The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
Abstract
Summary: The members of the tumour necrosis factor (TNF)/tumour necrosis factor receptor (TNFR) superfamily are critically involved in the maintenance of homeostasis of the immune system. The biological functions of this system encompass beneficial and protective effects in inflammation and host defence as well as a crucial role in organogenesis. At the same time, members of this superfamily are responsible for host damaging effects in sepsis, cachexia, and autoimmune diseases. This review summarizes recent progress in the immunbiology of the TNF/TNFR superfamily focusing on results obtained from animal studies using gene targeted mice. The different modes of signalling pathways affecting cell proliferation, survival, differentiation, apoptosis, and immune organ development as well as host defence are reviewed. Molecular and cellular mechanisms that demonstrate a therapeutic potential by targeting individual receptors or ligands for the treatment of chronic inflammatory or autoimmune diseases are discussed.
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Cites
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Cited by
Tumour necrosis factor and cancer
Balkwill, F. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2628 · Cited by 1,915
TNF-α in promotion and progression of cancer
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The proinflammatory cytokine-induced IRG1 protein associates with mitochondria
Degrandi, D., Hoffmann, R., Beuter-Gunia, C., & Pfeffer, K. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0013 · Cited by 155
Self-citationCytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling
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Metadata
- Authors
- Hehlgans, T., & Pfeffer, K.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2005-04-10
- Volume
- 115
- Issue
- 1
- Pages
- 1-20
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2123838494
- Cited by
- 1,048
- References
- 226
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hehlgans, T., & Pfeffer, K. (2005). The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology. https://doi.org/10.1111/j.1365-2567.2005.02143.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
