The DOI matches its Crossref record; 264 of the 264 references it cites were found in a registry or an index.
Mouse and human FcR effector functions
Abstract
Summary: Mouse and human FcRs have been a major focus of attention not only of the scientific community, through the cloning and characterization of novel receptors, and of the medical community, through the identification of polymorphisms and linkage to disease but also of the pharmaceutical community, through the identification of FcRs as targets for therapy or engineering of Fc domains for the generation of enhanced therapeutic antibodies. The availability of knockout mouse lines for every single mouse FcR, of multiple or cell‐specific—‘à la carte’—FcR knockouts and the increasing generation of hFcR transgenics enable powerful in vivo approaches for the study of mouse and human FcR biology. This review will present the landscape of the current FcR family, their effector functions and the in vivo models at hand to study them. These in vivo models were recently instrumental in re‐defining the properties and effector functions of FcRs that had been overlooked or discarded from previous analyses. A particular focus will be made on the (mis)concepts on the role of high‐affinity IgG receptors in vivo and on results from antibody engineering to enhance or abrogate antibody effector functions mediated by FcRs.
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Citations
Cites
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Cited by
Wang, S., Mustafa, M., Yuede, C. M., Salazar, S. V., Kong, P., Long, H., Ward, M., Siddiqui, O., Paul, R., Gilfillan, S., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200785 · Cited by 549
SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy
Veillette, A., & Chen, J. (2018) · Trends in Immunology · doi:10.1016/j.it.2017.12.005 · Cited by 476
ImmGen report: sexual dimorphism in the immune system transcriptome
Gal-Oz, S. T., Maier, B., Yoshida, H., Seddu, K., Elbaz, N., Czysz, C., Zuk, O., Stranger, B. E., Ner-Gaon, H., & Shay, T. (2019) · Nature Communications · doi:10.1038/s41467-019-12348-6 · Cited by 274
Tumor-associated neutrophils and neutrophil-targeted cancer therapies
Que, H., Fu, Q., Lan, T., Tian, X., & Wei, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188762 · Cited by 312
Human IgE-independent systemic anaphylaxis
Finkelman, F. D., Khodoun, M. V., & Strait, R. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.015 · Cited by 299
Metadata
- Authors
- Bruhns, P., & Jönsson, F.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-10-26
- Volume
- 268
- Issue
- 1
- Pages
- 25-51
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1862569453
- Cited by
- 579
- References
- 264
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bruhns, P., & Jönsson, F. (2015). Mouse and human FcR effector functions. Immunological Reviews. https://doi.org/10.1111/imr.12350
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
