The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses
Open accessAbstract
We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T1/ST2 in T helper cell type 2 (Th2) responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of T1/ST2-deficient mice with those generated by wild-type mice. Using a primary pulmonary granuloma model, induced with Schistosoma mansoni eggs, we demonstrate that granuloma formation, characterized by eosinophil infiltration, is abrogated in T1/ST2-deficient mice. Furthermore, we clearly demonstrate that in the absence of T1/ST2 expression, the levels of Th2 cytokine production are severely impaired after immunization. Thus, in a secondary pulmonary granuloma model, draining lymph node cells from the T1/ST2-deficient animals produced significantly reduced levels of IL-4 and IL-5, despite developing granulomas of a magnitude similar to those of wild-type mice and comparable antigen-specific immunoglobulin isotype production. These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence.
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Cites
Interleukin-13: Central Mediator of Allergic Asthma
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Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells
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Self-citationImpaired Development of Th2 Cells in IL-13-Deficient Mice
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Cited by
Negative regulation of Toll-like receptor-mediated immune responses
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Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells
Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Lineage commitment in the immune system: the T helper lymphocyte grows up
Glimcher, L. H., & Murphy, K. M. (2000) · Genes & Development · doi:10.1101/gad.14.14.1693 · Cited by 623
Metadata
- Authors
- Townsend, M. J., Fallon, P. G., Matthews, D. J., Jolin, H. E., & McKenzie, A. N. J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-03-20
- Volume
- 191
- Issue
- 6
- Pages
- 1069-1076
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2168082890
- Cited by
- 482
- References
- 28
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Townsend, M. J., Fallon, P. G., Matthews, D. J., Jolin, H. E., & McKenzie, A. N. J. (2000). T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.191.6.1069
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