The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
Open accessAbstract
Peripheral immune tolerance is believed to be induced by the processing and presentation of self-tissues that die during physiologic tissue turnover. To examine the mechanism that mediates tolerance, we injected mice with dying syngeneic TAP−/− splenocytes loaded with small amounts of the protein antigen, ovalbumin (OVA). After ingestion and presentation of cell-associated OVA by the CD8+ subset of dendritic cells in situ, large numbers of antigen-reactive, CD8+ T cell receptor (TCR) transgenic T lymphocytes were driven into cell cycle, but then the T cells were deleted. The animals were also tolerant to challenge with OVA in complete Freund's adjuvant. An agonistic anti-CD40 monoclonal antibody was then administered together with the OVA-loaded splenocytes, so that the dendritic cells in the recipient mice would mature. In contrast to observations made in the steady state, the antigen-reactive T cells expanded in numbers for 1–2 wk and produced large amounts of interleukin 2 and interferon γ, while the animals retained responsiveness to antigen rechallenge. The specific tolerance that develops when dendritic cells process self tissues in the steady state should prevent or reduce the development of autoimmunity when dying cells are subsequently processed during infection.
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Cites
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Self-citationMerad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Molecular mechanism and function of CD40/CD40L engagement in the immune system
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Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512
Metadata
- Authors
- Liu, K., Iyoda, T., Saternus, M., Kimura, Y., Inaba, K., & Steinman, R. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-10-14
- Volume
- 196
- Issue
- 8
- Pages
- 1091-1097
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2116372484
- Cited by
- 468
- References
- 30
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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