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Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Abstract
A lymphocyte subpopulation, the V α 14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the V α 14 and J α 281 gene segments. Mice with a deletion of the J α 281 gene segment were found to exclusively lack this subpopulation. The V α 14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, V α 14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.
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Citations
Cited by
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M., Langford, T. K. A., Bucks, C., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 1,938
Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4647 · Cited by 854
NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D. D., Carbone, D. P., Paul, W. E., & Berzofsky, J. A. (2000) · Nature Immunology · doi:10.1038/82771 · Cited by 699
Hepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Interleukin-12: Biological Properties and Clinical Application
Del Vecchio, M., Bajetta, E., Canova, S., Lotze, M. T., Wesa, A., Parmiani, G., & Anichini, A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0776 · Cited by 601
Metadata
- Authors
- Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M.
- Venue
- Science
- Published
- 1997-11-28
- Volume
- 278
- Issue
- 5343
- Pages
- 1623-1626
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995529916
- Cited by
- 1,237
- References
- 0
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997). Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors. Science. https://doi.org/10.1126/science.278.5343.1623
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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