The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system, neurons are considered the major cellular source of BDNF. We demonstrate here that in addition, activated human T cells, B cells, and monocytes secrete bioactive BDNF in vitro. Notably, in T helper (Th)1- and Th2-type CD4+ T cell lines specific for myelin autoantigens such as myelin basic protein or myelin oligodendrocyte glycoprotein, BDNF production is increased upon antigen stimulation. The BDNF secreted by immune cells is bioactive, as it supports neuronal survival in vitro. Using anti-BDNF monoclonal antibody and polyclonal antiserum, BDNF immunoreactivity is demonstrable in inflammatory infiltrates in the brain of patients with acute disseminated encephalitis and multiple sclerosis. The results raise the possibility that in the nervous system, inflammatory infiltrates have a neuroprotective effect, which may limit the success of nonselective immunotherapies.
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Cites
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Cited by
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
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Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
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Metadata
- Authors
- Kerschensteiner, M., Gallmeier, E., Behrens, L., Leal, V. V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R.-L., Bartke, I., Stadelmann, C., Lassmann, H., Wekerle, H., & Hohlfeld, R.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-03-01
- Volume
- 189
- Issue
- 5
- Pages
- 865-870
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2120819751
- Cited by
- 1,019
- References
- 26
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kerschensteiner, M., Gallmeier, E., Behrens, L., Leal, V. V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R.-L., Bartke, I., Stadelmann, C., Lassmann, H., Wekerle, H., & Hohlfeld, R. (1999). Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation? The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.5.865
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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