The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
Open accessAbstract
We have identified platelet glycoprotein (GP) Ibα as a counterreceptor for P-selectin. GP Ibα is a component of the GP Ib-IX-V complex, which mediates platelet adhesion to subendothelium at sites of injury. Cells expressing P-selectin adhered to immobilized GP Ibα, and GP Ibα–expressing cells adhered to and rolled on P-selectin and on histamine-stimulated endothelium in a P-selectin–dependent manner. In like manner, platelets rolled on activated endothelium, a phenomenon inhibited by antibodies to both P-selectin and GP Ibα. Unlike the P-selectin interaction with its leukocyte ligand, PSGL-1 (P-selectin glycoprotein ligand 1), the interaction with GP Ibα required neither calcium nor carbohydrate core-2 branching or α(1,3)-fucosylation. The interaction was inhibited by sulfated proteoglycans and by antibodies against GP Ibα, including one directed at a tyrosine-sulfated region of the polypeptide. Thus, the GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium.
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Platelets in inflammation and thrombosis
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Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0379-5 · Cited by 398
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Metadata
- Authors
- Romo, G. M., Dong, J.-F., Schade, A. J., Gardiner, E. E., Kansas, G. S., Li, C. Q., McIntire, L. V., Berndt, M. C., & López, J. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-09-20
- Volume
- 190
- Issue
- 6
- Pages
- 803-814
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2123695942
- Cited by
- 355
- References
- 38
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Romo, G. M., Dong, J.-F., Schade, A. J., Gardiner, E. E., Kansas, G. S., Li, C. Q., McIntire, L. V., Berndt, M. C., & López, J. A. (1999). The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.190.6.803
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