (2022) · iScience · doi:10.1016/j.isci.2022.104799 · Cited by 24
Liu, S., Jia, H., Hou, S., Xin, T., Guo, X., Zhang, G., Gao, X., Li, M., Zhu, W., & Zhu, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-20433-x · Cited by 23
Organization of the human interleukin-1 receptor antagonist gene IL1HY1
Mulero, J. J., Nelken, S. T., & Ford, J. E. (2000) · Immunogenetics · doi:10.1007/s002510050640 · Cited by 24
Manchanda, P. K., Bid, H. K., Kumar, A., & Mittal, R. D. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.01.004 · Cited by 24
Mao, X., Ke, Z., Liu, S., Tang, B., Wang, J., Huang, H., & Chen, S. (2015) · Gene · doi:10.1016/j.gene.2015.07.025 · Cited by 23
Interleukin-1 gene cluster polymorphisms in cerebral infarction
Um, J. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00183-2 · Cited by 23
Serum levels of interleukin-1 receptor antagonist (IL-1ra) in thyroid cancer patients
Niedżwiecki, S., Stępień, T., Kuzdak, K., Stepien, H., Krupiński, R., Seehofer, D., Rayes, N., & Ulrich, F. (2007) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-007-0251-9 · Cited by 22
Immunity to intracellular pathogens as a complex genetic trait
Kramnik, I. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00295-3 · Cited by 23
Genetic susceptibility to pulmonary tuberculosis in Cambodia
Goldfeld, A. E. (2003) · Tuberculosis · doi:10.1016/j.tube.2003.08.007 · Cited by 21
Haverkamp, M. H., Lindeboom, J. A. H., de Visser, A. W., Kremer, D., Kuijpers, T. W., van de Vosse, E., & van Dissel, J. T. (2010) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2010.03.031 · Cited by 21
Hsu, P., Li, C., Tseng, H., Lai, K., Hsu, P., Lo, G., Lo, G., Yeh, J., Ger, L., Hsiao, M., et al. (2004) · Helicobacter · doi:10.1111/j.1083-4389.2004.00277.x · Cited by 21
Host genetics and tuberculosis susceptibility
Selvaraj, P. (2004) · NIRT Institutional Scholarship Repository (National Institute of Research in Tuberculosis) · Cited by 20
Bobosha, K., Schip, J. J. V. D. P.-V., Esquenazi, D., Guimarães, M. M. D. S., Martins, M. V. S. B., Bekele, Y., Fantahun, Y., Aseffa, A., Franken, K. L. M. C., Gismondi, R. C., et al. (2012) · Journal of Tropical Medicine · doi:10.1155/2012/132049 · Cited by 20
Yadav, U., Kumar, P., & Rai, V. (2021) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2021.104871 · Cited by 19
Association between IL-1ra Gene Polymorphism and Premature Delivery
Bessler, H., Osovsky, M., & Sirota, L. (2003) · Neonatology · doi:10.1159/000075578 · Cited by 20
Wilkinson, K. A., Martin, T. D., Reba, S. M., Aung, H. L., Redline, R. W., Boom, W. H., Toossi, Z., & Fulton, S. A. (2000) · Infection and Immunity · doi:10.1128/.68.11.6505-6508.2000 · Cited by 20
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Settin, A., Hassan, H. A., Elbaz, R., & Hassan, T. (2011) · Indian Journal of Dermatology · doi:10.4103/0019-5154.82479 · Cited by 19
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Metadata
- Authors
- Wilkinson, R. J., Patel, P., Llewelyn, M., Hirsch, C. S., Pasvol, G., Snounou, G., Davidson, R. N., & Toossi, Z.
- Affiliations
- Northwick Park Hospital (GB)
- Corresponding author
- Toossi, Zahra
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-06-21
- Volume
- 189
- Issue
- 12
- Pages
- 1863-1874
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2192963
- OpenAlex
- W2156995597
- Cited by
- 295
- References
- 58
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 9
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Funders
- Wellcome Trust
- Imperial College London
- National Institutes of Health
- Medical Research Council
- National Institute of Allergy and Infectious Diseases (AI-18471)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interleukin-1 receptor antagonist, IL-1β, genetic polymorphism, host genetic susceptibility, Mycobacterium tuberculosis, pleural tuberculosis, tuberculin skin test
- MeSH terms
- Cell Division, Genotype, Haplotypes, Humans, Hypersensitivity, Delayed, Interleukin-1, Leukocytes, Mycobacterium tuberculosis, Polymorphism, Genetic, RNA, Messenger, Sialoglycoproteins, Tuberculin, Tuberculosis, Interleukin-4, Interleukin-6, Interleukin-10, Receptors, Interleukin-1, Interleukin 1 Receptor Antagonist Protein
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