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Cited by 477

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

Open access
Sandstrom, Andrew, Peigné, Cassie-Marie, Léger, Alexandra, Crooks, James E., Konczak, Fabienne, Gesnel, Marie-Claude, Breathnach, Richard, Bonneville, Marc, Scotet, Emmanuel, Adams, Erin J.·2014·Immunity
DOI 10.1016/j.immuni.2014.03.003
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Abstract

Summary In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections including Mycobacterium tuberculosis through recognition of small pyrophosphate containing organic molecules known as phosphoantigens (pAgs). Key to pAg-mediated activation of Vγ9Vδ2 T cells is the butyrophilin 3A1 (BTN3A1) protein that contains an intracellular B30.2 domain critical to pAg reactivity. Here, we have demonstrated through structural, biophysical and functional approaches that the intracellular B30.2 domain of BTN3A1 directly binds pAg through a positively-charged surface pocket. Charge-reversal of pocket residues abrogates binding and Vγ9Vδ2 T cell activation. We have also identified a gain-of-function mutation within this pocket that when introduced into B30.2 domain of the non-stimulatory BTN3A3 isoform, transfers pAg binding ability and Vγ9Vδ2 T cell activation. These studies demonstrate that internal sensing of changes in pAg metabolite concentrations by BTN3A1 molecules is a critical step in Vγ9Vδ2 T cell detection of infection and tumorigenesis.

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Metadata

Authors
Sandstrom, A., Peigné, C.-M., Léger, A., Crooks, J. E., Konczak, F., Gesnel, M.-C., Breathnach, R., Bonneville, M., Scotet, E., & Adams, E. J.
Venue
Immunity
Publisher
Elsevier BV
Published
2014-04
Volume
40
Issue
4
Pages
490-500
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2014.03.003
OpenAlex
W1992794673
Cited by
477
References
39
FWCI
17.12
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells. https://app.cochat.ai/papers/10.1016/j.immuni.2014.03.003
The paper
Sandstrom, A., Peigné, C.-M., Léger, A., Crooks, J. E., Konczak, F., Gesnel, M.-C., Breathnach, R., Bonneville, M., Scotet, E., & Adams, E. J. (2014). The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells. Immunity. https://doi.org/10.1016/j.immuni.2014.03.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.