Cited by 642Monoclonal and Polyclonal Antibodies ResearchProtein Interaction Studies and Fluorescence AnalysisBiomarkers in Disease Mechanisms

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The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

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Chaudhury, Chaity, Mehnaz, Samina, Robinson, John M., Hayton, William L., Pearl, Dennis K., Roopenian, Derry C., Anderson, Clark L.·2003·The Journal of Experimental Medicine

DOI 10.1084/jem.20021829PMC PMC2193842

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Abstract

The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex–related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.

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Authors: Chaudhury, C., Mehnaz, S., Robinson, J. M., Hayton, W. L., Pearl, D. K., Roopenian, D. C., & Anderson, C. L.
Affiliations: The Ohio State University (US)
Jackson Laboratory (US)
ORCID: Mehnaz, Samina
Robinson, John M.
Pearl, Dennis K.
Roopenian, Derry C.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2003-01-27
Volume: 197
Issue: 3
Pages: 315-322
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.20021829
PMC: PMC2193842
OpenAlex: W2127401827
Cited by: 640
References: 37
Citations by year: 2026: 27 · 2025: 39 · 2024: 35 · 2023: 29 · 2022: 40 · 2021: 50 · 2020: 33 · 2019: 34 · 2018: 41 · 2017: 28 · 2016: 31 · 2015: 29 · 2014: 35 · 2013: 29 · 2012: 30
FWCI: 8.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: Lupus Research Alliance
National Institutes of Health
National Cancer Institute (CA88053, R01CA088053)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-56597, R01DK056597)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD038764, HD-38764)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords: neonatal Fc receptor, albumin, pH-dependent binding, plasma protein turnover, IgG half-life
MeSH terms: Animals, Cattle, Half-Life, Cricetinae, Hydrogen-Ion Concentration, Immunoglobulin G, Major Histocompatibility Complex, Mice, Inbred C57BL, Protein Binding, Receptors, Fc, Recombinant Proteins, Serum Albumin, Bovine, Histocompatibility Antigens Class I, CHO Cells, Mice, Knockout, Mice, Rats, In Vitro Techniques

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The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

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