Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells

The Sequence Alignment/Map format and SAMtools

Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models

Stamatakis, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl446 · Cited by 15,582 · see citing works

Differential expression analysis for sequence count data

Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works

The Pfam Protein Families Database

Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,062 · see citing works

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.

Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668 · see citing works

Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen

Krogh, A., Larsson, B., von Heijne, G., & Sonnhammer, E. L. L. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4315 · Cited by 12,654 · see citing works

Prodigal: prokaryotic gene recognition and translation initiation site identification

Hyatt, D., Chen, G.-L., LoCascio, P. F., Land, M., Larimer, F. W., & Hauser, L. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-119 · Cited by 12,426 · see citing works

Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research

Conesa, A., Götz, S., Garcia-Gomez, J. M., Terol, J., Talón, M., & Robles, M. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti610 · Cited by 11,417 · see citing works

tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence

Lowe, T. M., & Eddy, S. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.955 · Cited by 11,120 · see citing works

SignalP 4.0: discriminating signal peptides from transmembrane regions

Petersen, T. N., Brunak, S., von Heijne, G., & Nielsen, H. (2011) · Nature Methods · doi:10.1038/nmeth.1701 · Cited by 8,847 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

RNAmmer: consistent and rapid annotation of ribosomal RNA genes

Lagesen, K., Hallin, P., Rødland, E., Stærfeldt, H., Rognes, T., & Ussery, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm160 · Cited by 5,965 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

A Genomic Perspective on Protein Families

Tatusov, R. L., Koonin, E. V., & Lipman, D. J. (1997) · Science · doi:10.1126/science.278.5338.631 · Cited by 3,552 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

GenePattern 2.0

Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,035 · see citing works

Reciprocal T _H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,859 · see citing works

The Pfam protein families database

Finn, R. D., Tate, J. G., Mistry, J., Coggill, P. C., Sammut, S., Hotz, H.-R., Ceric, G., Forslund, S. K., Eddy, S. R., Sonnhammer, E. L. L., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm960 · Cited by 1,847 · see citing works

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works

Innate IL-17-producing cells: the sentinels of the immune system

Cua, D. J., & Tato, C. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2800 · Cited by 1,578 · see citing works

A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis

Dillies, M., Rau, A., Aubert, J., Hennequet‐Antier, C., Jeanmougin, M., Servant, N., Keime, C., Marot, G., Castel, D., Estellé, J., et al. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs046 · Cited by 1,281 · see citing works

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

Yang, X. O., Nurieva, R., Martínez, G., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B., Chang, S. H., Schluns, K. S., Watowich, S. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.007 · Cited by 1,129 · see citing works

Peripheral education of the immune system by colonic commensal microbiota

Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034 · see citing works

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

Eberl, G., Marmon, S., Sunshine, M. J., Rennert, P. D., Choi, Y., & Littman, D. R. (2003) · Nature Immunology · doi:10.1038/ni1022 · Cited by 986 · see citing works

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840 · see citing works

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism

Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 675 · see citing works

Natural history and evolutionary principles of gene duplication in fungi

Wapinski, I., Pfeffer, A., Friedman, N., & Regev, A. (2007) · Nature · doi:10.1038/nature06107 · Cited by 614 · see citing works

Induced CD4⁺Foxp3⁺Regulatory T Cells in Immune Tolerance

Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569 · see citing works

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works

TIGRFAMs: a protein family resource for the functional identification of proteins

Haft, D. H. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.41 · Cited by 495 · see citing works

T1/St2-Deficient Mice Demonstrate the Importance of T1/St2 in Developing Primary T Helper Cell Type 2 Responses

Townsend, M. J., Fallon, P. G., Matthews, D. J., Jolin, H. E., & McKenzie, A. N. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.1069 · Cited by 482 · see citing works

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

Sawada, S. (1994) · Cell · doi:10.1016/0092-8674(94)90140-6 · Cited by 436 · see citing works

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

Glaccum, M. B., Stocking, K., Charrier, K., Smith, J., Willis, C., Maliszewski, C., Livingston, D., Peschon, J., & Morrissey, P. (1997) · Journal of Immunology · doi:10.4049/jimmunol.159.7.3364 · Cited by 418 · see citing works

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Cebula, A., Seweryn, M. T., Rempała, G. A., Pabla, S. S., McIndoe, R., Denning, T. L., Bry, L., Kraj, P. J., Kisielow, P., & Ignatowicz, L. (2013) · Nature · doi:10.1038/nature12079 · Cited by 378 · see citing works

Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice

Faith, J. J., Ahern, P. P., Ridaura, V. K., Cheng, J., & Gordon, J. I. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008051 · Cited by 373 · see citing works

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

Awasthi, A., Riol‐Blanco, L., Jäger, A., Korn, T., Pot, C., Galileos, G., Bettelli, E., Kuchroo, V. K., & Oukka, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900732 · Cited by 365 · see citing works

Regulatory T cells in nonlymphoid tissues

Burzyn, D., Benoist, C. O., & Mathis, D. J. (2013) · Nature Immunology · doi:10.1038/ni.2683 · Cited by 342 · see citing works

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C. Y., Wu, C., Baloglu, E., Schmidt, D. R., Ramesh, R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.004 · Cited by 277 · see citing works

Differentiation of regulatory Foxp3 + T cells in the thymic cortex

Liston, A., Nutsch, K., Farr, A. G., Lund, J. M., Rasmussen, J. P., Koni, P. A., & Rudensky, A. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801506105 · Cited by 240 · see citing works

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

Abraham, C., & Cho, J. H. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.051407.123757 · Cited by 169 · see citing works

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

Gonzalez, A., André‐Schmutz, I., Carnaud, C., Mathis, D. J., & Benoist, C. O. (2001) · Nature Immunology · doi:10.1038/ni738 · Cited by 155 · see citing works

Pharmacologic Inhibition of RORγt Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

Skepner, J. E., Ramesh, R., Trocha, M., Schmidt, D. R., Baloglu, E., Lobera, M., Carlson, T. J., Hill, J. A., Orband‐Miller, L. A., Barnes, A. A., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302190 · Cited by 141 · see citing works

Automatic genome-wide reconstruction of phylogenetic gene trees

Wapinski, I. N., Pfeffer, A., Friedman, N., & Regev, A. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm193 · Cited by 136 · see citing works

EFICAz: a comprehensive approach for accurate genome-scale enzyme function inference

Tian, W., Arakaki, A. K., & Skolnick, J. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh956 · Cited by 106 · see citing works

IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells

Du, R., Zhao, H., Fan, Y. L., & Li, H. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ru0114-010rr · Cited by 88 · see citing works

Restricted Microbiota and Absence of Cognate TCR Antigen Leads to an Unbalanced Generation of Th17 Cells

Lochner, M., Berard, M., Sawa, S., Hauer, S., Gaboriau‐Routhiau, V., Fernández, T. D., Snel, J., Bousso, P., Cerf–Bensussan, N., & Eberl, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001723 · Cited by 80 · see citing works

T‐cell selection and intestinal homeostasis

Ai, T. L., Solomon, B. D., & Hsieh, C. (2014) · Immunological Reviews · doi:10.1111/imr.12171 · Cited by 54 · see citing works

How colonization by microbiota in early life shapes the immune system

Gensollen, T., Iyer, S. S., Kasper, D. L., & Blumberg, R. S. (2016) · Science · doi:10.1126/science.aad9378 · Cited by 2,044 · see citing works

The microbiota in adaptive immune homeostasis and disease

Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · see citing works

Dysbiosis and the immune system

Levy, M., Kolodziejczyk, A. A., Thaiss, C. A., & Elinav, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.7 · Cited by 1,769 · see citing works

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Zhang, L., Yu, X., Zheng, L., Zhang, Y., Li, Y., Fang, Q., Gao, R., Kang, B., Zhang, Q., Huang, J. Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0694-x · Cited by 1,505 · see citing works

Pathophysiology of Inflammatory Bowel Diseases

Chang, J. T. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2002697 · Cited by 1,295 · see citing works

Homeostatic Immunity and the Microbiota

Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., et al. (2019) · Nature · doi:10.1038/s41586-019-0878-z · Cited by 1,145 · see citing works

Regulatory T Cells and Human Disease

Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,132 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,060 · see citing works

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Song, X., Sun, X., Oh, S. F., Wu, M., Zhang, Y., Zheng, W., Geva-Zatorsky, N., Jupp, R., Mathis, D., Benoist, C., et al. (2020) · Nature · doi:10.1038/s41586-019-1865-0 · Cited by 1,024 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

The gut microbiome: Relationships with disease and opportunities for therapy

Durack, J., & Lynch, S. V. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180448 · Cited by 955 · see citing works

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Campbell, C., McKenney, P. T., Konstantinovsky, D., Isaeva, O. I., Schizas, M., Verter, J., Mai, C., Jin, W.-B., Guo, C.-J., Violante, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2193-0 · Cited by 901 · see citing works

Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cai, J., Sun, L., & Gonzalez, F. J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.02.004 · Cited by 869 · see citing works

Host–microbiota interactions in inflammatory bowel disease

Caruso, R., Lo, B. C., & Núñez, G. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0268-7 · Cited by 776 · see citing works

Mining the Human Gut Microbiota for Immunomodulatory Organisms

Geva-Zatorsky, N., Sefik, E., Kua, L., Pasman, L., Tan, T. G., Ortiz-Lopez, A., Yanortsang, T. B., Yang, L., Jupp, R., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.022 · Cited by 762 · see citing works

Treg cell-based therapies: challenges and perspectives

Raffin, C., Vo, L. T., & Bluestone, J. A. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0232-6 · Cited by 728 · see citing works

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726 · see citing works

Regulatory T cells in autoimmune disease

Dominguez-Villar, M., & Hafler, D. A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0120-4 · Cited by 713 · see citing works

A weaning reaction to microbiota is required for resistance to immunopathologies in the adult

Al Nabhani, Z., Dulauroy, S., Marques, R., Cousu, C., Al Bounny, S., Déjardin, F., Sparwasser, T., Bérard, M., Cerf-Bensussan, N., & Eberl, G. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.014 · Cited by 679 · see citing works

Cytokine Regulation and Function in T Cells

Dong, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053702 · Cited by 594 · see citing works

Development and maintenance of intestinal regulatory T cells

Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553 · see citing works

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549 · see citing works

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

Kim, K. S., Hong, S., Han, D., Yi, J., Jung, J., Yang, B., Lee, J. Y., Lee, M., & Surh, C. D. (2016) · Science · doi:10.1126/science.aac5560 · Cited by 541 · see citing works

Tissue Tregs

Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Miragaia, R. J., Gomes, T., Chomka, A., Jardine, L., Riedel, A., Hegazy, A. N., Whibley, N., Tucci, A., Chen, X., Lindeman, I., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.001 · Cited by 499 · see citing works

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R. (2018) · Nature · doi:10.1038/nature25500 · Cited by 498 · see citing works

Helper T cell differentiation

Saravia, J., Chapman, N. M., & Chi, H. (2019) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-019-0220-6 · Cited by 489 · see citing works

Principles of regulatory T cell function

Dikiy, S., & Rudensky, A. Y. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.004 · Cited by 450 · see citing works

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H.-J. J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617460113 · Cited by 427 · see citing works

CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm

Hirahara, K., & Nakayama, T. (2016) · International Immunology · doi:10.1093/intimm/dxw006 · Cited by 417 · see citing works

The cis-Regulatory Atlas of the Mouse Immune System

Yoshida, H., Lareau, C. A., Ramírez, R. N., Rose, S. A., Maier, B. B., Wroblewska, A., Desland, F. A., Chudnovskiy, A., Mortha, A., Dominguez, C. X., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.036 · Cited by 375 · see citing works

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

Gonçalves, P., Araújo, J. R., & Santo, J. P. D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx029 · Cited by 396 · see citing works

Stability and function of regulatory T cells expressing the transcription factor T-bet

Levine, A. G., Mendoza, A., Hemmers, S., Moltedo, B., Niec, R. E., Schizas, M., Hoyos, B. E., Putintseva, E. V., Chaudhry, A., Dikiy, S., et al. (2017) · Nature · doi:10.1038/nature22360 · Cited by 394 · see citing works

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

Abdel-Gadir, A., Victor, E. S., Gerber, G. K., Rivas, M. N., Wang, S., Harb, H., Wang, L., Li, N., Crestani, E., Spielman, S. C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0461-z · Cited by 392 · see citing works

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Zemmour, D., Zilionis, R., Kiner, E., Klein, A. M., Mathis, D., & Benoist, C. (2018) · Nature Immunology · doi:10.1038/s41590-018-0051-0 · Cited by 384 · see citing works

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Zhu, X., & Zhu, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218011 · Cited by 380 · see citing works

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases

Ohkura, N., & Sakaguchi, S. (2020) · Cell Research · doi:10.1038/s41422-020-0324-7 · Cited by 356 · see citing works

T Helper Cell Differentiation, Heterogeneity, and PlasticityPreprint

Zhu, J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030338 · Cited by 352 · see citing works

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment

Guo, X. Y., Liu, X. J., & Hao, J. Y. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12849 · Cited by 340 · see citing works

Regulatory T Cell Development

Savage, P. A., Klawon, D. E. J., & Miller, C. H. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100219-020937 · Cited by 321 · see citing works

IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote T H 17-dependent inflammation

Viladomiu, M., Kivolowitz, C., Abdulhamid, A., Dogan, B., Victorio, D., Castellanos, J. G., Woo, V., Teng, F., Tran, N. L., Sczesnak, A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9655 · Cited by 314 · see citing works

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships

Plichta, D. R., Graham, D. B., Subramanian, S., & Xavier, R. J. (2019) · Cell · doi:10.1016/j.cell.2019.07.045 · Cited by 314 · see citing works

Pathogenesis of ankylosing spondylitis — recent advances and future directions

Ranganathan, V., Gracey, E., Brown, M. A., Inman, R. D., & Haroon, N. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.56 · Cited by 313 · see citing works

Mining the microbiota for microbial and metabolite-based immunotherapies

Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

Li, W., Hang, S., Fang, Y., Bae, S., Zhang, Y., Zhang, M., Wang, G., McCurry, M. D., Bae, M., Paik, D., et al. (2021) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2021.07.013 · Cited by 306 · see citing works

Gut-Lung Axis: The Microbial Contributions and Clinical Implications

He, Y., Wen, Q., Yao, F., Xu, D., Huang, Y., & Wang, J. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1176988 · Cited by 301 · see citing works

Imprinting of the immune system by the microbiota early in life

Al Nabhani, Z., & Eberl, G. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0257-y · Cited by 301 · see citing works

Control of Immunity by the Microbiota

Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 299 · see citing works

Commensal Microbiota Modulation of Natural Resistance to Virus Infection

Stefan, K. L., Kim, M. V., Iwasaki, A., & Kasper, D. L. (2020) · Cell · doi:10.1016/j.cell.2020.10.047 · Cited by 290 · see citing works

ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J. L. C., et al. (2022) · Nature · doi:10.1038/s41586-022-05141-x · Cited by 295 · see citing works

TH17 cell heterogeneity and its role in tissue inflammation

Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works

The Commensal Microbiota and Viral Infection: A Comprehensive Review

Li, N., Ma, W., Pang, M., Fan, Q., & Hua, J.-L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01551 · Cited by 282 · see citing works

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

Delacher, M., Imbusch, C. D., Weichenhan, D., Breiling, A., Hotz-Wagenblatt, A., Träger, U., Hofer, A.-C., Kägebein, D., Wang, Q., Frauhammer, F., et al. (2017) · Nature Immunology · doi:10.1038/ni.3799 · Cited by 282 · see citing works

Tissue regulatory T cells: regulatory chameleons

Muñoz-Rojas, A. R., & Mathis, D. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00519-w · Cited by 281 · see citing works

Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota

Akagbosu, B., Tayyebi, Z., Shibu, G., Paucar Iza, Y. A., Deep, D., Parisotto, Y. F., Fisher, L., Pasolli, H. A., Thevin, V., Elmentaite, R., et al. (2022) · Nature · doi:10.1038/s41586-022-05309-5 · Cited by 273 · see citing works

Accounting for reciprocal host–microbiome interactions in experimental science

Stappenbeck, T. S., & Virgin, H. W. (2016) · Nature · doi:10.1038/nature18285 · Cited by 270 · see citing works

Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria

Knoop, K. A., Gustafsson, J. K., McDonald, K. G., Kulkarni, D. H., Coughlin, P. E., McCrate, S., Kim, D., Hsieh, C., Hogan, S. P., Elson, C. O., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aao1314 · Cited by 261 · see citing works

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.018 · Cited by 268 · see citing works

TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Liu, Y., Yang, M., Tang, L., Wang, F., Huang, S., Liu, S., Lei, Y., Wang, S., Xie, Z., Wang, W., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01296-x · Cited by 270 · see citing works

Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer

Bultman, S. J. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500902 · Cited by 269 · see citing works

Th17 plasticity and its relevance to inflammatory bowel disease

Ueno, A., Jeffery, L. E., Kobayashi, T., Hibi∥, T., Ghosh, S. K., & Jijon, H. B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.004 · Cited by 263 · see citing works

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05089-y · Cited by 261 · see citing works

The Microgenderome Revealed: Sex Differences in Bidirectional Interactions between the Microbiota, Hormones, Immunity and Disease Susceptibility

Vemuri, R., Sylvia, K. E., Klein, S. L., Forster, S. C., Plebanski, M., Eri, R., & Flanagan, K. L. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-018-0716-7 · Cited by 265 · see citing works

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works

Mechanisms of Oral Tolerance

Tordesillas, L., & Berin, M. C. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8680-5 · Cited by 262 · see citing works

Antibiotics in early life: dysbiosis and the damage done

Neuman, H., Forsythe, P., Uzan-Yulzari, A., Avni, O., & Koren, O. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy018 · Cited by 258 · see citing works

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 251 · see citing works

Tissue adaptation of regulatory and intraepithelial CD4 ⁺ T cells controls gut inflammation

Sujino, T., London, M., Hoytema van Konijnenburg, D. P., Rendon, T., Buch, T., Silva, H. M., Lafaille, J. J., Reis, B. S., & Mucida, D. (2016) · Science · doi:10.1126/science.aaf3892 · Cited by 250 · see citing works

CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease

Gómez-Bris, R., Saéz, Á., Herrero‐Fernández, B., Rius, C., Sánchez-Martinez, H., & González, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032696 · Cited by 255 · see citing works

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 256 · see citing works

Tunable Expression Tools Enable Single-Cell Strain Distinction in the Gut Microbiome

Whitaker, W. R., Shepherd, E. S., & Sonnenburg, J. L. (2017) · Cell · doi:10.1016/j.cell.2017.03.041 · Cited by 244 · see citing works

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers

Fidelle, M., Rauber, C., Alves Costa Silva, C., Tian, A.-L., Lahmar, I., de La Varende, A.-L. M., Zhao, L., Thelemaque, C., Lebhar, I., Messaoudene, M., et al. (2023) · Science · doi:10.1126/science.abo2296 · Cited by 243 · see citing works

An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk

Yissachar, N., Zhou, Y., Ung, L., Lai, N. Y., Mohan, J. F., Ehrlicher, A., Weitz, D. A., Kasper, D. L., Chiu, I. M., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.009 · Cited by 242 · see citing works

Cell surface polysaccharides of <i>Bifidobacterium bifidum</i> induce the generation of Foxp3 ⁺ regulatory T cells

Verma, R., Lee, C., Jeun, E.-J., Yi, J., Kim, K. S., Ghosh, A., Byun, S., Lee, C.-G., Kang, H.-J., Kim, G.-C., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat6975 · Cited by 242 · see citing works

Regulatory T Cells: the Many Faces of Foxp3

Georgiev, P., Charbonnier, L., & Chatila, T. A. (2019) · Journal of Clinical Immunology · doi:10.1007/s10875-019-00684-7 · Cited by 242 · see citing works

Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa

Pandiyan, P., Bhaskaran, N., Zou, M., Schneider, E., Jayaraman, S., & Huehn, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00426 · Cited by 231 · see citing works

The microbiome and autoimmunity: a paradigm from the gut–liver axis

Li, B., Selmi, C. F., Tang, R., Gershwin, M. E., & Ma, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.7 · Cited by 234 · see citing works

Immunization with a heat-killed preparation of the environmental bacterium <i>Mycobacterium vaccae</i> promotes stress resilience in mice

Reber, S. O., Siebler, P. H., Donner, N. C., Morton, J. T., Smith, D. G., Kopelman, J. M., Lowe, K. R., Wheeler, K. J., Fox, J. H., Hassell, J. E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600324113 · Cited by 233 · see citing works

The microbiota-immune axis as a central mediator of gut-brain communication

Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 228 · see citing works

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms

Rose, D. R., Yang, H., Serena, G., Sturgeon, C., Ma, B., Careaga, M., Hughes, H. K., Angkustsiri, K., Rose, M., Hertz-Picciotto, I., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.03.025 · Cited by 227 · see citing works

Modulation of T cells by tryptophan metabolites in the kynurenine pathway

Stone, T. W., & Williams, R. O. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.04.006 · Cited by 229 · see citing works

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

Konkel, J. E., Zhang, D., Zanvit, P., Chia, C., Zangerle-Murray, T., Jin, W., Wang, S., & Chen, W. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.015 · Cited by 221 · see citing works

Treg cells in autoimmunity: from identification to Treg-based therapies

Göschl, L., Scheinecker, C., & Bonelli, M. M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00741-8 · Cited by 218 · see citing works

Treg cells in health and autoimmune diseases: New insights from single cell analysis

Scheinecker, C., Göschl, L., & Bonelli, M. M. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102376 · Cited by 218 · see citing works

The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study

Hemmings, S. M. J., Malan-Müller, S., van den Heuvel, L. L., Demmitt, B. A., Stanislawski, M. A., Smith, D. G., Bohr, A. D., Stamper, C. E., Hyde, E. R., Morton, J. T., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000512 · Cited by 208 · see citing works

IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy

Kanagaratham, C., Ansari, Y. S. E., Lewis, O. L., & Oettgen, H. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.603050 · Cited by 208 · see citing works

The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases

Sumida, T. S., Cheru, N. T., & Hafler, D. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00994-x · Cited by 208 · see citing works

The role of the gut microbiota in multiple sclerosis

Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works

Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity

Shi, H., & Chi, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02716 · Cited by 204 · see citing works

Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses

Kim, M., Galan, C., Hill, A. A., Wu, W.-J., Fehlner-Peach, H., Song, H. W., Schady, D., Bettini, M. L., Simpson, K. W., Longman, R. S., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.009 · Cited by 202 · see citing works

Holobionts as Units of Selection and a Model of Their Population Dynamics and Evolution

Roughgarden, J. E., Gilbert, S. F., ROSENBERG, E. B., Zilber‐Rosenberg, I., & Lloyd, E. A. (2017) · Biological Theory · doi:10.1007/s13752-017-0287-1 · Cited by 198 · see citing works

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

Bauché, D., Joyce-Shaikh, B., Jain, R., Grein, J., Ku, K. S., Blumenschein, W. M., Ganal-Vonarburg, S. C., Wilson, D. C., McClanahan, T. K., Malefyt, R. D. W., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.007 · Cited by 202 · see citing works

Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases

Cohen, L. J., Cho, J. H., Gevers, D., & Chu, H. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.017 · Cited by 201 · see citing works

Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

Liu, S., Rezende, R. M., Moreira, T. G., Tankou, S. K., Cox, L. M., Wu, M., Song, A., Dhang, F. H., Wei, Z., Costamagna, G., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.10.008 · Cited by 196 · see citing works

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Jarret, A. P., Jackson, R. P., Duizer, C., Healy, M. E., Zhao, J., Rone, J. M., Bielecki, P., Sefik, E., Roulis, M., Rice, T., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.016 · Cited by 204 · see citing works

Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs

Bradley, C. P., Teng, F., Felix, K. M., Sano, T., Naskar, D., Block, K. E., Huang, H., Knox, K. S., Littman, D. R., & Wu, H.-J. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.007 · Cited by 197 · see citing works

Gut Microbial Alterations Associated With Protection From Autoimmune Uveitis

Nakamura, Y., Metea, C., Karstens, L., Asquith, M. J., Gruner, H., Moscibrocki, C., Lee, I., Brislawn, C., Jansson, J. K., Rosenbaum, J. T., et al. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19733 · Cited by 194 · see citing works

Thymus-derived Foxp3+ regulatory T cells upregulate RORγt expression under inflammatory conditions

Yang, J., Zou, M., Pezoldt, J., Zhou, X., & Huehn, J. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1706-x · Cited by 20 · see citing works

Individual Microbes Shape Various Parts of the Immune System

Sefik, E. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

RORγt Promotes Foxp3 Expression by Antagonizing the Effector Program in Colonic Regulatory T Cells

Bhaumik, S., Mickael, M., Moran, M., Spell, M. L., & Basu, R. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100175 · Cited by 44 · see citing works

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

Yang, B.-H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette, M., Föhse, L., Prinz, I., Pezoldt, J., Suerbaum, S., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.74 · Cited by 435 · see citing works

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05089-y · Cited by 261 · see citing works