The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.
Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood
Open accessAbstract
To study telomere length dynamics in hematopoietic cells with age, we analyzed the average length of telomere repeat sequences in diverse populations of nucleated blood cells. More than 500 individuals ranging in age from 0 to 90 yr, including 36 pairs of monozygous and dizygotic twins, were analyzed using quantitative fluorescence in situ hybridization and flow cytometry. Granulocytes and naive T cells showed a parallel biphasic decline in telomere length with age that most likely reflected accumulated cell divisions in the common precursors of both cell types: hematopoietic stem cells. Telomere loss was very rapid in the first year, and continued for more than eight decades at a 30-fold lower rate. Memory T cells also showed an initial rapid decline in telomere length with age. However, in contrast to naive T cells, this decline continued for several years, and in older individuals lymphocytes typically had shorter telomeres than did granulocytes. Our findings point to a dramatic decline in stem cell turnover in early childhood and support the notion that cell divisions in hematopoietic stem cells and T cells result in loss of telomeric DNA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, TL naive T cells are longer than that of memory T cells [224].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [224]
In the citing paper
“T‐cell telomere length declines with age (Rufer et al, 1999), suggesting they have undergone replicative senescence from repetitive divisions.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Rufer et al, 1999
In the citing paper
“When examining telomere measurements within a mixed cell population, it is important to note that this is a surrogate marker of the mean in a heterogeneous cell population and that telomere length is mosaic, reflecting the telomere length regulation and replicative history of each cell type51,52.”
From The telomere syndromes (2012) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Draper, N. R., & Smith, H. (1998) · Wiley series in probability and statistics · doi:10.1002/9781118625590 · Cited by 5,086
Gunst, R. F., Draper, N. R., & Smith, H. C. (1999) · Technometrics · doi:10.2307/1270576 · Cited by 4,071
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650
Phenotypic and functional separation of memory and effector human CD8+ T cells
Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132
Self-citationHeterogeneity in telomere length of human chromosomes
Lansdorp, P. M. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.5.685 · Cited by 886
Self-citationTurnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Flagged first, then by citations
2 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Rosendaal, 1979, Organization of haemopoietic stem cellsthe generation-age hypothesis, Cell Tissue Kinet., 12, 17
Cited by
Sorted by citations
Items 401–500 of 709
Iskandar, M., Barbero, M. X., Jaber, M. T., Chen, R., Gomez-Guevara, R., Cruz, E., & Westerheide, S. D. (2025) · Cancers · doi:10.3390/cancers17020257 · Cited by 30
Wang, T., Jia, Z., Li, S., Li, Y., Tingting, Y., Lu, T., & Shi, Y. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02114-8 · Cited by 22
Wei, D., Jiang, Y., Cheng, J., Wang, H., Sha, K., & Zhao, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1023991 · Cited by 21
Telomere length and age in pinnipeds: The endangered Australian sea lion as a case study
Izzo, C., Hamer, D. J., Bertozzi, T., Donnellan, S. C., & Gillanders, B. M. (2011) · Marine Mammal Science · doi:10.1111/j.1748-7692.2010.00450.x · Cited by 21
Predicting CD4 T‐Cell Reconstitution Following Pediatric Hematopoietic Stem Cell Transplantation
Hoare, R. L., Veys, P. A., Klein, N. J., Callard, R. E., & Standing, J. F. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.621 · Cited by 21
Dysfunctional telomeres and dyskeratosis congenita
Bessler, M., Du, H., Gu, B., & Mason, P. J. (2007) · Haematologica · doi:10.3324/haematol.11221 · Cited by 21
Human Thymus Exports Naive CD8 T Cells That Can Home to Nonlymphoid Tissues
Zippelius, A., Bioley, G., Gal, F. L., Rufer, N., Brandes, M., Batard, P., Smedt, M. D., Plum, J. R., Speiser, D. E., Cerottini, J., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2773 · Cited by 21
Self-citationMemory Functions and Death Proneness in Three CD4+CD45RO+ Human T Cell Subsets
Ohara, T., Koyama, K., Kusunoki, Y., Hayashi, T., Tsuyama, N., Kubo, Y., & Kyoizumi, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.39 · Cited by 21
A kinetic model of telomere shortening in infants and adults
Sidorov, I. A., Gee, D., & Dimitrov, D. S. (2003) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2003.08.009 · Cited by 21
Hiding in Plain Sight: Virtually Unrecognizable Memory Phenotype CD8+ T cells
Thiele, D., Gruta, N. L. L., Nguyen, A., & Hussain, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228626 · Cited by 23
Wojcicki, J. M., Medrano, R., Lin, J., & Epel, E. S. (2017) · Childhood Obesity · doi:10.1089/chi.2017.0159 · Cited by 21
Nuclear Flow FISH: Isolation of cell nuclei improves the determination of telomere lengths
Wieser, M., Stadler, G., Böhm, E., Borth, N., Katinger, H. W. D., Grillari, J., & Voglauer, R. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.013 · Cited by 21
Murillo-Ortiz, B. O., Albarrán-Tamayo, F., López-Briones, S., Martı́nez-Garza, S., Benı́tez-Bribiesca, L., & Arenas-Aranda, D. J. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-99 · Cited by 20
Stem cell function and maintenance – ends that matter: Role of telomeres and telomerase
Saeed, H., & Iqtedar, M. (2013) · Journal of Biosciences · doi:10.1007/s12038-013-9346-3 · Cited by 19
Neuber, K., Schmidt, S., & Mensch, A. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01640.x · Cited by 19
Increased Telomere Attrition After Renal Transplantation—Impact of Antimetabolite Therapy
Luttropp, K., Nordfors, L., McGuinness, D., Wennberg, L. M., Curley, H., Quasim, T., Genberg, H., Sandberg, J. T., Sönnerborg, I., Schalling, M., et al. (2016) · Transplantation Direct · doi:10.1097/txd.0000000000000629 · Cited by 19
The Hayflick Limit and Age-Related Adaptive Immune Deficiency
Gill, Z., Nieuwoudt, M., & Ndifon, W. O. (2017) · Gerontology · doi:10.1159/000478091 · Cited by 19
Telomeres, Telomerase, Stress, and Aging
Lin, J., Epel, E. S., & Blackburn, E. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002065 · Cited by 19
Huang, J., Xie, C., Niu, Z., He, L., & Li, J. (2020) · Helicobacter · doi:10.1111/hel.12760 · Cited by 17
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18
Self-citationAccelerated telomere shortening in rheumatic diseases: cause or consequence?
Dehbi, A. Z., Radstake, T. R. D. J., & Broen, J. C. A. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.850031 · Cited by 18
Udroiu, I., & Sgura, A. (2019) · Biogerontology · doi:10.1007/s10522-019-09804-7 · Cited by 18
Baskind, M. J., Hawkins, J., Heyman, M. B., & Wojcicki, J. M. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.11.025 · Cited by 18
A comparison of normal and leukemic stem cell biology in Chronic Myeloid Leukemia
Jørgensen, H. G., & Holyoake, T. L. (2001) · Hematological Oncology · doi:10.1002/hon.667 · Cited by 18
Rufer, N., Reichenbach, P., & Romero, P. J. (2004) · Humana Press eBooks · doi:10.1385/1-59259-862-5:265 · Cited by 18
Self-citationAnatomy and physiology of hematopoiesis
Eaves, C. J., & Eaves, A. C. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511471001.005 · Cited by 19
Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics
Melicher, D., Buzás, E. I., & Falus, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1991-2 · Cited by 17
Modelling hematopoiesis in health and disease
Peixoto, D., Dingli, D., & Pacheco, J. M. (2010) · Mathematical and Computer Modelling · doi:10.1016/j.mcm.2010.04.013 · Cited by 17
Inferring relative numbers of human leucocyte genome replications
Chu, M. W., Siegmund, K. D., Hao, Q., Crooks, G. M., Tavaré, S., & Shibata, D. K. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07142.x · Cited by 17
Telomeres and telomerase in normal and malignant B‐cells
Lobetti‐Bodoni, C., Bernocco, E., Genuardi, E., Boccadoro, M., & Ladetto, M. (2010) · Hematological Oncology · doi:10.1002/hon.937 · Cited by 17
Stockklausner, C., Raffel, S., Klermund, J., Bandapalli, O. R., Beier, F., Brümmendorf, T. H., Bürger, F., Sauer, S. W., Hoffmann, G. F., Lorenz, H., et al. (2015) · Aging · doi:10.18632/aging.100835 · Cited by 16
Self-citationThe Use of In Vitro Systems to Assess Cancer Mechanisms and the Carcinogenic Potential of Chemicals
Breheny, D., Oke, O., & Faux, S. P. (2011) · Alternatives to Laboratory Animals · doi:10.1177/026119291103900301 · Cited by 17
Xu, S., Kim, S., Chen, I. S. Y., & Chou, T. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006489 · Cited by 15
A Cross-Sectional Study of Ageing and Cardiovascular Function over the Baboon Lifespan
Yeung, K. R., Chiu, C. L., Pears, S., Heffernan, S. J., Makris, A., Hennessy, A., & Lind, J. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159576 · Cited by 16
Association between Telomere Length and Pediatric Obesity: A Systematic Review
Raftopoulou, C., Paltoglou, G., & Charmandari, E. (2022) · Nutrients · doi:10.3390/nu14061244 · Cited by 16
Куликова, Е. В., Васильевич, К. В., Shevchenko, J. A., Облеухова, И. А., Khrapov, E. A., Boyarskikh, U. A., Филипенко, М. Л., Шорохов, Р. В., Yakushenko, V. K., Sokolov, A. V., et al. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12311 · Cited by 16
Potter, A., & Wener, M. H. (2005) · Cytometry Part A · doi:10.1002/cyto.a.20181 · Cited by 16
Evolutionary Dynamics of Chronic Myeloid Leukemia
Dingli, D., Traulsen, A., Lenaerts, T., & Pacheco, J. M. (2010) · Genes & Cancer · doi:10.1177/1947601910371122 · Cited by 18
Telomerase‐based therapies in haematological malignancies
Rafat, A., Asl, K. D., Mazloumi, Z., Movassaghpour, A. A., Farahzadi, R., Nejati, B., & Charoudeh, H. N. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3687 · Cited by 18
Green fluorescent protein as a novel tool to measure apoptosis and necrosis
Strebel, A., Harr, T., Bachmann, F., Wernli, M., & Erb, P. (2001) · Cytometry · doi:10.1002/1097-0320(20010201)43:2 · Cited by 70
Tometten, M., Beier, F., Kirschner, M., Schumacher, Y., Walter, J., Vieri, M., Kricheldorf, K., Röth, A., Platzbecker, U., Radsak, M. P., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024014632 · Cited by 15
Self-citationCD57 T cells associated with immunosenescence in adults living with HIV or AIDS
Júnior, E. E., Gubert, V. T., Jacob, C. M. B., Puga, M. A. M., Gouveia, C. G., Sichinel, Â. H., & Tozetti, I. A. (2023) · Immunology · doi:10.1111/imm.13707 · Cited by 15
Wolf, S. E., Hastings, W. J., Ye, Q., Etzel, L. C., Apsley, A. T., Chiaro, C. R., Heim, C. C., Heller, T., Noll, J. G., Schreier, H. M. C., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0290918 · Cited by 15
Schilling, G., Penas, E. M. M., Janjetovic, S., Oliveira‐Ferrer, L., Braig, M., Behrmann, P., Bokemeyer, C., & Dierlamm, J. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.10.009 · Cited by 15
Can telomere length predict cardiovascular risk?
Spyridopoulos, I., & Dimmeler, S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60042-7 · Cited by 15
Stem Cells and Regenerative Medicine - A Review
Ramakrishna, V., Janardhan, P., & Sudarsanareddy, L. (2011) · Annual Research & Review in Biology · Cited by 15
Dynamics of haemopoiesis across mammals
Dingli, D., Traulsen, A., & Pacheco, J. M. (2008) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2008.0506 · Cited by 15
Pavlaki, K. I., Kastrinaki, M.-C., Klontzas, M., Velegraki, M., Mavroudi, I., & Papadaki, H. Α. (2011) · Haematologica · doi:10.3324/haematol.2011.053983 · Cited by 14
Reproductive fitness advantage of BCR–ABL expressing leukemia cells
Traulsen, A., Pacheco, J. M., & Dingli, D. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.01.020 · Cited by 14
Widmann, T., Kneer, H., König, J., Herrmann, M., & Pfreundschuh, M. G. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.08.028 · Cited by 14
Hartmann, U., Balabanov, S., Ziegler, P., Fellenberg, J., van der Kuip, H., Duyster, J., Lipp, H., Bokemeyer, C., Kanz, L., & Brümmendorf, T. H. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.02.002 · Cited by 14
Self-citationBone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential
Kohutek, Z. A., Caslin, H. L., Fehrenbach, D. J., Heimlich, J. B., Brown, J. D., Madhur, M. S., Ferrell, P. B., & Doran, A. C. (2025) · Circulation Research · doi:10.1161/circresaha.124.323778 · Cited by 18
Boyle, C., Lansdorp, P. M., & Edelstein‐Keshet, L. (2023) · iScience · doi:10.1016/j.isci.2023.107053 · Cited by 18
Self-citationT-cell lymphocytes’ aging clock: telomeres, telomerase and aging
Chebly, A., Khalil, C., Kuzyk, A. C., Beylot-Barry, M., & Chevret, E. (2023) · Biogerontology · doi:10.1007/s10522-023-10075-6 · Cited by 13
Stabilization of telomeres in nonlinear models of proliferating cell lines
Dyson, J., Sánchez, E., Villella-Bressan, R., & Webb, G. F. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.08.023 · Cited by 13
Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH
Sharifi‐Sanjani, M., Meeker, A. K., & Mourkioti, F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.082 · Cited by 13
Barraclough, J., Skilton, M. R., Garden, F. L., Toelle, B. G., Marks, G. B., & Celermajer, D. S. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.12.065 · Cited by 13
Senescence of Hematopoietic Stem Cells and Bone Marrow Failure
Chen, J. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05094 · Cited by 13
Influence of telomere length on short-term recovery after allogeneic stem cell transplantation
Widmann, T., Willmann, B., Pfreundschuh, M. G., & Beelen, D. W. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.05.019 · Cited by 14
Télomérase, élixir de jouvence des cellules humaines ?
Rufer, N., & Nabholz, M. (2003) · médecine/sciences · doi:10.1051/medsci/2003193345 · Cited by 13
Self-citationRolles, B., Gorgulho, J., Tometten, M., Roderburg, C., Vieri, M., Abels, A., Vucur, M., Heymann, F., Tacke, F., Brümmendorf, T. H., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.729207 · Cited by 12
Self-citationTelomere length and age-dependent telomere attrition: the blood-and-muscle model
Chahine, M. N., Toupance, S., El-Hakim, S., Labat, C., Gautier, S., Moussallem, T., Yared, P., Asmar, R. G., & Bénétos, A. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0582 · Cited by 12
Association between leukocyte telomere length and sex by quantile regression analysis
Gutierrez‐Rodrigues, F., Alves‐Paiva, R. M., Scatena, N. F., Martínez, E. Z., Scheucher, P. S., & Calado, R. T. (2021) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2020.12.005 · Cited by 12
Telomeres, X‐Inactivation Ratios, and Hematopoietic Stem Cell Transplantation in Humans: A Review
Thornley, I., & Freedman, M. H. (2002) · Stem Cells · doi:10.1634/stemcells.20-3-198 · Cited by 12
Praengam, K., Tuntipopipat, S., Muangnoi, C., Jangwangkorn, C., & Piamkulvanich, O. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.3851 · Cited by 12
Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer
Loukopoulou, C., Νikolouzakis, Τ. Κ., Koliarakis, I., Vakonaki, E., & Tsiaoussis, J. (2024) · Cancers · doi:10.3390/cancers16193370 · Cited by 15
A Self-Activating IL-15 Chimeric Cytokine Receptor to Empower Cancer Immunotherapy
Chen, S., Yang, L., Xia, B., Zhu, H., Piao, Z.-H., & Jounaïdi, Y. (2024) · ImmunoTargets and Therapy · doi:10.2147/itt.s490498 · Cited by 11
T cell aging and exhaustion: Mechanisms and clinical implications
Zhang, W., Kong, D., Zhang, X., Hu, L., Nian, Y., & Shen, Z. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110486 · Cited by 13
Nguyen, L. N. T., Nguyen, L. N., Zhao, J., Schank, M., Dang, X., Cao, D., Khanal, S., Wu, X. Y., Zhang, Y., Zhang, J., et al. (2022) · Journal of Cell Science · doi:10.1242/jcs.259481 · Cited by 11
Zole, E., & Ranka, R. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2019.04.007 · Cited by 12
Lobachevsky, P. N., & Radford, I. R. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00395.x · Cited by 11
The importance of the telomere and telomerase system in hematological malignancies
Ram, R., Uziel, O., & Lahav, M. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500125853 · Cited by 11
Does telomere shortening count?
Engelhardt, M. M., & Finke, J. (2001) · Blood · doi:10.1182/blood.v98.3.888 · Cited by 11
Distinct senescence mechanisms restrain progression of dysplastic nevi
Lorbeer, F. K., Rieser, G., Goel, A., Wang, M., Oh, A., Yeh, I., Bastian, B. C., & Hockemeyer, D. F. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae041 · Cited by 10
Rengelshausen, J., Randerath, I. E., Schettgen, T., Esser, A., Kaifie, A., Lang, J., Kraus, T., & Ziegler, P. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03578-1 · Cited by 14
Muzumdar, R. H., & Atzmo, G. (2012) · InTech eBooks · doi:10.5772/53227 · Cited by 11
Inferring average generation via division-linked labeling
Weber, T. S., Perié, L., & Duffy, K. R. (2016) · Journal of Mathematical Biology · doi:10.1007/s00285-015-0963-3 · Cited by 10
Telomere-based therapy for immunosenescence
Lord, J. M. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02170-1 · Cited by 10
Inferring average generation via division-linked labeling
Weber, T. S., Perié, L., & Duffy, K. R. (2015) · Maynooth University ePrints and eTheses Archive (Maynooth University) · Cited by 10
Zizza, A., Panìco, A., Grassi, T., Recchia, V., Grima, P., Giglio, O. D., & Bagordo, F. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503561 · Cited by 10
Iancu, E. M., Baumgaertner, P., Wieckowski, S., Speiser, D. E., & Rufer, N. (2010) · BioMed Research International · doi:10.1155/2011/452606 · Cited by 10
Self-citationAssociation Between Telomere Shortening and Ageing During Occupational Exposure
Eshkoor, S. A., Jahanshiri, F., Ismail, P., Rahman, S. A., Moin, S., & Adon, M. Y. (2012) · Journal of Medical Biochemistry · doi:10.2478/v10011-012-0005-2 · Cited by 10
Scheding, S., Ersöz, I., Hartmann, U., Bartolvic, K., Balabanov, S., Salama, A., Kanz, L., & Brümmendorf, T. H. (2003) · Transfusion · doi:10.1046/j.1537-2995.2003.00457.x · Cited by 10
Self-citationIsolation and therapeutic potential of human haemopoietic stem cells
Clark, A. D., Jørgensen, H. G., Mountford, J. C., & Holyoake, T. L. (2003) · Cytotechnology · doi:10.1023/a:1024822722285 · Cited by 9
Podestà, M. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200111000-00003 · Cited by 10
Sato, S., Ogawa, Y., Shimizu, E., Asai, K., Okazaki, T., Rusch, R., Hirayama, M., Shimmura, S., Negishi, K., & Tsubota, K. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.03.006 · Cited by 9
Biomarkers for aging of blood – how transferable are they between mice and humans?
Tharmapalan, V., & Wagner, W. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104600 · Cited by 9
Macdonald, D. W., & Newman, C. (2022) · doi:10.1093/oso/9780192845368.001.0001 · Cited by 11
Jia, Q., & Nash, J. F. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_28-2 · Cited by 9
Population mixture model for nonlinear telomere dynamics
Itzkovitz, S., Shlush, L. I., Glück, D., & Skorecki, K. L. (2008) · Physical Review E · doi:10.1103/physreve.78.060902 · Cited by 9
Ancestral telomere shortening: A countdown that will increase mean life span?
Hertzog, R. G. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.01.034 · Cited by 9
Month of Birth and Dementia Late in Life
Doblhammer, G., & Fritze, T. (2015) · KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie · doi:10.1007/s11577-015-0328-3 · Cited by 9
New Approaches to Fluorescence In Situ Hybridization
Murthy, S. K., & Demetrick, D. J. (2006) · Methods in molecular biology · doi:10.1007/978-1-59259-993-6_12 · Cited by 9
Lin, A., Arnold, B. F., Mertens, A., Lin, J., Benjamin‐Chung, J., Ali, S., Hubbard, A., Stewart, C. P., Shoab, A. K., Rahman, M. Z., et al. (2017) · eLife · doi:10.7554/elife.29365 · Cited by 7
Assessment of Telomere Length, Phenotype, and DNA Content
Schmid, I., & Jamieson, B. D. (2004) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy0726s29 · Cited by 9
Sibert, N., Ferreira, M. S. V., Wagner, W., Eipel, M., Dreschers, S., Brümmendorf, T. H., Orlikowsky, T. W., & Beier, F. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9775 · Cited by 9
Self-citationde Fluiter, K. S., Codd, V., Denniff, M. J., Kerkhof, G. F., van Beijsterveldt, I. A. L. P., Breij, L. M., Samani, N. J., Berkeveld, M. A., & Hokken-Koelega, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246400 · Cited by 9
Fukunaga, A., Ishikawa, T., Kishihata, M., Shindo, T., Hori, T., & Uchiyama, T. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2007.06.009 · Cited by 8
Boiret, N., Kanold, J., Bons, J., Rapatel, C., Halle, P., Tournilhac, O., Guilhouard, L., Guérin, J., Travade, P., Deméocq, F., et al. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02604.x · Cited by 9
Replicative Senescence and Cancer
Hornsby, P. J. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23962-6_3 · Cited by 9
Metadata
- Authors
- Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M.
- Affiliations
- aFrom the Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
- bInstitute of Human Genetics, University of Aarhus, 8000 Aarhus, Denmark
- Aarhus University (DK)
- University of Southern Denmark (DK)
- University of British Columbia (CA)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-07-19
- Volume
- 190
- Issue
- 2
- Pages
- 157-168
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2195579
- OpenAlex
- W2064651531
- Cited by
- 709
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 17 · 2023: 21 · 2022: 45 · 2021: 24 · 2020: 17 · 2019: 18 · 2018: 25 · 2017: 21 · 2016: 16 · 2015: 30 · 2014: 21 · 2013: 19 · 2012: 31
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, cc-by-nc-sa)
- IRIS (submittedVersion, cc-by-nc-sa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- National Research Foundation
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Danmarks Grundforskningsfond (PO1-AG08761)
- National Institutes of Health (1r01gm056162-01)
- National Institute on Aging (PO1-AG08761, NIA-PO1-AG08761, P01AG008761)
- National Cancer Institute
- National Institute of General Medical Sciences (GM56162)
- National Institute of Allergy and Infectious Diseases (AI 29524, R21AI029524, R01AI029524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomere length, hematopoietic stem cells, memory T cells, naive T cells, granulocytes, aging, cell division, early childhood, telomere shortening
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Female, Flow Cytometry, Granulocytes, Hematopoietic Stem Cells, Humans, Immunologic Memory, Infant, Infant, Newborn, Male, Middle Aged, Twins, Dizygotic, Twins, Monozygotic, T-Lymphocyte Subsets, Telomere, In Situ Hybridization, Fluorescence, Terminal Repeat Sequences
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
