The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Induction and Suppression of Collagen-Induced Arthritis Is Dependent on Distinct Fcγ Receptors
Open accessAbstract
Receptors for immunoglobulin (Ig)G (FcγRs) are important for the antibody-mediated effector functions of the immune system. FcγRI and FcγRIII trigger cell activation through a common γ chain, whereas FcγRII acts as a negative regulator of antibody production and immune complex–triggered activation. Here we describe the in vivo consequences of FcγR deficiency in a mouse model of human rheumatoid arthritis. FcRγ chain–deficient mice on arthritis-susceptible DBA/1 background were immunized with collagen for induction of collagen-induced arthritis. The DBA/1 mice lacking FcRγ chain were protected from collagen-induced arthritis in contrast to wild-type mice, although both groups produced similar levels of IgG anticollagen antibodies. In comparison, DBA/1 mice lacking FcγRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcγRI and FcγRIII in triggering autoimmune arthritis.
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Cited by
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Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis
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Self-citation
Metadata
- Authors
- Kleinau, S., Martinsson, P., & Heyman, B.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-05-01
- Volume
- 191
- Issue
- 9
- Pages
- 1611-1616
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2105237436
- Cited by
- 255
- References
- 24
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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