The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals
Open accessAbstract
We describe here a new subset of T cells, found in humans, mice, and cattle. These cells bear a canonical T cell receptor (TCR) α chain containing hAV7S2 and AJ33 in humans and the homologous AV19-AJ33 in mice and cattle with a CDR3 of constant length. These T cells are CD4−CD8− double-negative (DN) T cells in the three species and also CD8αα in humans. In humans, their frequency was ∼1/10 in DN, 1/50 in CD8α+, and 1/6,000 in CD4+ lymphocytes, and they display an activated/memory phenotype (CD45RAloCD45RO+). They preferentially use hBV2S1 and hBV13 segments and have an oligoclonal Vβ repertoire suggesting peripheral expansions. These cells were present in major histocompatibility complex (MHC) class II– and transporter associated with antigen processing (TAP)-deficient humans and mice and also in classical MHC class I– and CD1-deficient mice but were absent from β2-microglobulin–deficient mice, indicating their probable selection by a nonclassical MHC class Ib molecule distinct from CD1. The conservation between mammalian species, the abundance, and the unique selection pattern suggest an important role for cells using this novel canonical TCR α chain.
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CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
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Self-citationRequirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
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Treiner, E., Duban, L., Bahram, S., Radosavljevic, M., Wanner, V., Tilloy, F., Affaticati, P., Gilfillan, S., & Lantz, O. (2003) · Nature · doi:10.1038/nature01433 · Cited by 1,139
Self-citationAntimicrobial activity of mucosal-associated invariant T cells
Le Bourhis, L., Martin, E., Péguillet, I., Guihot, A., Froux, N., Coré, M., Lévy, E., Dusseaux, M., Meyssonnier, V., Premel, V., et al. (2010) · Nature Immunology · doi:10.1038/ni.1890 · Cited by 936
Self-citationUssher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343509 · Cited by 543
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Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Metadata
- Authors
- Tilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., & Lantz, O.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-06-21
- Volume
- 189
- Issue
- 12
- Pages
- 1907-1921
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1919305622
- Cited by
- 615
- References
- 53
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., & Lantz, O. (1999). An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.12.1907
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
