The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells
Open accessAbstract
T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands that activate TCR-γδ cells. In tumor cells, blockade of hydroxy-methylglutaryl-CoA reductase (HMGR), the rate limiting enzyme of the mevalonate pathway, prevents both accumulation of mevalonate metabolites and recognition by TCR-γδ cells. When metabolite accumulation is induced by overexpressing HMGR or by treatment with nitrogen-containing bisphosphonate drugs, tumor cells derived from many tissues acquire the capacity to stimulate the same TCR-γδ population. Accumulation of mevalonate metabolites in tumor cells is a powerful danger signal that activates the immune response and may represent a novel target of tumor immunotherapy.
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Cites
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Structural mechanism for statin inhibition of HMG-CoA reductase
Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644
Cited by
Six-of-the-best: unique contributions of γδ T cells to immunology
Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
Mevalonate pathway: A review of clinical and therapeutical implications
Buhaescu, I., & Izzedine, H. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.03.016 · Cited by 620
Silva-Santos, B., Serre, K., & Norell, H. (2015) · Nature reviews. Immunology · doi:10.1038/nri3904 · Cited by 565
Sandstrom, A., Peigné, C.-M., Léger, A., Crooks, J. E., Konczak, F., Gesnel, M.-C., Breathnach, R., Bonneville, M., Scotet, E., & Adams, E. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.003 · Cited by 477
Metadata
- Authors
- Gober, H.-J., Kistowska, M., Angman, L., Jenö, P., Mori, L., & De Libero, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-01-13
- Volume
- 197
- Issue
- 2
- Pages
- 163-168
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2170263258
- Cited by
- 847
- References
- 2
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Gober, H.-J., Kistowska, M., Angman, L., Jenö, P., Mori, L., & De Libero, G. (2003). Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20021500
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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