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The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells
Open accessAbstract
Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node. Cells secreting IgA antibody in response to rotavirus, an intestinal pathogen, also respond well. In contrast, IgG– and IgM–ASC respond poorly. Epithelial cells in the small intestines, a principal site of IgA–ASC localization and IgA production in the body, highly and selectively express TECK. The migration of IgA–ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response.
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Citations
Cited by
NALT- versus PEYER'S-patch-mediated mucosal immunity
Kiyono, H., & Fukuyama, S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1439 · Cited by 745
Moor, A. E., Harnik, Y., Ben-Moshe, S., Massasa, E. E., Rozenberg, M., Eilam, R., Bahar Halpern, K., & Itzkovitz, S. (2018) · Cell · doi:10.1016/j.cell.2018.08.063 · Cited by 480
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394
Chemokines in the systemic organization of immunity
Campbell, D. J., Kim, C. H., & Butcher, E. C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00067.x · Cited by 330
Self-citationLymphocyte homing to the gut: attraction, adhesion, and commitment
Salmi, M., & Jalkanen, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00285.x · Cited by 103
Metadata
- Authors
- Bowman, E. P., Kuklin, N. A., Youngman, K. R., Lazarus, N. H., Kunkel, E. J., Pan, J., Greenberg, H. B., & Butcher, E. C.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-01-21
- Volume
- 195
- Issue
- 2
- Pages
- 269-275
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2111097182
- Cited by
- 244
- References
- 0
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells. https://app.cochat.ai/papers/10.1084/jem.20010670
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- Bowman, E. P., Kuklin, N. A., Youngman, K. R., Lazarus, N. H., Kunkel, E. J., Pan, J., Greenberg, H. B., & Butcher, E. C. (2002). The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20010670
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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