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Cited by 256

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

Open access
Salek-Ardakani, Shahram, Song, Jianxun, Halteman, Beth S., Jember, Amha Gebre-Hiwot, Akiba, Hisaya, Yagita, Hideo, Croft, Michael·2003·The Journal of Experimental Medicine
DOI 10.1084/jem.20021937
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Abstract

Asthma is caused by memory Th2 cells that often arise early in life and persist after repeated encounters with allergen. Although much is known regarding how Th2 cells develop, there is little information about the molecules that regulate memory Th2 cells after they have formed. Here we show that the costimulatory molecule OX40 is expressed on memory CD4 cells. In already sensitized animals, blocking OX40–OX40L interactions at the time of inhalation of aerosolized antigen suppressed memory effector accumulation in lung draining lymph nodes and lung, and prevented eosinophilia, airway hyperreactivity, mucus secretion, and Th2 cyto-kine production. Demonstrating that OX40 signals directly regulate memory T cells, antigen-experienced OX40-deficient T cells were found to divide initially but could not survive and accumulate in large numbers after antigen rechallenge. Thus, OX40–OX40L interactions are pivotal to the efficiency of recall responses regulated by memory Th2 cells.

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Metadata

Authors
Salek-Ardakani, S., Song, J., Halteman, B. S., Jember, A. G.-H., Akiba, H., Yagita, H., & Croft, M.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2003-07-14
Volume
198
Issue
2
Pages
315-324
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20021937
OpenAlex
W2135516248
Cited by
256
References
33
FWCI
10.31
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation. https://app.cochat.ai/papers/10.1084/jem.20021937
The paper
Salek-Ardakani, S., Song, J., Halteman, B. S., Jember, A. G.-H., Akiba, H., Yagita, H., & Croft, M. (2003). OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20021937

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.